Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Raloxifene hydrochloride

Raloxifene hydrochloride

Raloxifene hydrochloride Structure
Raloxifene hydrochloride structure
CAS No.
82640-04-8
Chemical Name:
Raloxifene hydrochloride
Synonyms
CS-127;ly156758;KEOXIFENE;LY 139481;AKOS 92138;RALOXIFENE HCL;LY156758 hydrochloride;LY139481 hydrochloride;Latilavir secondary VI;Evista (Raloxifene HCl)
CBNumber:
CB6302366
Molecular Formula:
C28H28ClNO4S
Molecular Weight:
510.04
MDL Number:
MFCD01938233
MOL File:
82640-04-8.mol
Last updated:2024-04-28 19:50:54
Request For Quotation

Raloxifene hydrochloride Properties

Melting point 250-253°C
storage temp. 2-8°C
solubility DMSO: 28 mg/mL, soluble
form solid
color light yellow
λmax 286nm(lit.)
Merck 14,8098
BCS Class 2
InChIKey BKXVVCILCIUCLG-UHFFFAOYSA-N
SMILES C1(C(=O)C2C=CC(OCCN3CCCCC3)=CC=2)C2C=CC(O)=CC=2SC=1C1C=CC(O)=CC=1.Cl
CAS DataBase Reference 82640-04-8(CAS DataBase Reference)
FDA UNII 4F86W47BR6
NCI Dictionary of Cancer Terms raloxifene hydrochloride
NCI Drug Dictionary raloxifene hydrochloride

Pharmacokinetic data

Protein binding 98-99%
Excreted unchanged in urine <0.2%
Volume of distribution 2348(L/kg)
Biological half-life 27.7 / Unchanged

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Warning
Hazard statements  H351-H361d
Precautionary statements  P201-P202-P280-P308+P313-P405-P501
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  22-24/25
WGK Germany  3
RTECS  PC4956925
HS Code  2934990002

Raloxifene hydrochloride price More Price(40)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR1852 Raloxifene hydrochloride for peak identification Pharmaceutical Secondary Standard; Certified Reference Material 82640-04-8 500mg $173 2024-03-01 Buy
Sigma-Aldrich 1598201 Raloxifene hydrochloride 82640-04-8 200mg $436 2024-03-01 Buy
Cayman Chemical 27189 Raloxifene (hydrochloride) ≥98% 82640-04-8 50mg $648 2024-03-01 Buy
Cayman Chemical 10011620 Raloxifene (hydrochloride) ≥98% 82640-04-8 50mg $32 2024-03-01 Buy
Cayman Chemical 10011620 Raloxifene (hydrochloride) ≥98% 82640-04-8 100mg $61 2024-03-01 Buy
Product number Packaging Price Buy
PHR1852 500mg $173 Buy
1598201 200mg $436 Buy
27189 50mg $648 Buy
10011620 50mg $32 Buy
10011620 100mg $61 Buy

Raloxifene hydrochloride Chemical Properties,Uses,Production

Description

Raloxifene was launched as Evista in the US for the prevention of postmenopausal osteoporosis. It is noteworthy that this molecule was formerly under development as keoxifene for breast cancer and prostatic hypertrophy. Raloxifene can be prepared by acylation of 6-methoxy-2-(4-methoxyphenyl) benzothiophene followed by simultaneous demethylation of both methoxy groups. Raloxifen is a selective estrogen receptor modulator, exerting antiestrogenic action on certain tissues (breast) and also estrogenic action on bone metabolism or serum lipids. In normal early postmenopausal women, 200 mg daily produced a trend towards suppression of estrogen effects. Raloxifen impeded bone loss in osteoporosis. A two-year study in postmenopausal women with an increased risk for osteoporosis showed that Raloxifen markedly prevented non-traumatic vertebral fractures. Results of several clinical studies demonstrated that Raloxifen appreciably reduced the risk of developing breast cancer. Moreover, it had favourable effect on lipid profiles without having the potential side-effects of estrogen-based therapies. Several extensions for different uses of this molecule are planned, for example growth disorder, obesity, colon tumor and skin atrophy. No serious drug-related events have been reported in the limited number of clinical trials.

Chemical Properties

Light-Yellow Solid

Originator

Lilly (US)

Uses

Labeled Raloxifene, intended for use as an internal standard for the quantification of Raloxifene by GC- or LC-mass spectrometry.

