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Trimethyl phosphite

Trimethyl phosphite
Trimethyl phosphite structure
CAS No.
121-45-9
Chemical Name:
Trimethyl phosphite
Synonyms
P(OMe)3;P(OCH3)3;AURORA KA-1230;Trimethylfosfit;Trimethoxyfosfin;METHYL PHOSPHITE;TrimethyPhosphite;Trimethylphosphit ;TRIMETHYL PHOSPHITE;TRIMETHYLPHOSPHIT S
CBNumber:
CB7100684
Molecular Formula:
C3H9O3P
Formula Weight:
124.08
MOL File:
121-45-9.mol

Trimethyl phosphite Properties

Melting point:
−78 °C(lit.)
Boiling point:
111-112 °C(lit.)
Density 
1.052 g/mL at 25 °C(lit.)
vapor density 
4.3 (vs air)
vapor pressure 
17 mm Hg ( 20 °C)
refractive index 
n20/D 1.408(lit.)
Flash point:
82 °F
storage temp. 
2-8°C
form 
Liquid
color 
Colorless
Specific Gravity
1.052
explosive limit
5.2-61.2%(V)
Water Solubility 
Hydrolyzes with water.
Sensitive 
Air & Moisture Sensitive
Hydrolytic Sensitivity
4: no reaction with water under neutral conditions
BRN 
956570
Exposure limits
TLV-TWA 10 mg/m3 (2 ppm) (ACGIH).
CAS DataBase Reference
121-45-9(CAS DataBase Reference)
FDA UNII
26Q0321ZDG
NIST Chemistry Reference
Phosphorous acid, trimethyl ester(121-45-9)
EPA Substance Registry System
Trimethyl phosphite (121-45-9)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS02,GHS05,GHS07,GHS08
Signal word  Danger
Hazard statements  H226-H302-H315-H317-H318-H335-H341-H351-H313-H319-H361
Precautionary statements  P201-P303+P361+P353-P405-P501a-P210-P280-P301+P312+P330-P305+P351+P338+P310-P370+P378-P261-P305+P351+P338
Hazard Codes  Xn,T,F,Xi
Risk Statements  10-22-36/37/38-41-37/38-65-48/23/24/25-11-46-45-67-66-36
Safety Statements  26-39-62-45-16-53
RIDADR  UN 2329 3/PG 3
WGK Germany  1
RTECS  TH1400000
10-13-21
Autoignition Temperature 250 °C
TSCA  Yes
HS Code  2920 23 00
HazardClass  3
PackingGroup  III
Toxicity LD50 orally in Rabbit: 1600 mg/kg LD50 dermal Rabbit 2600 mg/kg
NFPA 704
3
1 1

Trimethyl phosphite price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.00553 Trimethyl phosphite for synthesis 121-45-9 100 mL $35.61 2021-03-22 Buy
Sigma-Aldrich 240907 Trimethyl phosphite ≥99% 121-45-9 25g $35.8 2021-03-22 Buy
Sigma-Aldrich 8.00553 Trimethyl phosphite for synthesis 121-45-9 500 mL $127.65 2021-03-22 Buy
Sigma-Aldrich 240907 Trimethyl phosphite ≥99% 121-45-9 100g $85.4 2021-03-22 Buy
Alfa Aesar 030132 Trimethyl phosphite 97% 121-45-9 500g $136 2021-03-22 Buy

Trimethyl phosphite Chemical Properties,Uses,Production

Chemical Properties

Trimethyl phosphite is a colorless liquid. Distinctive pungent, pyridine-like odor. The Odor Threshold is 0.0001 ppm.

Uses

Chemical intermediate, especially for insecticides.

Uses

Trimethyl phosphite is used in the manufacture of pesticides and fire retardants..

Uses

Used primarily in the synthesis of organophosphate insecticides; also used in the production of flame-retardant polymers and textiles.

Production Methods

Produced via a reaction between phosphorus trichloride and methanol in the presence of a tertiary amine catalyst such as diethylaniline.

General Description

A clear colorless liquid with a strong foul odor. Flash point 99°F. Denser than water and insoluble in waterwater; soluble in hexane, benzene, acetone, alcohol, ether, carbon tetrachloride, and kerosene.. Vapors heavier than air. Used to make other chemicals.

