ChemicalBook
Chinese Japanese Germany Korea

Mefenamic acid

Description References
Mefenamic acid
Mefenamic acid structure
CAS No.
61-68-7
Chemical Name:
Mefenamic acid
Synonyms
HL 1;in-M;CI 473;ci-473;CL 473;Coslan;Pontal;Bonabol;inf3355;Lysalgo
CBNumber:
CB5472051
Molecular Formula:
C15H15NO2
Formula Weight:
241.29
MOL File:
61-68-7.mol

Mefenamic acid Properties

Melting point:
230 °C
Boiling point:
384.06°C (rough estimate)
Density 
1.0944 (rough estimate)
refractive index 
1.5200 (estimate)
storage temp. 
Refrigerator
solubility 
Practically insoluble in water, slightly soluble in ethanol (96 per cent) and in methylene chloride. It dissolves in dilute solutions of alkali hydroxides
form 
neat
pka
4.2(at 25℃)
Water Solubility 
It is soluble in acetone, chloroform, dichloromethane, methanol. Insoluble in water.
Merck 
14,5798
CAS DataBase Reference
61-68-7(CAS DataBase Reference)
NIST Chemistry Reference
Mefenamic acid(61-68-7)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn
Risk Statements  22-40-20/21/22
Safety Statements  22-36
WGK Germany  3
RTECS  CB4550000
HS Code  28142000
Hazardous Substances Data 61-68-7(Hazardous Substances Data)
Toxicity LD50 orally in mice, rats: 630, 790 mg/kg (Jahn, Adrian)
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P330 Rinse mouth.

Mefenamic acid price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 92574 Mefenamic acid analytical standard 61-68-7 250mg $62.3 2018-11-13 Buy
Sigma-Aldrich 1379605 Mefenamic acid United States Pharmacopeia (USP) Reference Standard 61-68-7 200mg $348 2018-11-13 Buy
TCI Chemical M1782 Mefenamic Acid >98.0%(T) 61-68-7 25g $26 2018-11-22 Buy
TCI Chemical M1782 Mefenamic Acid >98.0%(T) 61-68-7 100g $72 2018-11-22 Buy
Alfa Aesar J62705 Mefenamic acid, 98% 61-68-7 100g $84.2 2018-11-13 Buy

Mefenamic acid Chemical Properties,Uses,Production

Description

Mefenamic acid is a kind of nonsteroidal anti-inflammatory (NSAID) drug belonging to the anthranilic acid derivatives class. It is mainly used for the short-term treatment of mild to moderate pain from various conditions. It is also used for reducing the pain and blood loss from menstrual condition as well as prevention of migraines. Moreover, it may also be used for treating gout attacks. Its mechanism is through inhibiting both the isoforms of COX and preventing the formation of prostaglandins. It is manufactured from 2-chlorobenzoic acid and 2,3-dimethylaniline. 

References

http://www.webmd.com/drugs/2/drug-11586/mefenamic-acid-oral/details
https://en.wikipedia.org/wiki/Mefenamic_acid

Chemical Properties

Light Yellow Solid

Uses

For the treatment of rheumatoid arthritis, osteoarthritis, dysmenorrhea, and mild to moderate pain, inflammation, and fever.

Uses

Anti-inflammatory; analgesic.

Indications

Mefenamic acid (Ponstel) is indicated only for analgesia and primary dysmenorrhea when therapy will not exceed 1 week.

Definition

ChEBI: An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,3-dimethylphenyl group. Although classed as a non-steroidal anti-inflammatory drug, its anti-inflammatory properties are considered to b minor. It is used to relieve mild to moderate pain, including headaches, dental pain, osteoarthritis and rheumatoid arthritis.

brand name

Ponstel (Sciele).

General Description

Mefenamic acid (Ponstel, Ponstan) is one of the oldestNSAIDs, introduced into the market in 1967 for mild tomoderate pain and for primary dysmenorrhea. It is rapidly absorbed with peak plasma levels occurring 2 to 4 hoursafter oral administration. It undergoes hepatic benzylic hydroxylationof its 3'methyl group regioselectively into twoinactive metabolites, 3'-hydroxymethylmefenamic acid andthe 3'carboxylate metabolite (via further oxidation of thebenzylic alcohol group). The parent drugs and these metabolitesare conjugated with glucuronic acid and excreted primarilyin the urine. Thus, although patients with knownliver deficiency may be given lower doses, it is contraindicatedin patients with preexisting renal dysfunction.
Common side effects associated with its use include diarrhea,drowsiness, and headache. The possibility of blood disordershas also prompted limitation of its administration to 7days. It is not recommended for children or during pregnancy.

Mefenamic acid Preparation Products And Raw materials

Raw materials

Preparation Products


Mefenamic acid Suppliers

Global( 226)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3203 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21910 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1752 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20642 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23982 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20094 58

View Lastest Price from Mefenamic acid manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-15 Mefenamic acid
61-68-7
US $1.00 / kg 1kg 99% Customized career henan chemical co

Mefenamic acid Spectrum


61-68-7(Mefenamic acid )Related Search:


Copyright 2017 © ChemicalBook. All rights reserved