Uses

amino acid, nutrient. A nonsteroidal, selective estrogen receptor modulator (SERM). Antiosteoporotic.Insoluble in water.

Uses

Raloxifene hydrochloride can be used as a nonsteroidal, selective estrogen receptor modulator (SERM). Antiosteoporotic.

Definition

ChEBI: A hydrochloride salt resulting from the reaction of equimolar amounts of raloxifene and hydrogen chloride.

brand name

Evista (Lilly).

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Biochem/physiol Actions

Raloxifene is a selective estrogen receptor modulator (SERM); acts as an anti-estrogen in both breast and uterine tissue while being estrogenic in bone. May have efficacy against estrogen-sensitive cancers.

Clinical Use

Treatment and prevention of osteoporosis in post menopausal women

Drug interactions

Potentially hazardous interactions with other drugs
Anticoagulants: antagonism of anticoagulant effect of coumarins.
Colestyramine: reduced absorption of raloxifene - avoid.

Metabolism

Raloxifene undergoes extensive first pass metabolism to the glucuronide conjugates: raloxifene-4'- glucuronide, raloxifene-6-glucuronide, and raloxifene-6, 4′-diglucuronide.
Raloxifene undergoes enterohepatic recycling, and is excreted almost entirely in the faeces. Less than 6% of dose is excreted in the urine.

storage

+4°C (desiccate)

References

[1] obach rs.potent inhibition of human liver aldehyde oxidase by raloxifene.

Raloxifene hydrochloride synthesis

84541-36-6
82640-04-8
Synthesis of Raloxifene hydrochloride from 6-METHOXY-2-(4-METHOXY PHENYL)-BENZO[B]THIEN-3-YL][4-[2-(1-[PIPERIDINYL)ETHOXY]PHENYL]METHANONE HYDROCHLORIDE

Raloxifene hydrochloride Preparation Products And Raw materials

Raw materials

(4-(2-(PIPERIDIN-1-YL)ETHOXY)PHENYL)(6-METHOXY-2-(4-METHOXYPHENYL)BENZO[B]THIOPHEN-3-YL)METHANONE 6-METHOXY-2-(4-METHOXY PHENYL)-BENZO[B]THIEN-3-YL][4-[2-(1-[PIPERIDINYL)ETHOXY]PHENYL]METHANONE HYDROCHLORIDE

Preparation Products

Raloxifene

Raloxifene hydrochloride Suppliers

Global( 474)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Worldyang Chemical Co.,Ltd.
,+86-21-56795779; +8613651600618 sales@worldyachem.com China 879 58
Baoji Guokang Bio-Technology Co., Ltd.
0917-3909592 13892490616 gksales1@gk-bio.com China 9331 58
Wuhan Godbullraw Chemical Co.,ltd
+undefined18986288449 Alisasales@godbullraw.com China 560 58
Anhui Zhongda Biotechnology Co., Ltd
+8619956560829 justine@zhongda-biotech.com China 300 58
Hong Kong Excellence Biotechnology Co., Ltd. 		+86-86-18838029171 +8618126314766 ada@sh-teruiop.com China 893 58
Anhui Ruihan Technology Co., Ltd 		+8617756083858 daisy@anhuiruihan.com China 994 58
zhuzhou dingcheng meihei comestic co.,ltd 		+8618873369619 dingchengbusiness8@163.com China 242 58
Sigma Audley 		+86-18336680971 +86-18126314766 nova@sh-teruiop.com China 525 58
Shanghai Aosiris new Material Technology Co., LTD 		86-15139564871 +8615139564871 wrjmoon2000@163.com China 357 58
Shanghai Getian Industrial Co., LTD 		+86-15373193816 +86-15373193816 mike@ge-tian.com China 274 58
Supplier Advantage
Shanghai Worldyang Chemical Co.,Ltd.
58
Baoji Guokang Bio-Technology Co., Ltd.
58
Wuhan Godbullraw Chemical Co.,ltd
58
Anhui Zhongda Biotechnology Co., Ltd
58
Hong Kong Excellence Biotechnology Co., Ltd. 		58
Anhui Ruihan Technology Co., Ltd 		58
zhuzhou dingcheng meihei comestic co.,ltd 		58
Sigma Audley 		58
Shanghai Aosiris new Material Technology Co., LTD 		58
Shanghai Getian Industrial Co., LTD 		58

