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DL-α-Tocopherol

CAS No.
10191-41-0
Chemical Name:
DL-α-Tocopherol
Synonyms
A-TOCOPHEROL;DL-ALPHA-TOCOPHEROL;DL-TOCOPHEROL;RAC-ALPHA-TOCOPHEROL;ALL-RAC-ALPHA-TOCOPHEROL;All-rac-α-Tocopherol;all-rac-α-Tocopherol;DL-ALPHA TOCOPHERYL ACETATE 500;(R)-2,5,7,8-tetraMethyl-2-((4R,8R)-4,8,12-triMethyltridecyl)chroMan-6-ol;3,
CBNumber:
CB5275357
Molecular Formula:
C29H50O2
Molecular Weight:
430.71
MDL Number:
MFCD00072051
MOL File:
10191-41-0.mol
MSDS File:
SDS
Last updated:2024-05-14 16:18:08

DL-α-Tocopherol Properties

Melting point 2-4°C
alpha [α]D20 - 0.02 - +0.02゜ (neat)
Boiling point 200-220°C 0,1mm
Density 0.950 g/mL at 20 °C(lit.)
refractive index n20/D 1.506
Flash point 240°C
storage temp. 2-8°C
solubility H2O: insoluble
form Pale yellow oil
pka 11.40±0.40(Predicted)
color Colourless to Dark Yellow
Odor at 100.00?%. bland
Water Solubility Miscible with chloroform, vegetable oils, ether, acetone and alcohol. Immiscible with water.
Sensitive Light Sensitive
Merck 14,9495
BRN 94012
InChIKey GVJHHUAWPYXKBD-IEOSBIPESA-N
LogP 12.2 at 25℃
CAS DataBase Reference 10191-41-0(CAS DataBase Reference)
FDA UNII 7QWA1RIO01
EPA Substance Registry System 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)- (10191-41-0)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H317
Precautionary statements  P261-P272-P280-P333+P313-P362+P364-P501
Hazard Codes  Xi,T,F
Risk Statements  36/37/38-39/23/24/25-23/24/25-11
Safety Statements  26-37/39-45-36/37-16-7
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  1
RTECS  GA8746000
8-10-23
TSCA  Yes
HS Code  29362800
NFPA 704
1
2 1

DL-α-Tocopherol price More Price(50)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich V-020 (±)−α−Tocopherol (Vitamin E) solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? 10191-41-0 1mL $74.9 2024-03-01 Buy
Sigma-Aldrich 90669 (±)-α-Tocopherol testedaccordingtoPh.Eur. 10191-41-0 50g $150 2024-03-01 Buy
Sigma-Aldrich 613420 DL-α-Tocopherol - CAS 10191-41-0 - Calbiochem A physiological membrane-bound antioxidant that protects cell membrane lipids from oxidative damage by free radicals. 10191-41-0 50G $81.5 2024-03-01 Buy
Sigma-Aldrich 5.00949 all-rac-α-Tocopherol EMPROVE? ESSENTIAL Ph Eur,BP,USP,E 307 10191-41-0 5kg $1389 2024-03-01 Buy
Sigma-Aldrich 5.00949 all-rac-α-Tocopherol EMPROVE? ESSENTIAL Ph Eur,BP,USP,E 307 10191-41-0 20kg $5101 2024-03-01 Buy
Product number Packaging Price Buy
V-020 1mL $74.9 Buy
90669 50g $150 Buy
613420 50G $81.5 Buy
5.00949 5kg $1389 Buy
5.00949 20kg $5101 Buy

DL-α-Tocopherol Chemical Properties,Uses,Production

Chemical Properties

Alpha tocopherol is a natural product. The PhEur 6.0 describes alpha-tocopherol as a clear, colorless or yellowish-brown, viscous, oily liquid.

Chemical Properties

1mg = 1.1 IU

Uses

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Uses

dl-α-Tocopherol is the racemic analog of α-Tocopherol (T526125), the most bioactive of the naturally occurring forms of Vitamin E. Richest sources are green vegetables, grains, and oils, particularly palm, safflower and sunflower oils. dl-α-Tocopherol is an antioxidant that protects cell membrane lipids from oxidative damage.

Uses

DL-α-Tocopherol is used as an antioxidant that protects cell membrane lipids from oxidative damage.

Production Methods

Naturally occurring tocopherols are obtained by the extraction or molecular distillation of steam distillates of vegetable oils; for example, alpha tocopherol occurs in concentrations of 0.1–0.3% in corn, rapeseed, soybean, sunflower, and wheat germ oils.Beta and gamma tocopherol are usually found in natural sources along with alpha tocopherol. Racemic synthetic tocopherols may be prepared by the condensation of the appropriate methylated hydroquinone with racemic isophytol.

Definition

ChEBI: 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-1-benzopyran-6-ol is a tocopherol.

