Otenabant
- CAS No.
- 686344-29-6
- Chemical Name:
- Otenabant
- Synonyms
- CS-1072;otenabant;Otenabant, >=98%;CP945598 free base;Otenabant (CP-945,598);CP 945598;OTENABANT;CP945598;CP 945598; CP-945598; CP945598;Otenabant (CP-945598 free base);1-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxamide;4-Piperidinecarboxamide, 1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-(ethylamino)-
- CBNumber:
- CB61518526
- Molecular Formula:
- C25H25Cl2N7O
- Molecular Weight:
- 510.42
- MDL Number:
- MOL File:
- 686344-29-6.mol
| Boiling point | 757.9±70.0 °C(Predicted) |
|---|---|
| Density | 1.46 |
| storage temp. | Store at -20°C |
| solubility | DMSO : 100 mg/mL (195.92 mM; Need ultrasonic) |
| form | Powder |
| pka | 16.30±0.20(Predicted) |
| FDA UNII | J8211Y53EF |
Otenabant price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-1279 | Otenabant 99.33% | 686344-29-6 | 5mg | $84 | 2021-12-16 | Buy |
| ChemScene | CS-1279 | Otenabant 99.33% | 686344-29-6 | 10mg | $119 | 2021-12-16 | Buy |
| ApexBio Technology | A3691 | Otenabant | 686344-29-6 | 10mg | $156 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0006009 | CP-945598 95.00% | 686344-29-6 | 10MG | $305.55 | 2021-12-16 | Buy |
| ChemScene | CS-1279 | Otenabant 99.33% | 686344-29-6 | 50mg | $396 | 2021-12-16 | Buy |
Otenabant Chemical Properties,Uses,Production
Biological Activity
Otenabant is a potent and selective cannabinoid receptor CB1 antagonist with a Ki of 0.7 nM, more than 1000-fold selective for CB2.
in vitro
Otenabant HCl has low affinity with K i of 7.6 μM for human CB2 receptors. It inhibits CB1 receptor with moderate unbound microsomal clearance, low hERG affinity, and adequate CNS penetration. < /p>
in vivo
Otenabant acutely stimulates energy expenditure in rats and decreases the respiratory quotient indicating a metabolic switch to increased fat oxidation. It (10 mg/kg, po) promotes a 9%, vehicle adjusted weight loss in a 10 day weight loss study in diet-induced obese mice. Otenabant HCl reverses four cannabinoid agonistmediated behaviors (locomotor activity, hypothermia, analgesia, and catalepsy) following administration of the synthetic CB1 receptor agonist CP-55940. And Otenabant HCl exhibits dose-dependent anorectic activity in a model of acute food intake in rodents and increased energy expenditure and fat oxidation.
target
Ki: 0.7 nM (CB1)
Otenabant Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9338 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
View Lastest Price from Otenabant manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-13 | Otenabant
686344-29-6
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-09 | Otenabant
686344-29-6
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |