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Clindamycin hydrochloride

Overview Pharmacokinetics Indication Mode of action Adverse reactions Warning and risk References
Clindamycin hydrochloride
Clindamycin hydrochloride structure
Chemical Name:
Clindamycin hydrochloride
CLEOCIN;Dalacin;U-21251F;dalacina;Dalacin S;Lujiemycin;Clidamacin;Panancocin;CLINDAMYCIN HC;ClindaMycin-d3
Molecular Formula:
Formula Weight:
MOL File:

Clindamycin hydrochloride Properties

Melting point:
storage temp. 
H2O: 50 mg/mL, clear, colorless
CAS DataBase Reference
21462-39-5(CAS DataBase Reference)
  • Risk and Safety Statements
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-37/39
WGK Germany  2
RTECS  GF2275000
HS Code  29419000

Clindamycin hydrochloride price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C5269 Clindamycin hydrochloride lincosamide antibiotic 21462-39-5 10mg $76.2 2018-11-13 Buy
Sigma-Aldrich C5269 Clindamycin hydrochloride lincosamide antibiotic 21462-39-5 50mg $221 2018-11-13 Buy
Sigma-Aldrich C5269 Clindamycin hydrochloride lincosamide antibiotic 21462-39-5 100mg $370 2018-11-13 Buy
Sigma-Aldrich C2250000 Clindamycin hydrochloride European Pharmacopoeia (EP) Reference Standard 21462-39-5 c2250000 $179 2018-11-23 Buy

Clindamycin hydrochloride Chemical Properties,Uses,Production


Clindamycin [7-chloro-lincomycin] is a semisynthetic derivative of lincomycin and was introduced in the 1960s as an antibiotic. It is available as clindamycin hydrochloride for oral administration in capsules, as clindamycin phosphate for intramuscular or intravenous injection, and as clindamycin palmitate for oral suspensions[3-5]. In vitro, its spectrum of activity includes staphylococci, streptococci and pneumococci, most anaerobic bacteria [including over 90% of Bacteroides fragilis], Chlamydia trachomatis and certain protozoa. Like penicillin, it has activity against group A and B streptococci, microaerophilic streptococci and most Streptococcus pneumoniae. It does not, however, have activity against the enterococci [3-5]. Like cloxacillin and the cephalosporins, clindamycin possesses activity against Staphylococcus aureus. It has broader anaerobic coverage than most cephalosporins, but has virtually no activity against aerobic Gram-negative bacteria[3, 4]. With its excellent activity against both Gram-positive cocci and Gram-positive or-negative anaerobes, clindamycin has a role in the treatment of head and neck, respiratory, bone and soft tissue, abdominal, and pelvic infections[1-5].

Figure 1 The chemical structure of the clindamycin hydrochloride


When given orally, clindamycin is well absorbed and peak concentrations are found after about 45 min. It is metabolized into three major, biologically active derivatives and is mainly excreted into the bile, with about 20% excreted by the kidneys[6]. The normal elimination half-life of about 2 to 4 h is not altered in patients with severe renal disease, but impaired liver function leads to a prolongation of elimination[7].
Clindamycin is purportedly well absorbed(90%) from the gastrointestinal tract, and high concentrations are achieved in most tissues including neutrophils, bone(60%) and joints
[85%] but not in the central nervous system. Recent data indicate that the true absorption of clindamycin may be closer to 50%, and, paradoxically, higher levels are obtained in patients with advanced human immunodeficiency virus(HIV) infection[75% absorption], possibly as a result of decreased hepatic metabolism[8]. Previous studies indicating high absorption may have been measuring an inactive metabolite. The drug is metabolized and excreted by the liver, and dose modifications are recommended for hepatic failure or concomitant renal and hepatic dysfunction. The half-life is 2 to 2.5 h, but may be prolonged to 8 to 12 h in patients with severe liver disease[2]. Biliary excretion of active drug and metabolites results in prolonged activity of clindamycin within the intestine, with effects on gastrointestinal flora for up to two weeks. This may be relevant to both the development and duration of Clostridium difficile-associated colitis. Clindamycin is available as oral tablets(150 and 300 mg), parenteral injection(intramuscular or intravenous), and topical and vaginal formulations. Usual parenteral doses are 600 mg every 6 to 8 h to 900 mg every 8 h. Typical oral doses are 150 to 450 mg qid. Topical formulations include a 2% ointment and 2% vaginal gel.


