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Application in Particular Diseases
Chemical Name:
Halt;ZK-A;Zacin;Adlea;Axsain;Mioton;Zostrix;CAPSAICIN;FEMA 2787;FEMA 3404
Molecular Formula:
Formula Weight:
MOL File:

Capsaicin Properties

Melting point:
62-65 °C(lit.)
Boiling point:
210-220 C
1.1037 (rough estimate)
refractive index 
1.5100 (estimate)
Flash point:
113 °C
storage temp. 
H2O: insoluble
Off-white solid
Water Solubility 
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
404-86-4(CAS DataBase Reference)
EPA Substance Registry System
6-Nonenamide, N-[(4-hydroxy-3-methoxyphenyl) methyl]-8-methyl-, (6E)-(404-86-4)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T,T+
Risk Statements  25-37/38-41-42/43-36/37/38
Safety Statements  22-26-28-36/39-45-36/37/39
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
RTECS  RA8530000
HazardClass  6.1(a)
PackingGroup  II
Hazardous Substances Data 404-86-4(Hazardous Substances Data)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger P280, P305+P351+P338, P310
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled Sensitisation, respiratory Category 1 Danger P261, P285, P304+P341, P342+P311,P501
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P284 Wear respiratory protection.

Capsaicin price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 12084 Capsaicin analytical standard for food analysis 404-86-4 10mg-f $50 2018-11-22 Buy
Sigma-Aldrich 1091108 Capsaicin United States Pharmacopeia (USP) Reference Standard 404-86-4 100mg $357.7 2018-11-20 Buy
TCI Chemical M1149 Capsaicin (Natural) >60.0%(HPLC) 404-86-4 1g $63 2018-11-22 Buy
Cayman Chemical 92350 Capsaicin ≥95% 404-86-4 100mg $69 2018-11-13 Buy
Cayman Chemical 92350 Capsaicin ≥95% 404-86-4 1g $311 2018-11-13 Buy

Capsaicin Chemical Properties,Uses,Production

Application in Particular Diseases

In Osteoarthritis:

Chemical Properties

Off-White Crystalline Solid

Chemical Properties

Crystalline solid, rectangular plates, or scales. Pungent odor and burning taste.


A representative lot is a 5:1 E:Z mixture. It is used as a tool in neurobiological research. Prototype vanilloid receptor agonist. Topical analgesic.


K channel blocker; multiple sclerosis therapy


analgesic (topical), depletes Substance P, neurotoxic


Capsaicin analogue (C175680). It is used as a tool in neurobiological research. Prototype vanilloid receptor agonist. Topical analgesic.


Capsaicin is used in many topical ointments used to relieve the pain of peripheral neuropathy (treatment of pain in the nerve endings near the surface of the skin).


As a tool in neurobiological research.

Biological Activity

Prototypic vanilloid receptor agonist (pEC 50 values are 7.97 and 7.10 at rat and human VR1 receptors respectively). Excites a subset of primary afferent sensory neurons, with subsequent antinociceptive and anti-inflammatory effects. Reversibly inhibits aggregation of platelets. Also available as part of the Vanilloid TRPV1 Receptor Tocriset™ .

Potential Exposure

Botanical animal and insect repellent used to repel birds, voles, deer, rabbits, squirrels, insects, and attacking dogs. Capsaicin, which is made from the Capsicum red chili pepper can be used indoors to protect carpets and upholstered furniture, and outdoors to protect fruit and vegetable crops, flowers, ornamental plants, shrubbery, trees, and lawns. It is also used in pepper sprays such as MACE, and as an analgesic in creams, lotions and solid sticks to reduce arthritic, postoperative and neuopathic pain, such as shingles. Capsaicin is obtained by grinding dried, ripe Capsicum frutescens L. chili peppers into a fine powder. The oleoresin is derived by distilling the powder in a solvent and evaporating the solvent. The resulting highly concentrated liquid has little odor but has an extremely pungent taste

First aid

Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin. Keep victim warm and quiet. Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. Medical observation is recommended for 24 to 48 hours after breathing overexposure, as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy.


UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Purification Methods

Recrystallise capcaicin from pet ether (b 40-60o), or pet ether/Et2O (9:1). Also purify it by chromatography on neutral Al2O3 (grade V) and elute successively with *C6H6, *C6H6/EtOAc (17:3) then *C6H6/EtOAc (7:3), and distil it at 120o/10-5mm, then repeatedly recrystallise the needles from isopropanol (charcoal). [Crombie et al. J Chem Soc 11025 1955, Bennett & Kirby J Chem Soc(C) 442 1968.] It causes pain and is neurotoxic [Bevan & Szolcsanyi Trends in Pharmacol Sci 11 330 1990, Beilstein 13 IV 2588].


Slowly hydrolyzes in water, releasing ammonia and forming acetate salts.

Waste Disposal

Do not discharge into drains or sewers. Dispose of waste material as hazardous waste using a licensed disposal contractor to an approved landfill. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Incineration with effluent gas scrubbing is recommended. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Noncombustible containers should be crushed and buried under more than 40 cm of soil. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office

Capsaicin Preparation Products And Raw materials

Raw materials

Preparation Products

Capsaicin Suppliers

Global( 321)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Nanjing Dolon Biotechnology Co.,Ltd.
18905173768 CHINA 2982 58
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 CHINA 3217 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 22049 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32651 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 CHINA 894 55
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 CHINA 14293 60
Hubei Jusheng Technology Co.,Ltd.
86-155-27864001 CHINA 18004 58
Qingdao Hongjin Trading Co., Ltd.
0532-83657313 CHINA 196 58
Chengdu Biopurify Phytochemicals Ltd.
18080483897 CHINA 2238 58

View Lastest Price from Capsaicin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-20 Capsaicin
US $1.00 / KG 1G 98% 100KG career henan chemical co
2018-08-10 Capsaicin
US $2.00 / KG 1KG 98% 10000kg career henan chemical co

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