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Chemical properties Uses Toxicity
Chemical Name:
Benzidin;ai3-00140;Benzidina;Benzydyna;BENZIDINE;Benzioine;NCI-C03361;C.I. 37225;NSC 146476;p-benzidine
Molecular Formula:
Formula Weight:
MOL File:

Benzidine Properties

Melting point:
127-128 °C
Boiling point:
refractive index 
1.6266 (estimate)
Flash point:
11 °C
storage temp. 
4.66(at 30℃)
Water Solubility 
Sparingly soluble. <0.1 g/100 mL at 22 ºC
Stable. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference
92-87-5(CAS DataBase Reference)
NIST Chemistry Reference
EPA Substance Registry System
[1,1'-Biphenyl]- 4,4'-diamine(92-87-5)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T,N,F,Xn
Risk Statements  45-22-50/53-52/53-39/23/24/25-23/24/25-11-36/37/38-20/21/22-51/53-67
Safety Statements  53-45-60-61-36/37-16-7-36-26
RIDADR  UN 1885 6.1/PG 2
WGK Germany  3
RTECS  DC9625000
HazardClass  6.1(a)
PackingGroup  II
Hazardous Substances Data 92-87-5(Hazardous Substances Data)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H350 May cause cancer Carcinogenicity Category 1A, 1B Danger
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning P273, P391, P501
H411 Toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 2
Precautionary statements:
P201 Obtain special instructions before use.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P391 Collect spillage. Hazardous to the aquatic environment
P308+P313 IF exposed or concerned: Get medical advice/attention.
P370+P378 In case of fire: Use … for extinction.
P501 Dispose of contents/container to..…

Benzidine price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 12115 Benzidine purum p.a., ≥98.0% (N) 92-87-5 10g $335 2017-11-08 Buy
Sigma-Aldrich 12115 Benzidine purum p.a., ≥98.0% (N) 92-87-5 50g $1275 2017-11-08 Buy
Sigma-Aldrich 12115 Benzidine purum p.a., ≥98.0% (N) 92-87-5 100g $1335 2017-11-08 Buy
Sigma-Aldrich B3503 Benzidine ≥98.0% (N) 92-87-5 10g $479.5 2017-11-08 Buy
Sigma-Aldrich 40005 Benzidine solution 92-87-5 1EA $42 2017-11-08 Buy

Benzidine Chemical Properties,Uses,Production

Chemical properties

It appears as white or light pink crystalline powder with a melting point of 125 ℃, the boiling point of 400 ℃, (98.7kPa) and the relative density of 1.250 (20/4 ℃). It is soluble in boiling ethanol, acetic acid and diluted hydrochloric acid, slightly soluble in ether, slightly soluble in boiling water and slightly soluble in cold water. Its color is darkened under air and light. Analysis reagents are usually benzodine hydrochloride or acetate, which is more soluble, and sulfate is commonly used in the industry. Benzidine acetate is white or nearly white crystals, being soluble in water, acetic acid and hydrochloric acid, as an indicator. Benzidine sulfate is a white crystalline powder or flaky crystal, being soluble in ether, very slightly soluble in water, dilute acid and alcohol.


Important dye intermediates, benzidine and its derivatives can be used to make direct dyes, acid dyes, vat dyes, ice dyed dyes, sulfur dyes, reactive dyes and organic pigments. More than 250 dyes are made from benzidine, of which the most important is the direct black EW. The benzidine yellow is a widely used organic pigment.


Benzidine is highly toxic, can be absorbed through the respiratory tract, skin and digestive tract, and is highly toxic, belonging to a carcinogen. Both solid and vapor are quickly absorbed through the skin, causing blood damage and causing bladder cancer. Mistakenly eating it can cause nausea, vomiting, liver and kidney damage. Mice oral LD50: 214mg / kg (body weight), rat oral LD50: 309 mg / kg (body weight). Rabbits and dogs have an oral minimum lethal dose of 200mg / kg (weight). The major toxic effect is hemorrhagic cystitis. The effect on the formation of methemoglobin is weak. It has stimulation effect on the skin and mucous membranes, being capable of causing contact dermatitis. It can cause liver cancer in mice and hamsters, causing rat liver, Zymbal gland, breast and colon cancer and cause bladder cancer in dogs. A variety of short-term mutagenicity test has given positive results. The International Agency for Research on Cancer (IARC) classifies it as a human carcinogen (well-documented) with the targets being bladder. The relative risk of bladder cancer in dyes chemical worker is 19 with the incubation period of about 19 years.


Benzidine is a white, greyish-yellow, or slightly reddish crystalline solid or powder. The major use for benzidine is in the production of dyes, especially azo dyes in the leather, textile, and paper industries and as a synthetic precursor in the preparation and manufacture of dyestuffs. It is also used in the manufacture of rubber, as a reagent, and as a stain in microscopy. It is slightly soluble and slowly changes from a solid to a gas.

Chemical Properties

Off-White Solid


Potentially mutagenic compound.


ChEBI: A member of the class of biphenyls that is 1,1'-biphenyl in which the hydrogen at the para-position of each phenyl group has been replaced by an amino group.

General Description

A grayish-yellow to grayish-red, crystalline solid. Toxic by ingestion, inhalation, and skin absorption. Combustion produces toxic oxides of nitrogen. Used to make other chemicals and in chemical and biological analysis.

Air & Water Reactions

Darkens on exposure to air and light. Soluble in hot water.

Reactivity Profile

Benzidine forms insoluble salts with sulfuric acid. Can be diazotized, acetylated and alkylated. Is hypergolic with red fuming nitric acid . Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

Poisonous if inhaled, swallowed or absorbed through skin. May cause contact dermatitis, irritation or sensitization. Ingestion may cause nausea and vomiting.

Purification Methods

Its solution in *benzene is decolorized by percolating through two 2-cm columns of activated alumina, then concentrated until benzidine crystallises on cooling. Recrystallise alternately from EtOH and *benzene to constant absorption spectrum [Carlin et al. J Am Chem Soc 73 1002 1951]. It has also been crystallised from hot water (charcoal) and from diethyl ether. Dry it under vacuum in an Abderhalden pistol. Store it in the dark in a stoppered container. CARCINOGENIC. [Beilstein 13 IV 364.]

Benzidine Preparation Products And Raw materials

Raw materials

Preparation Products

Benzidine Suppliers

Global( 143)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32764 55
TianJin Alta Scientific Co., Ltd. +86-022-6537-8550
+86-022-2532-9655 China 2849 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933; China 96815 76
BeiJing Hwrk Chemicals Limted 4006990298;010-57411839;0757-86311057;021-51691807
010-87653215;0757-86311057;021-55236763 China 14687 55
Beijing Ouhe Technology Co., Ltd +86-10-4006331231;+86-10-51280831;+86-10-82967028
+86-10-82967029 China 12613 60
Adamas Reagent, Ltd. 400-600-9262 China 14017 59
Chemfun Medical Technology(Shanghai) Co., Ltd. 021-67220633 & 021-37212706
+86-21-67220638 China 21898 59
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202,021-54308259
+86-21-54291107 China 43423 64
Chemsky(shanghai)International Co.,Ltd. 021-50135380 China 32520 50
Chengdu XiYa Chemical Technology Co., Ltd. 4008-626-111
028-84752058 China 9740 57

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