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DL-α-Tocopherol

DL-α-Tocopherol
DL-α-Tocopherol structure
CAS No.
10191-41-0
Chemical Name:
DL-α-Tocopherol
Synonyms
3,;8-(4;ecyl)-;ephanyl;TGF-β-3;hTGF-β3;A-TOCOPHEROL;DL-VITAMIN E;4-BroMo-2-(5;FIIN-​
CBNumber:
CB5275357
Molecular Formula:
C29H50O2
Formula Weight:
430.71
MOL File:
10191-41-0.mol

DL-α-Tocopherol Properties

Melting point:
2-4°C
alpha 
[α]D20 - 0.02 - +0.02゜ (neat)
Boiling point:
200-220°C 0,1mm
Density 
0.950 g/mL at 20 °C(lit.)
refractive index 
n20/D 1.506
Flash point:
240°C
storage temp. 
2-8°C
solubility 
H2O: insoluble
form 
Pale yellow oil
pka
11.40±0.40(Predicted)
Water Solubility 
Miscible with chloroform, vegetable oils, ether, acetone and alcohol. Immiscible with water.
Sensitive 
Light Sensitive
Merck 
14,9495
BRN 
94012
InChIKey
GVJHHUAWPYXKBD-IEOSBIPESA-N
CAS DataBase Reference
10191-41-0(CAS DataBase Reference)
EPA Substance Registry System
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)- (10191-41-0)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS02,GHS06,GHS08
Signal word  Danger
Hazard statements  H225-H301+H311+H331-H370
Precautionary statements  P210-P280-P302+P352+P312-P304+P340+P312-P370+P378-P403+P235
Hazard Codes  Xi,T,F
Risk Statements  36/37/38-39/23/24/25-23/24/25-11
Safety Statements  26-37/39-45-36/37-16-7
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  1
RTECS  GA8746000
8-10-23
TSCA  Yes
HS Code  29362800

DL-α-Tocopherol price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 258024 α-Tocopherol ≥95.5% 10191-41-0 5g $13 2020-08-18 Buy
Sigma-Aldrich 1667600 Alpha Tocopherol United States Pharmacopeia (USP) Reference Standard 10191-41-0 250mg $371 2020-08-18 Buy
TCI Chemical T0251 DL-α-Tocopherol >96.0%(GC) 10191-41-0 25g $25 2020-06-24 Buy
TCI Chemical T0251 DL-α-Tocopherol >96.0%(GC) 10191-41-0 250g $96 2020-06-24 Buy
Alfa Aesar A17039 DL-alpha-Tocopherol, 97+% 10191-41-0 50g $46.7 2020-06-24 Buy

DL-α-Tocopherol Chemical Properties,Uses,Production

Chemical Properties

1mg = 1.1 IU

Chemical Properties

Alpha tocopherol is a natural product. The PhEur 6.0 describes alpha-tocopherol as a clear, colorless or yellowish-brown, viscous, oily liquid.

Uses

dl-α-Tocopherol is the racemic analog of α-Tocopherol (T526125), the most bioactive of the naturally occurring forms of Vitamin E. Richest sources are green vegetables, grains, and oils, particularly palm, safflower and sunflower oils. dl-α-Tocopherol is an antioxidant that protects cell membrane lipids from oxidative damage.

Production Methods

Naturally occurring tocopherols are obtained by the extraction or molecular distillation of steam distillates of vegetable oils; for example, alpha tocopherol occurs in concentrations of 0.1–0.3% in corn, rapeseed, soybean, sunflower, and wheat germ oils.Beta and gamma tocopherol are usually found in natural sources along with alpha tocopherol. Racemic synthetic tocopherols may be prepared by the condensation of the appropriate methylated hydroquinone with racemic isophytol.