Air & Water Reactions

Highly flammable. Insoluble in water and denser than water. Slowly reacts with water to form phosphoric acid and corresponding organic alcohol.

Reactivity Profile

As soon as Trimethyl phosphite contacted a small amount of magnesium perchlorate in a flask, there was a flash and an explosion that shattered the flask (Allison 1968).

Health Hazard

Symptoms of exposure may include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting.

Health Hazard

Trimethyl phosphite is a skin, eye, and mucous membrane irritant with low subacute inhalation toxicity. Its irritating action on rabbits’ skin was moderate to severe. The pure liquid instilled into the eyes can cause severe irritation and swelling, which can last for a few days. Chronic exposure to 300–600 ppm concentration in air produced lung inflammation and cataracts in mice. There was no acute inhalation toxicity observed in test animals. The oral and dermal toxicities were low.
LD50 value, oral (rats): 1600 mg/kg
Teratogenic effects showing gross abnormalities were observed in newborn rats when pregnant rats were dosed with high concentrations of trimethyl phosphite.
The odor threshold for this compound was determined to be 0.0001 ppm (ACGIH 1986). The odor is irritating and pungent at high concentrations..

Fire Hazard

Special Hazards of Combustion Products: Toxic fumes of PO x

Safety Profile

Moderately toxic by ingestion and skin contact. An experimental teratogen. A severe skin and eye irritant. Flammable liquid when exposed to heat, flame, or oxidizers. To fight fire, use water, foam, fog, CO2. Violent explosive reaction on contact with magnesium perchlorate or trimethyl platinum(IV) azide tetramer. When heated to decomposition it emits toxic fumes of POx. An intermediate in the production of pesticides, fire retardants, and organic phosphorus additives. See also ESTERS.

Potential Exposure

Trimethyl phosphite is a flame retardant, and used as an intermediate in the manufacture of a number of pesticides, and organophosphorus additives.

Carcinogenicity

Trimethyl phosphite was genotoxic in mouse lymphoma assays but was not mutagenic in various bacterial assays.

Shipping

UN2329 Trimethyl phosphite, Hazard Class: 3; Labels: 3-Flammable liquid.

Purification Methods

Treat the phosphite with Na (to remove water and any dialkyl phosphonate), then decant and distil it with protection against moisture. It has also been treated with sodium wire for 24hours, then distilled in an inert atmosphere onto activated molecular sieves [Connor et al. J Chem Soc, Dalton Trans 511 1986]. It can be fractionally distilled using a spinning band column at high reflux ratio. It is a colourless liquid which is slowly hydrolysed by H2O. [Gillis et al. J Am Chem Soc 80 2999 1958, NMR: Callis et al. J Am Chem Soc 79 2719 1957, Kosolapoff Organophosphorus Compounds, Wiley p 203 1950, Beilstein 1 IV 1256.]

Incompatibilities

Vaor May form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Violent reaction with magnesium perchlorate. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Reacts (hydrolyzes) with water. Incompatible with air, moisture.

Waste Disposal

Trimethyl phosphite may be burned in a chemical incinerator equipped with an afterburner and scrubber.

Trimethyl phosphite Preparation Products And Raw materials

Raw materials

Preparation Products


Trimethyl phosphite Suppliers

Global( 165)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5361 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58
Chongqing Chemdad Co., Ltd
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HENAN BON INDUSTRIAL CO.,LTD
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CONIER CHEM AND PHARMA LIMITED
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Career Henan Chemica Co
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Hefei TNJ Chemical Industry Co.,Ltd.
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0551-65418697 sales@tnjchem.com CHINA 37441 58
AFINE CHEMICALS LIMITED
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008657185134895 info@afinechem.com CHINA 15559 58
Zhuoer Chemical Co., Ltd
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View Lastest Price from Trimethyl phosphite manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-09-28 Trimethyl phosphite
121-45-9
US $10.00 / KG 1KG 99% 5tons Hebei Guanlang Biotechnology Co., Ltd.

Trimethyl phosphite Spectrum


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