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LY2584702

CAS No.
1082949-67-4
Chemical Name:
LY2584702
Synonyms
CS-1752;LY2584702;LY2584702 BASE;LY2584702 TsOH;LY2584702 USP/EP/BP;LY-2584702 (free base);LY-2584702 free base (LY2584702);4-[4-[4-[4-Fluoro-3-(trifluoromethyl)phenyl]-1-methylimidazol-2-yl]piperidin-1-yl]-1H-pyrazolo;4-[4-[4-[4-Fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl]-1-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidine;1H-Pyrazolo[3,4-d]pyrimidine, 4-[4-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl]-1-piperidinyl]-
CBNumber:
CB52728813
Molecular Formula:
C21H19F4N7
Molecular Weight:
445.42
MDL Number:
MFCD18633220
MOL File:
1082949-67-4.mol
MSDS File:
SDS
Last updated:2023-09-20 16:43:00

LY2584702 Properties

storage temp. RT (des.)
solubility Soluble in DMSO (up to 1 mg/ml) or in DMF (up to 3 mg/ml).
form solid
color Yellow
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months.
FDA UNII I4965C6W4O

SAFETY

Risk and Safety Statements

HS Code  2933998090

LY2584702 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC L486540 LY2584702 1082949-67-4 10mg $155 2021-12-16 Buy
TRC L486540 LY2584702 1082949-67-4 25mg $360 2021-12-16 Buy
Apolloscientific BISN0247 Ly2584702 1082949-67-4 25mg $348 2021-12-16 Buy
American Custom Chemicals Corporation KIN0002488 LY-2584702 95.00% 1082949-67-4 5MG $497.65 2021-12-16 Buy
Biorbyt Ltd orb611834 LY-2584702 free base 1082949-67-4 50mg $584.8 2021-12-16 Buy
Product number Packaging Price Buy
L486540 10mg $155 Buy
L486540 25mg $360 Buy
BISN0247 25mg $348 Buy
KIN0002488 5MG $497.65 Buy
orb611834 50mg $584.8 Buy

LY2584702 Chemical Properties,Uses,Production

Description

LYS6K2 (1082949-67-4) is a selective inhibitor of the p70 ribosomal S6 kinase (S6K).1 Blocks the phosphorylation of S6 at concentrations as low as 0.1-0.3 μM with no activity at GSK3β and Erk1/2 at 10 μM.2?LYS6K2 is a useful tool to dissect insulin receptor signaling pathways and was employed to show that the action of mTORC1 on SREB P-1c expression is not mediated by S6K.2?Cell permeable.

Uses

LY 2584702 is an orally available inhibitor of p70S6K signalling and potential antineoplastic activity. Used in combination with Erlotinib or Everolimus as an anti-tumor treatment.

References

1) Fenton et al. (2011), Functions and regulation of the 70kDa ribosomal S6 kinases; Int. J. Biochem. Cell Biol., 43 47 2) Li et al. (2010), Bifurcation of insulin signaling pathway in the rat liver: mTORC1 required for stimulation of lipogenesis, but no inhibition of gluconeogenesis; Proc. Natl. Acad. Sci. USA 107 3441

LY2584702 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 73)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32836 60
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28180 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250 1026@dideu.com China 23999 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc.
+1-781-999-5354 support@targetmol.com United States 19973 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 57511 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 131980 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2923 55
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7553 61
CEG Chemical Science&Technology Co., Ltd. Mobile:13665161512 China 1785 58

LY2584702 Spectrum

LY2584702 LY-2584702 (free base) LY2584702 TsOH 4-[4-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-imidazol-2-yl]-1-piperidyl]-1H-pyrazolo[3,4-d]pyrimidine LY2584702 4-[4-[4-[4-Fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl]-1-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidine 4-[4-[4-[4-Fluoro-3-(trifluoromethyl)phenyl]-1-methylimidazol-2-yl]piperidin-1-yl]-1H-pyrazolo LY2584702 USP/EP/BP 1H-Pyrazolo[3,4-d]pyrimidine, 4-[4-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl]-1-piperidinyl]- CS-1752 LY-2584702 free base (LY2584702) LY2584702 BASE Ribosomal S6 Kinase (RSK),LY2584702,LY 2584702,S6K,Inhibitor,inhibit,LY2584702 free base,LY 2584702 free base,LY-2584702 1082949-67-4 C21H19F4N7 Inhibitors