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Ellagic acid

Ellagic acid
Ellagic acid structure
CAS No.
476-66-4
Chemical Name:
Ellagic acid
Synonyms
Ellagic;lagistase;c.i.55005;c.i.75270;eleagicacid;ELLAGIC ACID;elagostasine;Elllagic Acid;AKOS NCG1-0028;BENZOARIC ACID
CBNumber:
CB6214708
Molecular Formula:
C14H6O8
Formula Weight:
302.19
MOL File:
476-66-4.mol

Ellagic acid Properties

Melting point:
≥350 °C
Boiling point:
363.24°C (rough estimate)
Density 
1.667
refractive index 
1.5800 (estimate)
storage temp. 
Store at RT
solubility 
1 M NaOH: 10 mg/mL, dark green
form 
powder
color 
tan to gray
Water Solubility 
<0.1 g/100 mL at 21 ºC
Sensitive 
Air & Light Sensitive
Merck 
14,3547
BRN 
47549
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey
AFSDNFLWKVMVRB-UHFFFAOYSA-N
CAS DataBase Reference
476-66-4(CAS DataBase Reference)
EPA Substance Registry System
Ellagic acid (476-66-4)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-36/37
WGK Germany  3
RTECS  DJ2620000
8-10-23
HS Code  29322090
Toxicity LD50 oral in rat: > 20gm/kg

Ellagic acid price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 14668 Ellagic acid analytical standard 476-66-4 50mg $101 2018-11-13 Buy
Sigma-Aldrich 05350590 Ellagic acid primary reference standard 476-66-4 50mg $299 2018-11-13 Buy
Alfa Aesar A15722 Ellagic acid hydrate, 97%, may cont. up to 12% water 476-66-4 25g $147 2018-11-13 Buy
Alfa Aesar A15722 Ellagic acid hydrate, 97%, may cont. up to 12% water 476-66-4 5g $41.4 2018-11-13 Buy
Cayman Chemical 10569 Ellagic Acid ≥95% 476-66-4 100mg $14 2018-11-13 Buy

Ellagic acid Chemical Properties,Uses,Production

Chemical Properties

cream to light yellow crystalline solid

Uses

hemostatic, antineoplastic, antimutagenic

Uses

Ellagic Acid is a phenol antioxidant found naturally in various fruits and vegetables. Ellagic Acid was shown to exhibit high levels of antiproliferative and antioxidant properties in studies, which s uggests its potential health benefits following ellagic acid consumption.

Definition

ChEBI: An organic heterotetracyclic compound resulting from the formal dimerisation of gallic acid by oxidative aromatic coupling with intramolecular lactonisation of both carboxylic acid groups of the resulting biaryl. It is found in many fruits and vegetables, ncluding raspberries, strawberries, cranberries, and pomegranates.

General Description

Cream-colored needles (from pyridine) or yellow powder. Odorless.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Ellagic acid reacts as a weak acid. Incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated. Heat is also generated by the acid-base reaction between phenols and bases. May be sulfonated exothermically very readily (for example, by concentrated sulfuric acid at room temperature). May be nitrated very rapidly, even by dilute nitric acid.

Fire Hazard

Flash point data for Ellagic acid are not available; however, Ellagic acid is probably combustible.

Biological Activity

Selective, ATP-competitive inhibitor of casein kinase 2 (CK2) (IC 50 values are 40, 2900, 3500, 4300 and 9400 nM for CK2, Lyn, PKA, Syk? and FGR respectively). Exhibits antioxidant, antitumor and anticarcinogenic activity and also inhibits glutathione S-transferase.

Anticancer Research

Ellagic acid is a naturally occurring phenolic constituent present in natural productsand nuts, most elevated amounts of which are found in raspberries (Daniel et al.1990). EA is considered as a potent anticarcinogenic and antimutagenic compound.EA shows anti-angiogenic property by repressing PDGF-R movement and phosphorylationof its substrate. It can intrude with endothelial cell-associated VEGR-2phosphorylation bringing about the restraint of the downstream signaling activatedby this receptor and in the hindrance of two key events fundamental in angiogenesis,i.e., EC movement and morphogenic separation into capillary-like structure. In parallel,EA indicated robust inhibitory activity against perivascular cells through itsrestraint of PDGF-R action and signaling prompting hindrance of VSMC relocation(Labrecque et al. 2005).
It is a phenolic compound extracted from pomegranate. It is an antiproliferative andantioxidant compound (Murakami et al. 1996). It induces apoptosis in cancer cellsof the prostate and breast and prevents the process of metastasis in different cancers(Singh et al. 2016b).

Purification Methods

This antioxidant crystallises from pyridine. It forms a dark green solution in aqueous N NaOH. The tetraactetate dilactone crystallises from Ac2O, with m 340o. [Beilstein 19 H 261, 19 III/IV 3164, 19/7 V 108.]

Ellagic acid Preparation Products And Raw materials

Raw materials

Preparation Products


Ellagic acid Suppliers

Global( 346)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Kono Chem Co., Ltd
+86-132 8924 6953(Whatsapp/Wechat)
+86-29-86107037 info@konochemical.com CHINA 2994 58
Shaanxi Pioneer Biotech Co., Ltd .
86-13259417953(Whatsapp)
029-84385017 sales@pioneerbiotech.com CHINA 3029 58
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3194 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21667 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sale@mainchem.com CHINA 32447 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 892 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1861 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29999 58

View Lastest Price from Ellagic acid manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-15 Ellagic acid 476-66-4
476-66-4
US $24.00 / mg 20mg ≥98% 1000.00 kgs NanJing Spring & Autumn Biological Engineering CO., LTD.
2018-08-10 Ellagic acid
476-66-4
US $2.00 / KG 1KG 98% 10000kg career henan chemical co
2019-07-02 Ellagic acid 476-66-4
476-66-4
US $62.00 / KG 100g ≥98% 1000.00 kgs NanJing Spring & Autumn Biological Engineering CO., LTD.

Ellagic acid Spectrum


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