Lisinopril | 76547-98-3

Lisinopril Properties

Melting point	162-165 °C
Boiling point	666.4±55.0 °C(Predicted)
Density	1.251±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	H₂O: ≥10 mg/mL
pka	2.18±0.10(Predicted)
form	solid
color	white
BCS Class	3
CAS DataBase Reference	76547-98-3(CAS DataBase Reference)
FDA UNII	7Q3P4BS2FD
NCI Dictionary of Cancer Terms	Prinivil; Zestril
NCI Drug Dictionary	Prinivil

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS08

Signal word

Warning

Hazard statements

H361-H373

Precautionary statements

P201-P202-P260-P280-P308+P313-P405-P501

Safety Statements

22-24/25

WGK Germany

3

RTECS

TW3589990

NFPA 704

	0
2		0

Lisinopril price More Price(18)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	16833	Lisinopril ≥98%	76547-98-3	1g	$70	2024-03-01	Buy
Cayman Chemical	16833	Lisinopril ≥98%	76547-98-3	5g	$299	2024-03-01	Buy
Cayman Chemical	16833	Lisinopril ≥98%	76547-98-3	100mg	$11	2024-03-01	Buy
Cayman Chemical	16833	Lisinopril ≥98%	76547-98-3	500mg	$40	2024-03-01	Buy
Activate Scientific	AS112353	Lisinopril 96%	76547-98-3	5G	$342	2021-12-16	Buy

Product number	Packaging	Price	Buy
16833	1g	$70	Buy
16833	5g	$299	Buy
16833	100mg	$11	Buy
16833	500mg	$40	Buy
AS112353	5G	$342	Buy

Lisinopril Chemical Properties,Uses,Production

Description

Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor (IC₅₀ = 1.2 nM). It reduces the formation of endothelin-1 and increases nitric oxide (NO) in human vascular endothelial cells when used at a concentration of 0.1 nM. Lisinopril inhibits the pressor response to angiotensin I in anesthetized rats and dogs (ID₅₀s = 2.3 and 6.5 μg/kg, respectively).

Originator

Acebitor 5,Biddle Sawyer,India

Uses

Labeled Lisinopril, intended for use as an internal standard for the quantification fo Lisinopril by GC- or LC-mass spectrometry.

Uses

Lisinopril is an antihypertensive medication.

Definition

ChEBI: Lisinopril is a dipeptide. It has a role as an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor. It contains a L-prolino group and a L-lysine residue.

Manufacturing Process

2-Oxo-4-phenylbutyric acid and t-BOC-L-lysyl-L-proline are condensed in the presence of sodium cyanoborohydride. Essentially all of the t-BOC protecting group is cleaved when the product is absorbed on strong acid ion exchange resin. The crude N-(1-carboxy-3-phenylpropyl)-L-lysyl-L-proline is eluted from the resin with 10% ammonia, freeze dried, and purified by gel filtration chromatography (LH-20). A minute peak for t-BOC protons in the NMR spectrum disappears when the product is treated with ethyl acetate that is 4 N in hydrogen chloride gas. The NMR spectrum of the resulting HCl salt of the product is consistent with structure. The mass spectrum shows a molecular ion at 693 m/e for the tetrasilylated species. Chromatography on XAD-2 resin using 3.5% acetonitrile in 0.1 molar ammonium hydroxide affords N-α-((1S)- 1-carboxy-3-phenylpropyl)-L-lysyl-L-proline. The last peptide can be produced if 2-oxo-4-phenylbutyric acid and N-t-Boc-L-lysyl-L-proline are condensed in the presence of sodium cyanoborohydride. The product is absorbed on strong acid ion exchange resin, and eluted with 2% pyridine in water. Product-rich cuts are stripped to a glass and treated with 4 N HCl in ethylacetate to remove the t-Boc protecting group. The resulting hydrochloride salt is converted to the free base by absorbing on strong acid ion exchange resin and eluting with 2% pyridine in water. Freeze drying of product-rich cuts affords N-α-(1-carboxy-3-phenylpropyl)-L-lysyl-L-proline as a white fluffy solid. The NMR spectrum is consistent with structure. The mass spectrum shows a molecular ion at 549 for the disilylated species. Chromatography affords the desired isomer.

brand name

Prinivil (Merck); Zestril (AstraZeneca).