Pharmaceutical Applications

Alpha tocopherol is primarily recognized as a source of vitamin E, and the commercially available materials and specifications reflect this purpose. While alpha tocopherol also exhibits antioxidant properties, the beta, delta, and gamma tocopherols are considered to be more effective as antioxidants.
Alpha-tocopherol is a highly lipophilic compound, and is an excellent solvent for many poorly soluble drugs.Of widespread regulatory acceptability, tocopherols are of value in oil- or fat-based pharmaceutical products and are normally used in the concentration range 0.001–0.05% v/v. There is frequently an optimum concentration; thus the autoxidation of linoleic acid and methyl linolenate is reduced at low concentrations of alpha tocopherol, and is accelerated by higher concentrations. Antioxidant effectiveness can be increased by the addition of oil-soluble synergists such as lecithin and ascorbyl palmitate.
Alpha tocopherol may be used as an efficient plasticizer. It has been used in the development of deformable liposomes as topical formulations.
d-Alpha-tocopherol has also been used as a non-ionic surfactant in oral and injectable formulations.

Safety

Tocopherols (vitamin E) occur in many food substances that are consumed as part of the normal diet. The daily nutritional requirement has not been clearly defined but is estimated to be 3.0–20.0 mg. Absorption from the gastrointestinal tract is dependent upon normal pancreatic function and the presence of bile. Tocopherols are widely distributed throughout the body, with some ingested tocopherol metabolized in the liver; excretion of metabolites is via the urine or bile. Individuals with vitamin E deficiency are usually treated by oral administration of tocopherols, although intramuscular and intravenous administration may sometimes be used.
Tocopherols are well tolerated, although excessive oral intake may cause headache, fatigue, weakness, digestive disturbance, and nausea. Prolonged and intensive skin contact may lead to erythema and contact dermatitis.
The use of tocopherols as antioxidants in pharmaceuticals and food products is unlikely to pose any hazard to human health since the daily intake from such uses is small compared with the intake of naturally occurring tocopherols in the diet.
The WHO has set an acceptable daily intake of tocopherol used as an antioxidant at 0.15–2.0 mg/kg body-weight.

storage

Tocopherols are oxidized slowly by atmospheric oxygen and rapidly by ferric and silver salts. Oxidation products include tocopheroxide, tocopherylquinone, and tocopherylhydroquinone, as well as dimers and trimers. Tocopherol esters are more stable to oxidation than the free tocopherols but are in consequence less effective antioxidants.
Tocopherols should be stored under an inert gas, in an airtight container in a cool, dry place and protected from light.

Purification Methods

Dissolve dl--tocopherol in anhydrous MeOH (15mL/g) cool to -6o for 1hour, then chill in a Dry-ice/acetone bath; crystallisation is induced by scratching with a glass rod. The dl--acetate [52225-20-4] (see DL-vitamin E actetate below) is a viscous yellow liquid with m -7o, b 184o/0.01mm, 224o/0.3mm, d 4 20 0.953, n D 20 1.496. It is used as a standard for Vitamin E activity where the unit of activity is attained with 1mg of pure dl--acetate. [Friedrich “Vitamins” Water de Guyter Publ, Berlin 1988, Beilstein 17/4 V 168.]

Incompatibilities

Tocopherols are incompatible with peroxides and metal ions, especially iron, copper, and silver. Tocopherols may be absorbed into plastic.

Regulatory Status

GRAS listed. Accepted in Europe as a food additive. Included in the FDA Inactive Ingredients Database (IV injections, powder, lyophilized powder for liposomal suspension; oral capsules, tablets, and topical preparations). Included in the Canadian List of Acceptable Non-medicinal Ingredients. Included in nonparenteral medicines licensed in the UK.

DL-α-Tocopherol Preparation Products And Raw materials

Raw materials

Preparation Products


DL-α-Tocopherol Suppliers

Global( 266)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21869 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22623 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1365 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 2754 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30037 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28231 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 10375 58
hdzhl biotechnology co., ltd
86-13032617415
sales@luchibiology.com CHINA 1277 58

View Lastest Price from DL-α-Tocopherol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-05-29 Dl-Alpha Tocopherol (Vitamin E)
10191-41-0
US $0.00 / Kg/Drum 1KG 99% 200 tons hdzhl biotechnology co., ltd
2019-07-03 DL-α-Tocopherol
10191-41-0
US $1.00 / KG 1KG 98% 1kg,5kg,100kg career henan chemical co

DL-α-Tocopherol Spectrum


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