Clindamycin hydrochloride is used for the treatment of serious infections caused by susceptible anaerobic bacteria, including Peptostreptococcus, anaerobic streptococci, Clostridium, Bacteroides spp., spp., and microaerophilic streptococci[9]. It may be useful in the treatment of polymicrobic infections such as intra-abdominal or pelvic infections, osteomyelitis, diabetic foot ulcers, aspiration pneumonia and dental infections. It is also used for treat MSSA and respiratory infections caused by S. pneumoniae and S. pyogenes in patients who are faced with drug resistance or are intolerant to many other antibiotics. It may also be used vaginally to treat vaginosis caused by Gardnerella vaginosa[9]. Given clindamycin reduces the toxin producing effects of S. aureus and S. pyogenes and as such, it may be particularly useful for treating necrotizing fasciitis. It is also administrated topically to treat acne[9,10].
Furthermore, it is active against organisms such as Plasmodium, Toxoplasma, Babesia, and Pneumocystis spp. Clindamycin is the drug of choice for prophylaxis of Toxoplasma chorioretinitis in newborn infants[11] and is part of recommended regimens against both Babesia microti and Babesia divergens[12]. In combination with pyrimethamine or primaquine, it is an alternative regimen for the treatment of toxoplasmosis and pneumocystosis, respectively[11, 13]. Clinical trials from the 1970s and 1980s have shown the efficacy, safety, and practicability of the treatment of Plasmodium falciparum malaria with clindamycin[14-16].

Mode of action

Clindamycin acts by inhibiting bacterial protein synthesis through binding to the 23S rRNA of 50S ribosome[9, 10]. As a result, it exerts a prolonged post-antibiotic effect. It may decrease toxin production and increase microbial opsonization and phagocytosis even at sub-inhibitory concentrations. Although chemically dissimilar to erythromycin and the macrolide antibiotics, in vitro antagonism occurs as a result of a similar site of binding and mechanism of action. In addition, topical clindamycin can reduce the free fatty acid concentrations on the skin and further suppresses the growth of Propionibacterium acnes[Corynebacterium acnes], an anaerobe found in sebaceous glands and follicles[9, 10].

Adverse reactions

Adverse effects associated with the clindamycin hydrochloride may include nausea[may be dose-limiting], diarrhea, pseudomembranous colitis, allergic reactions, hepatoxicity, transient neutropenia and eosinophilia and agranulocytosis. Pseudomembranous colitis occurs at a ratio of 0.01 10% of patients and occurs more commonly than with other antibiotics. Use of the topical formulation of clindamycin results in absorption of the antibiotic from the skin surface. Diarrhea, bloody diarrhea, and colitis[including pseudomembranous colitis] have been reported with the use of topical and systemic clindamycin[9]. The application of clindamycin can also cause resistant-clostridium difficile colitis. Hypersensitivity reactions include mild to moderate morbilliform-like[maculopapular] skin rashes are the most frequently reported adverse reactions[10]. Vesiculobullous rashes, as well as urticaria, have been observed during drug therapy. Some skin reactions such as Toxic Epidermal Necrolysis, some with fatal outcome, have been reported[10]. Cases of Acute Generalized Exanthematous Pustulosis[AGEP], erythema multiforme, some resembling Stevens-Johnson syndrome, anaphylactic shock, anaphylactic reaction and hypersensitivity have also been reported. For skin and mucous membrane, reactions such as pruritus, angioedema, vaginitis and few cases of exfoliative dermatitis have also been observed. Some liver and renal abnormalities including jaundices, azotemia, oliguria have also been observed[10].

Warning and risk

Special tips should be concerned when administrating clindamycin[17].
People who are allergic to clindamycin or lincomycin should be disabled for using it.
The patients should tell his/her doctor if he/she has the following several cases: colitis, Crohn's disease, or other intestinal disorder; eczema, or allergic skin reaction; liver disease; asthma or a severe allergic reaction to aspirin; an allergy to yellow food dye.
Though it still lacks of information regarding whether clindamycin will harm an unborn baby, you’d better tell your doctor if you are pregnant or plan to become pregnant during treatment. It may not be safe to breast-feed a baby while you are using clindamycin. Ask your doctor about any risks.
Clindamycin injection may contain an ingredient that can cause serious side effects or death in very young or premature babies. Do not give this medicine to a child without medical advice. Call your doctor for help if you get some adverse reactions.