Therapeutic Function

Antihypertensive

Lisinopril Preparation Products And Raw materials

Raw materials

L-Lysine Trifluoroacetic acid L-Proline Sodium cyanoborohydride LIPOPHILIC SEPHADEX

2-Oxo-4-phenylbutyric acid

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Preparation Products

Lisinopril Suppliers

Global( 207)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	9320	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29220	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58
Baoji Guokang Bio-Technology Co., Ltd.	0917-3909592 13892490616	gksales1@gk-bio.com	China	9339	58
XI'AN TIANGUANGYUAN BIOTECH CO., LTD.	+86-029-86333380 18829239519	sales06@tgybio.com	China	959	58
sgtlifesciences pvt ltd	+8617013299288	dj@sgtlifesciences.com	China	12382	58

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Chongqing Chemdad Co., Ltd	58
TargetMol Chemicals Inc.	58
Shaanxi Dideu Medichem Co. Ltd	58
Dideu Industries Group Limited	58
AFINE CHEMICALS LIMITED	58
Baoji Guokang Bio-Technology Co., Ltd.	58
XI'AN TIANGUANGYUAN BIOTECH CO., LTD.	58
sgtlifesciences pvt ltd	58

View Lastest Price from Lisinopril manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-02-22	Lisinopril 76547-98-3	US $60.00 / kg	1kg	99%	100 tons	Hebei Duling International Trade Co. LTD
2021-08-11	Lisinopril USP/EP/BP 76547-98-3	US $1.10 / g	1g	99.9%	100 Tons min	Dideu Industries Group Limited
2021-07-13	Lisinopril 76547-98-3	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

Lisinopril
76547-98-3
US $60.00 / kg
99%
Hebei Duling International Trade Co. LTD

Lisinopril USP/EP/BP
76547-98-3
US $1.10 / g
99.9%
Dideu Industries Group Limited

Lisinopril
76547-98-3
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Lisinopril Spectrum

Lisinopril(76547-98-3)¹HNMR

76547-98-3(Lisinopril)Related Search:

D-Proline DL-Lysine acetylsalicylate Poly(L-lysine hydrobromide) L-Lysine hydrochloride L-Lysine

LISINOPRIL ESTER,LISINOPRIL (ETHYL) ESTER Lisinopril Dihydrate N6-Trrifluoroacetyl-L-lysine(for Lisinopril),N-6-TRIFLUORO ACETYL-L-LYSINE ( LISINOPRIL INTERMEDIATE ) Lisinopril R,S,S-Diketopiperazine N6-TRIFLUOROACETYL-L-LYSINE /INTERMEDIATE OF LISINOPRIL

N6-TrifluoroAcetyl-L-Lysine,Lisinopril N∑-BENZYLOXYCARBONYL-L-LYSINYL-L-PROLINE(LISINOPRIL INTERMEDIATE) (R) Lisinopril (S)Lisinopril-D5 LISINOPRIL DIHYDRATE FOR PERFORMANCE TEST

Lisinopril S,S,S-Diketopiperazine Lisinopril LISINOPRIL DIKETOPIPERAZINE

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(S)-1-[(S)-6-AMINO-2-((S)-1-CARBOXY-3-PHENYL-PROPYLAMINO)-HEXANOYL]-PYRROLIDINE-2-CARBOXYLIC ACID TENSOPRIL VIVATEC ZESTRIL mk522 PRINIL PRINIVIL n-{n-[(s)-1-carboxy-3-phenylpropyl]-l-lysyl}-l-proline NOVATEC MK-521 mk-0521 N-(1(S)-Carboxy-3-phenylpropyl)-L-lysyl-L-proline N2-[(S)-1-Carboxy-3-phenylpropyl]-L-lysyl-L-proline Noperten Presiten Prinvil Tensyn Lisinopril N2-[(S)-1-Carboxy-3-phenylpropyl]-L-Lys-L-Pro-OH·2hydrate 1-[N2-[(S)-1-Carboxy-3-phenylpropyl]-L-lysyl]-L-proline Longes N2-[(S)-1-Carboxy-3-phenylpropyl]-L-Lys-L-Pro-OH (S)-Nα-(1-Carboxy-3-phenylpropyl)-Lys-Pro lisinopri LISINOPRIL DIHYDRATE ASSAY STANDARD BP(CRM STANDARD) LISINOPRIL DIHYDRATE BP LISINOPRIL DIHYDRATE BP STANDARD(CRM STANDARD) LISINOPRIL DIHYDRATE EPL LISINOPRIL DIHYDRATE EPL(CRM STANDARD) LISINOPRIL DIHYDRATE IMP. A (EP): (2RS)-2-AMINO-4-PHENYLBUTANOIC ACID MM LISINOPRIL DIHYDRATE IMP. A (EP): (2RS)-2-AMINO-4-PHENYLBUTANOIC ACID MM(CRM STANDARD) LISINOPRIL USP LISINOPRIL USP(CRM STANDARD) Cipral Inopril Linopril Linvas Lisoril Lispril Listril L-Proline, 1-[N2-(1-carboxy-3-phenylpropyl)-L-lysyl]-, (S)- L-Proline, N2-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl- (9CI) (s)-1-(n(sup2)-(1-carboxy-3-phenylpropyl)-l-lysyl)-l-proline lysinopril mk0521 CORIC CARACE ACERBON ALAPRIL Lisinopril USP24,EPIII Lisinopril EP Impurity G (2S)-1-[(2S)-6-amino-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]-1-oxohexyl]-2-pyrrolidinecarboxylic acid Lisinopril, >99% LISINOPRIL (MK-521) Lisinopril Dihydrate, 98.0+ % (HPLC) L-Proline, N2-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl- Lisinopril USP/EP/BP (S)-Lisinopril DISCONTINUED