WHI-P97
- CAS No.
- 211555-05-4
- Chemical Name:
- WHI-P97
- Synonyms
- WHI-P97;WHI-P-97;WHI P97;JAK3 Inhibitor I USP/EP/BP;2,6-dibromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol;Phenol, 2,6-dibromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]-;WHI-P 974-(3',5'-DibroMo-4-hydroxyphenyl)aMino-6,7-diMethoxyquinazoline;Janus kinase,JAK,airway,Inhibitor,WHIP97,eosinophil recruitment,WHI-P97,inhibit,ovalbumin challenge,WHI P97,ovalbumin-sensitized,WHI-P-97
- CBNumber:
- CB52502882
- Molecular Formula:
- C16H13Br2N3O3
- Molecular Weight:
- 455.1
- MDL Number:
- MFCD02683947
- MOL File:
- 211555-05-4.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H317 |
Precautionary statements | P261-P272-P280-P302+P352-P333+P313-P321-P363-P501 |
WHI-P97 price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
ChemScene | CS-0054 | WHI-P97 99.13% | 211555-05-4 | 5mg | $120 | 2021-12-16 | Buy |
ApexBio Technology | A3936 | WHI-P97 | 211555-05-4 | 2mg | $142 | 2021-12-16 | Buy |
ChemScene | CS-0054 | WHI-P97 99.13% | 211555-05-4 | 10mg | $210 | 2021-12-16 | Buy |
ApexBio Technology | A3936 | WHI-P97 | 211555-05-4 | 5mg | $221 | 2021-12-16 | Buy |
ApexBio Technology | A3936 | WHI-P97 | 211555-05-4 | 10mg | $331 | 2021-12-16 | Buy |
WHI-P97 Chemical Properties,Uses,Production
Definition
ChEBI: 2,6-dibromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenol is a member of quinazolines.
Biological Activity
WHI-P97 is a potent JAK-3 inhibitor with Ki of 0.09 μM and IC50 of 2.5 μM in EGFR kinase inhibition assay.
in vitro
WHI-P97 inhibits the translocation of 5-lipoxygenase (5-LO) from the nucleoplasm to the nuclear membrane and consequently 5-LO-dependent leukotriene (LT) synthesis after IgE receptor/FcεRI crosslinking by >90 % at low micromolar concentrations. WHI-P97 (30 μM) stantially reduces the IgE/antigen-induced LTC4 release from mast cells.
in vivo
WHI-P97 is very well tolerated in mice, with no signs of toxicity at dose levels ranging from 5 μg/kg to 50 mg/kg, and LD 10 is not reached at a 50 mg/kg dose level when administered as a single ip or iv bolus dose. WHI-P97 (iv injection; 40 mg/kg; single dose) has an elimination half-life (t 1/2 ) of 58.9 min and systemic clearance (CL) of 891 ml/h/kg in CD-1 mice and at 1/2 of 84.2 min and CL of 1513 ml/h/kg in BALB/ c mice. The values for AUC and C max are 107.3 μM and 296.7 μM, respectively, in CD-1 mice. And the IC 50 values are 58.4 μM and 212.7 μM , respectively, in BALB/c mice. The large volume of distribution are 322 ml/kg in CD-1 mice and 415 ml/kg in BALB/c mice. WHI-P97 (intraperitoneal injection; 40 mg/kg; 24 days) prevents ovalbumin-sensitized mice the development of airway hyper-responsiveness to methacholine in a dose-dependent fashion in mice. WHI-P97 inhibits the eosinophil recruitment to the airwa y lumen after the ovalbumin challenge in a dose-dependent fashion.
Animal Model: | BALB/c mouse model of allergic asthma td> |
Dosage: | 40 mg/kg |
Administration: | intraperitoneal injection; 24 days |
Result: | Showed promising biological activity in a mouse model of allergic asthma at nontoxic dose levels. |
target
Target | Value | ||||
JAK3 () |
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |