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Mefenamic acid

Description References
Mefenamic acid
Mefenamic acid structure
Chemical Name:
Mefenamic acid
HL 1;in-M;Pontal;CI 473;ci-473;CL 473;Coslan;Namphen;Ponalar;Ponstan
Molecular Formula:
Formula Weight:
MOL File:

Mefenamic acid Properties

Melting point:
230 °C
Boiling point:
384.06°C (rough estimate)
1.0944 (rough estimate)
refractive index 
1.5200 (estimate)
storage temp. 
Practically insoluble in water, slightly soluble in ethanol (96 per cent) and in methylene chloride. It dissolves in dilute solutions of alkali hydroxides
4.2(at 25℃)
Water Solubility 
It is soluble in acetone, chloroform, dichloromethane, methanol. Insoluble in water.
CAS DataBase Reference
61-68-7(CAS DataBase Reference)
NIST Chemistry Reference
Mefenamic acid(61-68-7)
  • Risk and Safety Statements
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330-P264-P270-P301+P312a-P330-P501a
Hazard Codes  Xn
Risk Statements  22-40-20/21/22
Safety Statements  22-36
WGK Germany  3
RTECS  CB4550000
HS Code  28142000
Toxicity LD50 orally in mice, rats: 630, 790 mg/kg (Jahn, Adrian)

Mefenamic acid price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 92574 Mefenamic acid analytical standard 61-68-7 250mg $66 2020-08-18 Buy
Sigma-Aldrich 1379605 Mefenamic acid United States Pharmacopeia (USP) Reference Standard 61-68-7 200mg $366 2020-08-18 Buy
TCI Chemical M1782 Mefenamic Acid >98.0%(T) 61-68-7 25g $27 2020-06-24 Buy
TCI Chemical M1782 Mefenamic Acid >98.0%(T) 61-68-7 100g $74 2020-06-24 Buy
Alfa Aesar J62705 Mefenamic acid, 98% 61-68-7 100g $97.2 2020-06-24 Buy

Mefenamic acid Chemical Properties,Uses,Production


Mefenamic acid is a kind of nonsteroidal anti-inflammatory (NSAID) drug belonging to the anthranilic acid derivatives class. It is mainly used for the short-term treatment of mild to moderate pain from various conditions. It is also used for reducing the pain and blood loss from menstrual condition as well as prevention of migraines. Moreover, it may also be used for treating gout attacks. Its mechanism is through inhibiting both the isoforms of COX and preventing the formation of prostaglandins. It is manufactured from 2-chlorobenzoic acid and 2,3-dimethylaniline. 


Chemical Properties

Light Yellow Solid


Ponstan,Parke Davis,UK,1963


For the treatment of rheumatoid arthritis, osteoarthritis, dysmenorrhea, and mild to moderate pain, inflammation, and fever.


Anti-inflammatory; analgesic.


Mefenamic acid (Ponstel) is indicated only for analgesia and primary dysmenorrhea when therapy will not exceed 1 week.


ChEBI: An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,3-dimethylphenyl group. Although classed as a non-steroidal anti-inflammatory drug, its anti-inflammatory properties are considered to b minor. It is used to relieve mild to moderate pain, including headaches, dental pain, osteoarthritis and rheumatoid arthritis.

Manufacturing Process

A mixture of 800 g of potassium o-bromo-benzoate, 1,500 ml of bis-(2- methoxyethyl)ether, 355 g of N-ethyl-morpholine, 375 g of 2,3- dimethylaniline, and 30 g of cupric acetate is heated gradually with stirring to 140°C over a period of 90 minutes. The hot reaction mixture is then acidified with 260 mi of concentrated hydrochloric acid and the acidified mixture divided into 2 equal portions. One liter of water is added to each portion and the mixtures allowed to cool. The N-(2,3-dimethylphenyl)anthranilic acid which separates upon cooling is collected by filtration and recrystallized from bis(2-methoxyethyl)ether; MP 229° to 230°C (corr.).

brand name

Ponstel (Sciele).

Therapeutic Function


Synthesis Reference(s)

The Journal of Organic Chemistry, 45, p. 2127, 1980 DOI: 10.1021/jo01299a020

General Description

Mefenamic acid (Ponstel, Ponstan) is one of the oldestNSAIDs, introduced into the market in 1967 for mild tomoderate pain and for primary dysmenorrhea. It is rapidly absorbed with peak plasma levels occurring 2 to 4 hoursafter oral administration. It undergoes hepatic benzylic hydroxylationof its 3'methyl group regioselectively into twoinactive metabolites, 3'-hydroxymethylmefenamic acid andthe 3'carboxylate metabolite (via further oxidation of thebenzylic alcohol group). The parent drugs and these metabolitesare conjugated with glucuronic acid and excreted primarilyin the urine. Thus, although patients with knownliver deficiency may be given lower doses, it is contraindicatedin patients with preexisting renal dysfunction.
Common side effects associated with its use include diarrhea,drowsiness, and headache. The possibility of blood disordershas also prompted limitation of its administration to 7days. It is not recommended for children or during pregnancy.

Clinical Use

Mefenamic acid is synthesized from o-chlorobenzoic acid and 2,3-dimethylaniline under catalytic conditions. Mefenamic acid is the only fenamic acid derivative that produces analgesia centrally and peripherally. Mefenamic acid is indicated for the short-term relief of moderate pain and for primary dysmenorrhea.


Mefenamic acid is absorbed rapidly following oral administration, with peak plasma levels being attained within 2 to 4 hours. It is highly bound to plasma proteins (78.5%) and has a plasma half-life of 2 to 4 hours. Metabolism occurs through regioselective oxidation of the 3′-methyl group and glucuronidation of mefenamic acid and its metabolites. Urinary excretion accounts for approximately 50 to 55% of an administered dose, with unchanged drug accounting for 6%, the 3′-hydroxymethyl metabolite (primarily as the glucuronide) accounting for 25%, and the remaining 20% as the dicarboxylic acid (of which 30% is the glucuronide conjugate). These metabolites are essentially inactive.

Mefenamic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Mefenamic acid Suppliers

Global( 268)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 22624 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 China 2754 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038 CHINA 3623 58
career henan chemical co
+86-371-86658258 CHINA 30039 58
Hubei Jusheng Technology Co.,Ltd.
027-59599243 CHINA 28231 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114 CHINA 6371 58
Hubei xin bonus chemical co. LTD
027-59338440 CHINA 23045 58
BOC Sciences
1-631-619-7922 1-631-619-7922
1-631-614-7828 United States 20039 58
Chongqing Chemdad Co., Ltd
+86-13650506873 CHINA 35434 58
Alchem Pharmtech,Inc.
8485655694 United States 63728 58

View Lastest Price from Mefenamic acid manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-04-29 Mefenamic acid
US $1.00-1.00 / KG 1g 99% 50tons Shaanxi Dideu Medichem Co. Ltd
2020-05-07 Mefenamic acid
US $1.00-1.00 / KG 1g 99% 50tons Shaanxi Dideu Medichem Co. Ltd
2018-12-15 Mefenamic acid
US $1.00 / kg 1kg 99% Customized career henan chemical co

Mefenamic acid Spectrum

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