JAK3 INHIBITOR I
- CAS No.
- 202475-60-3
- Chemical Name:
- JAK3 INHIBITOR I
- Synonyms
- CS-2623;Janex 1;WHI-P131;WHI-P131, >98%;JAK3 INHIBITOR I;JANEX-1;WHI-P131;WHI-P131(Janex 1);A JAK3 inhibitor WHI-P131;WHIP-131;JANEX-1);WHIP131;JANEX1;4-(6,7-dimethoxyquinazolin-4-ylamino)phenol
- CBNumber:
- CB7130537
- Molecular Formula:
- C16H15N3O3
- Molecular Weight:
- 297.31
- MDL Number:
- MFCD01862614
- MOL File:
- 202475-60-3.mol
- MSDS File:
- SDS
| Boiling point | 468.1±40.0 °C(Predicted) |
|---|---|
| Density | 1.336±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | DMSO: 18 mg/mL, soluble |
| form | solid |
| pka | 10.06±0.26(Predicted) |
| color | yellow |
| Stability | Stable for 2 years from date of purchase as supplied. Protect from moisture. Solutions in DMSO may be stored at -20°C for up to 2 months. |
| FDA UNII | 1J8Q49TR3I |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
JAK3 INHIBITOR I price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 420101 | JAK3 Inhibitor I - CAS 202475-60-3 - Calbiochem | 202475-60-3 | 5MG | $216 | 2024-03-01 | Buy |
| Cayman Chemical | 10011246 | WHI-P131 ≥98% | 202475-60-3 | 1mg | $31 | 2024-03-01 | Buy |
| Cayman Chemical | 10011246 | WHI-P131 ≥98% | 202475-60-3 | 5mg | $133 | 2024-03-01 | Buy |
| Cayman Chemical | 10011246 | WHI-P131 ≥98% | 202475-60-3 | 10mg | $234 | 2024-03-01 | Buy |
| Cayman Chemical | 10011246 | WHI-P131 ≥98% | 202475-60-3 | 25mg | $510 | 2024-03-01 | Buy |
JAK3 INHIBITOR I Chemical Properties,Uses,Production
Description
WHI-P131 (202475-60-3) is a JAK3 inhibitor.?Inhibits human glioblastoma cell adhesion and invasion.1 Increases survival in a mouse ALS model.2 Delays or prevents autoimmune type 1 diabetes in NOD mice.3 Exhibits potent anti-inflammatory activity in mouse models of peritonitis, colitis, cellulitis and systemic inflammatory response syndrome.4 Displays protective effects against myocardial ischemia and reperfusion injury in mouse models.5
Uses
Janex 1 is a Janus tyrosine kinase 3 (JAK3) inhibitor. Inhibition of JAK3 has been shown to exhibit protective action against the development of T1D in non-obese diabetic (NOD) mice. Janex 1 has been shown to suppresses proliferation of short-term cultured NOD CD4+ T cells through induction of apoptosis, while promoting survival of a particular population of long-term cultured cells. It ameliorates the expression of TNF-α-induced cell adhesion molecules and improves myocardial vascular permeability.
References
1) Narla et al. (1998), Inhibition of human glioblastoma cell adhesion and invasion by 4-(4’-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P131) and 4-(3’-bromo-4’-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P154); Mol. Clin. Cancer Res., 4 2463 2) Trieu et al. (2000), A specific inhibitor of janus kinase-3 increases survival in a transgenic mouse model of amyotrophic lateral sclerosis; Biochem. Biophys. Res. Commun., 267 22 3) Cetkovic-Cvrlje et al. (2003), Targeting JAK3 with JANEX-1 for prevention of autoimmune type 1 diabetes in NOD mice; Clin. Immunol., 106 213 4) Uckun et al. (2008), Anti-inflammatory activity profile of JANEX-1 in preclinical animal models; Bioorg. Med. Chem., 16 1287 5) Oh et al. (2013), Inhibition of Janus activated kinase-3 protects against myocardial ischemia and reperfusion injury in mice; Exp. Mol. Med., 45 e23
JAK3 INHIBITOR I Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9991 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Sichuan Biosynce Pharmatech Co., Ltd. | +8619950309693 | diane@biosynce.com | China | 4874 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
View Lastest Price from JAK3 INHIBITOR I manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-09-06 | 4-(4'-HYDROXYPHENYL)AMINO-6,7-DIMETHOXYQUINAZOLINE
202475-60-3
|
US $1.00 / KG | 1KG | 98% | 20kg | Career Henan Chemical Co |
-
- 4-(4'-HYDROXYPHENYL)AMINO-6,7-DIMETHOXYQUINAZOLINE
202475-60-3
- US $1.00 / KG
- 98%
- Career Henan Chemical Co
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