  1. Steigbigel NH. Macrolides and clindamycin. In: Mandell GL, Bennett JE, Dolin R, eds. Douglas and Bennett’s Principles and Practice of Infectious Diseases. New York: Churchill Livingstone, 1995:334-6.
  2. O’Hanley PD, Tam JY, Holodniy M. Infectious disorders. In: Melmon KL, Morrelli HF, Hoffman BB, Nierenberg DW, eds. Melmon and Morrelli’s Clinical Pharmacology: Basic Principles in Therapeutics, 3rd edn. New York: McGraw-Hill, 1992:710.
  3. Falagas ME, Gorbach SL. Clindamycin and metronidazole. Med Clin North Am 1995;79:845-67.
  4. Klainer AS. Clindamycin. Med Clin North Am 1987;71:1169-75.
  5. Dhawan, V. K., & Thadepalli, H.[1982]. Clindamycin: a review of fifteen years of experience. Reviews of Infectious Diseases, 4[6], 1133-1153.
  6. Wagner, J. G., E. Novak, N. C. Patel, C. G. Chidester, and W. Lummis. 1968. Absorption, excretion and half-life of clindamycin in normal adult males. Am. J. Med. Sci. 256:25–37.
  7. Dhawan, V. K., and H. Thadepalli. 1982. Clindamycin: a review of fifteen years of experience. Rev. Infect. Dis. 4:1133–1153.
  8. Gatti G, Flaherty J, Bubp J, White J, Borin M, Gambertoglio J. Comparative study of bioavailabilities and pharmacokinetics of clindamycin in healthy volunteers and patients with AIDS. Antimicrob Agent Chemother 1993; 37:1137-43.
  11. St. Georgiev, V. 1994. Management of toxoplasmosis. Drugs 48:179–188.
  12. Homer, M. J., I. Aguilar-Delfin, S. R. Telford, P. K. Krause, and D. H. Persing. 2000. Babesiosis. Clin. Microbiol. Rev. 13:451–469.
  13. Fishman, J. A. 1998. Treatment of infection due to Pneumocystis carinii. Antimicrob. Agents Chemother. 42:1309–1314.
  14. El Wakeel, E. S., Homeida, M. M., Ali, H. M., Geary, T. G., & Jensen, J. B.[1985]. Clindamycin for the treatment of falciparum malaria in sudan. American Journal of Tropical Medicine & Hygiene, 34[6], 1065.
  15. Kremsner, P. G., Zotter, G. M., Feldmeier, H., Graninger, W., Westerman, R. L., & Rocha, R. M.[1989]. Clindamycin treatment of falciparum malaria in brazil. Journal of Antimicrobial Chemotherapy, 23[2], 275-81.
  16. Clyde, D. F., Gilman, R. H., & Mccarthy, V. C.[1975]. Antimalarial effects of clindamycin in man. American Journal of Tropical Medicine & Hygiene, 24[2], 369-70.

Chemical Properties

White Solid


antibacterial, inhibits protein synthesis


Clindamycin hydrochloride is a salt of clindamycin, a semi-synthetic lincosamide. The hydrochloride salt forms at the basic N-ethylproline moiety and is the preferred pharmaceutical formulation. Like other members of the lincosamide family, clindamycin is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Clindamycin hydrochloride acts by binding to the 23S ribosomal subunit, blocking protein synthesis. Clindamycin hydrochloride has been extensively studied with over 8,000 literature citations.


Labelled Clindamycin. Semi-synthetic antibiotic prepared from Lincomycin;Labeled Clindamycin, intended for use as an internal standard for the quantification of Clindamycin by GC- or LC-mass spectrometry.

brand name

Cleocin (Pharmacia & Upjohn).

Contact allergens

This lincosanide antibiotic is used in topical form for acne, or systemically has been responsible for exanthematous rashes and acute generalized exanthematous pustulosis.

Clinical Use

Clindamycin is recommended for the treatment of a widevariety of upper respiratory, skin, and tissue infections causedby susceptible bacteria. Its activity against streptococci,staphylococci, and pneumococci is indisputably high, and it isone of the most potent agents available against somenon–spore-forming anaerobic bacteria, the Bacteroides particular. An increasing number of reports of clindamycin-associated GI toxicity, which range in severity fromdiarrhea to an occasionally serious pseudomembranous colitis,have, however, caused some clinical experts to call for areappraisal of the role of this antibiotic in therapy.Clindamycin- (or lincomycin)-associated colitis may be particularlydangerous in elderly or debilitated patients and hascaused deaths in such individuals. The colitis, which is usuallyreversible when the drug is discontinued, is now believedto result from an overgrowth of a clindamycin-resistant strainof the anaerobic intestinal bacterium Clostridium difficile.229The intestinal lining is damaged by a glycoprotein endotoxinreleased by lysis of this organism.
The glycopeptide antibiotic vancomycin has been effectivein the treatment of clindamycin-induced pseudomembranouscolitis and in the control of the experimentally induced bacterial condition in animals. Clindamycin shouldbe reserved for staphylococcal tissue infections, such as cellulitisand osteomyelitis, in penicillin-allergic patients andfor severe anaerobic infections outside the central nervoussystem. Ordinarily, it should not be used to treat upper respiratorytract infections caused by bacteria sensitive to othersafer antibiotics or in prophylaxis.

Veterinary Drugs and Treatments

Clindamycin products are approved for use in dogs and cats. The labeled indications for dogs include wounds, abscesses and osteomyelitis caused by Staphylococcus aureus. Because clindamycin has excellent activity against most pathogenic anaerobic organisms, it is also used extensively for those infections. Clindamycin is used for a variety of protozoal infections, including toxoplasmosis. For further information, refer to the Dosage or Pharmacology sections.

Clindamycin hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Clindamycin hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-04-12 Clindamycin Hydrochloride
US $1.00 / g 10g 99% 1000 Kilogram/Kilograms per Month Cangzhou Wanyou New Material Technology Co.,Ltd
2018-07-26 Clindamycin hydrochloride
US $100.00 / KG 1KG 99% Customized career henan chemical co
2018-04-11 Clindamycin hydrochloride
US $100.00-10.00 / G 1KG 99% 10mt Hubei XinRunde Chemical Co., Ltd.

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