Trimethyl phosphite

Trimethyl phosphite price More Price(18)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	8.00553	Trimethyl phosphite for synthesis	121-45-9	100 mL	$35.61	2021-03-22	Buy
Sigma-Aldrich	240907	Trimethyl phosphite ≥99%	121-45-9	25g	$35.8	2021-03-22	Buy
Sigma-Aldrich	8.00553	Trimethyl phosphite for synthesis	121-45-9	500 mL	$127.65	2021-03-22	Buy
Sigma-Aldrich	240907	Trimethyl phosphite ≥99%	121-45-9	100g	$85.4	2021-03-22	Buy
Alfa Aesar	030132	Trimethyl phosphite 97%	121-45-9	500g	$136	2021-03-22	Buy

Trimethyl phosphite Chemical Properties,Uses,Production

Chemical Properties

Trimethyl phosphite is a colorless liquid. Distinctive pungent, pyridine-like odor. The Odor Threshold is 0.0001 ppm.

Uses

Chemical intermediate, especially for insecticides.

Uses

Trimethyl phosphite is used in the manufacture of pesticides and fire retardants..

Uses

Used primarily in the synthesis of organophosphate insecticides; also used in the production of flame-retardant polymers and textiles.

Production Methods

Produced via a reaction between phosphorus trichloride and methanol in the presence of a tertiary amine catalyst such as diethylaniline.

General Description

A clear colorless liquid with a strong foul odor. Flash point 99°F. Denser than water and insoluble in waterwater; soluble in hexane, benzene, acetone, alcohol, ether, carbon tetrachloride, and kerosene.. Vapors heavier than air. Used to make other chemicals.

Air & Water Reactions

Highly flammable. Insoluble in water and denser than water. Slowly reacts with water to form phosphoric acid and corresponding organic alcohol.

Reactivity Profile

As soon as Trimethyl phosphite contacted a small amount of magnesium perchlorate in a flask, there was a flash and an explosion that shattered the flask (Allison 1968).

Health Hazard

Symptoms of exposure may include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting.

Health Hazard

Trimethyl phosphite is a skin, eye, and mucous membrane irritant with low subacute inhalation toxicity. Its irritating action on rabbits’ skin was moderate to severe. The pure liquid instilled into the eyes can cause severe irritation and swelling, which can last for a few days. Chronic exposure to 300–600 ppm concentration in air produced lung inflammation and cataracts in mice. There was no acute inhalation toxicity observed in test animals. The oral and dermal toxicities were low.
LD50 value, oral (rats): 1600 mg/kg
Teratogenic effects showing gross abnormalities were observed in newborn rats when pregnant rats were dosed with high concentrations of trimethyl phosphite.
The odor threshold for this compound was determined to be 0.0001 ppm (ACGIH 1986). The odor is irritating and pungent at high concentrations..

Fire Hazard

Special Hazards of Combustion Products: Toxic fumes of PO x

Safety Profile

Moderately toxic by ingestion and skin contact. An experimental teratogen. A severe skin and eye irritant. Flammable liquid when exposed to heat, flame, or oxidizers. To fight fire, use water, foam, fog, CO2. Violent explosive reaction on contact with magnesium perchlorate or trimethyl platinum(IV) azide tetramer. When heated to decomposition it emits toxic fumes of POx. An intermediate in the production of pesticides, fire retardants, and organic phosphorus additives. See also ESTERS.

Potential Exposure

Trimethyl phosphite is a flame retardant, and used as an intermediate in the manufacture of a number of pesticides, and organophosphorus additives.

Carcinogenicity

Trimethyl phosphite was genotoxic in mouse lymphoma assays but was not mutagenic in various bacterial assays.

Shipping

UN2329 Trimethyl phosphite, Hazard Class: 3; Labels: 3-Flammable liquid.

Purification Methods

Treat the phosphite with Na (to remove water and any dialkyl phosphonate), then decant and distil it with protection against moisture. It has also been treated with sodium wire for 24hours, then distilled in an inert atmosphere onto activated molecular sieves [Connor et al. J Chem Soc, Dalton Trans 511 1986]. It can be fractionally distilled using a spinning band column at high reflux ratio. It is a colourless liquid which is slowly hydrolysed by H2O. [Gillis et al. J Am Chem Soc 80 2999 1958, NMR: Callis et al. J Am Chem Soc 79 2719 1957, Kosolapoff Organophosphorus Compounds, Wiley p 203 1950, Beilstein 1 IV 1256.]

Incompatibilities

Vaor May form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Violent reaction with magnesium perchlorate. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Reacts (hydrolyzes) with water. Incompatible with air, moisture.

Waste Disposal

Trimethyl phosphite may be burned in a chemical incinerator equipped with an afterburner and scrubber.

Trimethyl phosphite Preparation Products And Raw materials

Raw materials

Preparation Products

Trimethyl phosphite Suppliers

Supplier	Tel	Fax	Email	Country	ProdList	Advantage
Hubei Jusheng Technology Co.,Ltd.	86-18871470254	027-59599243	linda@hubeijusheng.com	CHINA	28229	58
Hebei Guanlang Biotechnology Co., Ltd.	+8619930503282		sales3@crovellbio.com	China	5361	58
Hubei xin bonus chemical co. LTD	86-13657291602	027-59338440	linda@hubeijusheng.com	CHINA	23035	58
Chongqing Chemdad Co., Ltd	+86-13650506873		sales@chemdad.com	CHINA	37282	58
HENAN BON INDUSTRIAL CO.,LTD	0371-55170695		info@hnbon.com	CHINA	26742	58
CONIER CHEM AND PHARMA LIMITED	86-18523575427		sales@conier.com	CHINA	47496	58
Career Henan Chemica Co	13203830695 0371-86658258	0371-86658258	Laboratory@coreychem.com	CHINA	30281	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	0551-65418697	sales@tnjchem.com	CHINA	37441	58
AFINE CHEMICALS LIMITED	008657185134551	008657185134895	info@afinechem.com	CHINA	15559	58
Zhuoer Chemical Co., Ltd	+86-13524231522	+86-21-58816016	sales@zhuoerchem.com	CHINA	3014	58

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