General Description

TGF-β3 (transforming growth factor-β3) belongs to the TGF β superfamily. The TGFβ3 gene is mapped to human chromosome 14q24.3

Flammability and Explosibility

Non flammable

Pharmaceutical Applications

Alpha tocopherol is primarily recognized as a source of vitamin E, and the commercially available materials and specifications reflect this purpose. While alpha tocopherol also exhibits antioxidant properties, the beta, delta, and gamma tocopherols are considered to be more effective as antioxidants.
Alpha-tocopherol is a highly lipophilic compound, and is an excellent solvent for many poorly soluble drugs.Of widespread regulatory acceptability, tocopherols are of value in oil- or fat-based pharmaceutical products and are normally used in the concentration range 0.001–0.05% v/v. There is frequently an optimum concentration; thus the autoxidation of linoleic acid and methyl linolenate is reduced at low concentrations of alpha tocopherol, and is accelerated by higher concentrations. Antioxidant effectiveness can be increased by the addition of oil-soluble synergists such as lecithin and ascorbyl palmitate.
Alpha tocopherol may be used as an efficient plasticizer. It has been used in the development of deformable liposomes as topical formulations.
d-Alpha-tocopherol has also been used as a non-ionic surfactant in oral and injectable formulations.

Biochem/physiol Actions

TGF-β3 (transforming growth factor-β3) regulates lymphocyte proliferation, apoptosis, hematopoiesis and embryogenesis to maintain immune homeostasis. TGF-β plays an important role in cell growth, differentiation, and survival. TGF-β3 specifically promotes chondrogenic differentiation.TGF-β3 is a strong growth inhibitor for normal and transformed epithelial, lymphoid, fibroblast, and keratinocyte cells. TGF-2 inhibits antitumor action of NK (natural killer) cells, T-cells, macrophages, monocytes and neutrophils. TGF-β3 is a tumor suppressor in the early stages of carcinogenesis, but in the later stages acts as a tumor promoter by inducing epithelial-mesenchymal transition and stimulating angiogenesis. TGF-β isoforms is known to participate in wound healing and tissue fibrosis. TGF-β3 is crucial for tissue restoration and scarless tissue repair. Mutation in the TGFβ3 gene is associated with development of non-syndromic cleft palate only (NS CPO), a rare congenital disease.

Safety

Tocopherols (vitamin E) occur in many food substances that are consumed as part of the normal diet. The daily nutritional requirement has not been clearly defined but is estimated to be 3.0–20.0 mg. Absorption from the gastrointestinal tract is dependent upon normal pancreatic function and the presence of bile. Tocopherols are widely distributed throughout the body, with some ingested tocopherol metabolized in the liver; excretion of metabolites is via the urine or bile. Individuals with vitamin E deficiency are usually treated by oral administration of tocopherols, although intramuscular and intravenous administration may sometimes be used.
Tocopherols are well tolerated, although excessive oral intake may cause headache, fatigue, weakness, digestive disturbance, and nausea. Prolonged and intensive skin contact may lead to erythema and contact dermatitis.
The use of tocopherols as antioxidants in pharmaceuticals and food products is unlikely to pose any hazard to human health since the daily intake from such uses is small compared with the intake of naturally occurring tocopherols in the diet.
The WHO has set an acceptable daily intake of tocopherol used as an antioxidant at 0.15–2.0 mg/kg body-weight.

storage

Tocopherols are oxidized slowly by atmospheric oxygen and rapidly by ferric and silver salts. Oxidation products include tocopheroxide, tocopherylquinone, and tocopherylhydroquinone, as well as dimers and trimers. Tocopherol esters are more stable to oxidation than the free tocopherols but are in consequence less effective antioxidants.
Tocopherols should be stored under an inert gas, in an airtight container in a cool, dry place and protected from light.

Purification Methods

Dissolve dl--tocopherol in anhydrous MeOH (15mL/g) cool to -6o for 1hour, then chill in a Dry-ice/acetone bath; crystallisation is induced by scratching with a glass rod. The dl--acetate [52225-20-4] (see DL-vitamin E actetate below) is a viscous yellow liquid with m -7o, b 184o/0.01mm, 224o/0.3mm, d 4 20 0.953, n D 20 1.496. It is used as a standard for Vitamin E activity where the unit of activity is attained with 1mg of pure dl--acetate. [Friedrich “Vitamins” Water de Guyter Publ, Berlin 1988, Beilstein 17/4 V 168.]

Incompatibilities

Tocopherols are incompatible with peroxides and metal ions, especially iron, copper, and silver. Tocopherols may be absorbed into plastic.

Regulatory Status

GRAS listed. Accepted in Europe as a food additive. Included in the FDA Inactive Ingredients Database (IV injections, powder, lyophilized powder for liposomal suspension; oral capsules, tablets, and topical preparations). Included in the Canadian List of Acceptable Non-medicinal Ingredients. Included in nonparenteral medicines licensed in the UK.