Related articles

View Lastest Price from Raloxifene hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Raloxifene hydrochloride pictures 2024-05-15 Raloxifene hydrochloride
82640-04-8
 US $26.00 / box 1box 99% 100000box Shanghai Getian Industrial Co., LTD
Raloxifene Hydrochloride / Keoxifene / Evista pictures 2024-04-29 Raloxifene Hydrochloride / Keoxifene / Evista
82640-04-8
 US $40.00 / Box 1Box 99.99% 10000000000 zhuzhou dingcheng meihei comestic co.,ltd
Raloxifene hcl pictures 2024-04-25 Raloxifene hcl
82640-04-8
 US $100.00 / kg 1kg 99.9% 20tons Hong Kong Excellence Biotechnology Co., Ltd.
  • Raloxifene hcl pictures
  • Raloxifene hcl
    82640-04-8
  • US $100.00 / kg
  • 99.9%
  • Hong Kong Excellence Biotechnology Co., Ltd.

Raloxifene hydrochloride Spectrum

Raloxifene hydrochloride(82640-04-8)1HNMR

82640-04-8(Raloxifene hydrochloride)Related Search:

Diethoxymethyl acetate 2-Ethoxyphenol Benzo[b]thien-2-ylboronic acid Ethoxyquin Topotecan hydrochloride
Phenetidine 1-AdaMantanethylaMine DIETHOXYMETHANE acetic acid, triethoxy-, ethyl ester CHLOROPHOSPHONAZO III
Raloxifene 4-Ethoxyphenol Droloxifene Ranitidine hydrochloride Lercanidipine hydrochloride
Clindamycin hydrochloride Tramadol hydrochloride Sibutramine hydrochloride

1of4

RALOXIFENE HCL Raloxifene hydrochloride,Keoxifene hydrochloride, LY 156758, [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone hydrochloride Raloxifene Hydrochloride (200 mg) 2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethoxy]phenyl}carbonyl)-1-benzothiophen-6-ol hydrochloride (6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)(4-(2-(piperidin-1-yl)ethoxy)phenyl)Methanone hydrochloride Evista(Raloxifene Hydrochloride (6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)-(4-(2-(piperidin-1-yl)ethoxy)phenyl)methanon [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-methanone,hydrochloride (1:1) LY156758 (Keoxifene) HCl Evista (Raloxifene HCl) Methanone,[6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-,hydrochloride (1:1) (6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)-(4-(2-(piperidin-1-yl)ethoxy)phenyl)metha RALOXIFENE HYDROCHLORIDE KEOXIFENE KEOXIFENE HYDROCHLORIDE LY 139481 AKOS 92138 ly156758 methanone,(6-hydroxy-2-(4-hydroxyphenyl)benzo(b)thien-3-yl)(4-(2-(1-piperidin [6-HYDROXY-2-(4-HYDROXYPHENYL)BENZO[B]THIEN-3-YL][4-[2-(1-PIPERIDINYL)ETHOXY]PHENYL]-METHANONE HYDROCHLORIDE [6-Hydroxy-2-(4-Hydroxyphenyl) benzo[b]thien-3-yl] RALOXIFENEHYDROCHLORIDE(SUBJECTTOPATENTFREE) Keoxifene hydrochloride, LY 156758, [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone hydrochloride 6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl) ethoxy]phenyl]methanone HCl Raloxifene Hydrochloride Tablets LY156758 hydrochloride CS-127 LY139481 hydrochloride Raloxifene hydrochloride,>98% [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone Hydrochloride Raloxifene hydrochloride USP/EP/BP Latilavir secondary VI Raloxifene hydrochloride Evista [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone Raloxefene hydrochloride Raloxifene HCl (LY-139481) Raloxifene hydrochloride (Y0001134) Raloxifene Hydrochloride (1598201) (1aΞ,7aΞ)-1a-methyl-7a-[(2E,7RS,11RS)-3,7,11,15-tetramethylhexadec-2-en-1-yl]-1a,7a-dihydronaphtho[2,3-b]oxirene-2,7-dione (trans-epoxyphytomenadione isomers) 82640-04-8 28640-04-8 C28H27NO4S.HCl C28H27NO4SClH C28H27NO4SHClC28H28ClNO4S API Pharmaceutical intermediate Inhibitors antifungal Aromatics Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds Active Pharmaceutical Ingredients Raloxifene Intracellular receptor