DL-α-Tocopherol Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 512)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Mojin Biotechnology Co., Ltd
+8613288715578 sales@hbmojin.com China 12470 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177 peter@yan-xi.com China 6011 58
Sinoway Industrial co., ltd.
0592-5800732; +8613806035118 xie@china-sinoway.com China 992 58
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2503 58
airuikechemical co., ltd.
+undefined86-15315557071 sales05@airuikechemical.com China 994 58
Hebei Zhuanglai Chemical Trading Co.,Ltd
+8613343047651 admin@zlchemi.com China 2113 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21689 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555 +8617317452075 jack.li@time-chemicals.com China 1807 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479 sales@fine-chemtech.com CHINA 885 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +86-18949832763 info@tnjchem.com China 2989 55

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View Lastest Price from DL-α-Tocopherol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
DL-α-Tocopherol pictures 2024-05-24 DL-α-Tocopherol
10191-41-0
US $580.00-578.00 / kg 5kg 99% 100Tons Hebei Dangtong Import and export Co LTD
DL-α-Tocopherol pictures 2024-05-23 DL-α-Tocopherol
10191-41-0
US $85.00-45.00 / Kg/Bag 1Kg/Bag 98% up, High Density 20 tons Sinoway Industrial co., ltd.
DL-α-Tocopherol pictures 2024-05-14 DL-α-Tocopherol
10191-41-0
US $48.00 / kg 1kg 99% 5000kg/week Hebei Zhuanglai Chemical Trading Co.,Ltd
  • DL-α-Tocopherol pictures
  • DL-α-Tocopherol
    10191-41-0
  • US $580.00-578.00 / kg
  • 99%
  • Hebei Dangtong Import and export Co LTD
  • DL-α-Tocopherol pictures
  • DL-α-Tocopherol
    10191-41-0
  • US $85.00-45.00 / Kg/Bag
  • 98% up, High Density
  • Sinoway Industrial co., ltd.
  • DL-α-Tocopherol pictures
  • DL-α-Tocopherol
    10191-41-0
  • US $48.00 / kg
  • 99%
  • Hebei Zhuanglai Chemical Trading Co.,Ltd
3,4-dthydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2h-1-benzopyran-6-0l DL-VITAMIN E 98% NATURAL VITAMIN E(MIXED TOCOPHEROL) VITAMIN E OIL, 98% USP VitaminE50%Natural DL-ALFA-TOCOPHEROL 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)- alpha-tocopherol, 5,7,8-trimethyltocol dl-à-tocopherol DL-ALPHA-TOCOPHEROL,FCC VITAMINE,1MG=1.1IU,USP TOCOPHEROL,DL-ALPHA- ALL-RACEMIC-ALPHA-TOCOPHEROL VITAMIN E (DL-ALPHA TOCOPHEROL) DL-A-TOCOPHEROL USP DL-ALPHA-TOCOPHEROL (VITAMIN E) DL-A-TOCOPHEROL (DL-A-TOCOPHEROL, VITAMIN E) DL-ɑ-Tocopherol, 97% 2-(4,8,12-Trimethyltridecyl)-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran-6-ol 2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-1-benzopyran-6-ol DL-^a-Tocopherol, 97+% DL-alpha-Tocopherol, 97+% (±)-α-Tocopherol,DL-all-rac-α-Tocopherol, VitaminE, all-rac-α-Tocopherolum 1,2-DiaMino-3-Methylbenzene-d3 1-Methyl-2,3-phenylenediaMine-d3 2,3-ToluylenediaMine-d3 2,3-TolylenediaMine-d3 2-AMino-3-Methylaniline-d3 3-Methyl-1,2-benzenediaMine-d3 3-Methyl-1,2-diaMinobenzene-d3 Toluene-2,3-diaMine-d3 dl-a-Tocopheryl non-acetate DL-all-rac-α-Tocopherol, all-rac-α-Tocopherolum, VitaminE DL-all-rac-α-Tocopherol, VitaminE Mixed VitaMin E DL-alpha-Toco (±)?α?Tocopherol (Vitamin E) solution Anti-TGF β3 antibody produced in rabbit TGF-β-3 hTGF-β3 Transforming Growth Factor-β3 human 2-trans-enoyl-CoA isomerase Dodecenoyl-CoA isomerase Peroxisomal 3 δ(2)-enoyl-CoA isomerase Alpha Tocopherol (250 mg) Synthetic vitamin E oil ALPHA-TOCOPHEROL, >= 95.5% (+/-)-ALPHA-TOCOPHEROL (+/-)-ALPHA-TOCOFEROL ALPHA-TOCOPHEROLUM ALPHA-DL-TOCOPHEROL 5,7,8-TRIMETHYLTOCOL DL-VITAMIN E DL-VITAMIN E ALCOHOL DL-PHYTOGERMINE ecyl)- ephanyl