1-Methylpiperidine-4-carboxylic acid hydrochloride
- CAS No.
- 71985-80-3
- Chemical Name:
- 1-Methylpiperidine-4-carboxylic acid hydrochloride
- Synonyms
- BIO-FARMA BF002150;RARECHEM AH CK 0139;TIMTEC-BB SBB003751;Lasmiditan Impurity 45;N-MethylisonipecoticacidHCl;4-CARBOXY-1-METHYL-PIPERIDINE HCL;1-Methyl-piperidine-4-carboxylic a;Methylpiperidincarbonsurehydrochlorid;1-Methyl-4-piperidinecarboxylic acid HCl;1-METHYL-PIPERIDINE-4-CARBOXYLIC ACID HCL
- CBNumber:
- CB6341912
- Molecular Formula:
- C7H14ClNO2
- Molecular Weight:
- 179.64
- MDL Number:
- MFCD00190235
- MOL File:
- 71985-80-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 1-Methylpiperidine-4-carboxylic acid hydrochloride | M320978 | 500mg | $75 |
| 1-Methylpiperidine-4-carboxylic acid hydrochloride | Y9343 | 25g | $82 |
| 1-Methylpiperidine-4-carboxylic acid hydrochloride 98% | JK118455 | 5g | $100 |
| 1-Methylpiperidine-4-carboxylic acidhydrochloride | 016314 | 1g | $10 |
| 1-Methylpiperidine-4-carboxylic acid hydrochloride 98% | 4H21-5-Z0 | 1g | $21 |
| More product size | |||
| Melting point | 226-228°C (dec.) |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| form | solid |
| color | Off-white |
| InChI | InChI=1S/C7H13NO2.ClH/c1-8-4-2-6(3-5-8)7(9)10;/h6H,2-5H2,1H3,(H,9,10);1H |
| InChIKey | NLUDEWJJEMHIIL-UHFFFAOYSA-N |
| SMILES | N1(C)CCC(C(O)=O)CC1.[H]Cl |
| CAS DataBase Reference | 71985-80-3(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38-20/21/22 |
| Safety Statements | 26-36-24/25-36/37 |
| HazardClass | IRRITANT |
| HS Code | 29339900 |
1-Methylpiperidine-4-carboxylic acid hydrochloride price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | M320978 | 1-Methylpiperidine-4-carboxylic acid hydrochloride | 71985-80-3 | 500mg | $75 | 2021-12-16 | Buy |
| AK Scientific | Y9343 | 1-Methylpiperidine-4-carboxylic acid hydrochloride | 71985-80-3 | 25g | $82 | 2021-12-16 | Buy |
| Frontier Specialty Chemicals | JK118455 | 1-Methylpiperidine-4-carboxylic acid hydrochloride 98% | 71985-80-3 | 5g | $100 | 2021-12-16 | Buy |
| Matrix Scientific | 016314 | 1-Methylpiperidine-4-carboxylic acidhydrochloride | 71985-80-3 | 1g | $10 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H21-5-Z0 | 1-Methylpiperidine-4-carboxylic acid hydrochloride 98% | 71985-80-3 | 1g | $21 | 2021-12-16 | Buy |
1-Methylpiperidine-4-carboxylic acid hydrochloride Chemical Properties,Uses,Production
Chemical Properties
Off-white solid
Synthesis
The synthesis method of 1-Methylpiperidine-4-carboxylic acid Hydrochloride is shown below: Charge isonipecotic acid, palladium, and purified water into a reaction vessel. Heat the resulting mixture to 90 to 95° C. Charge formic acid and formaldehyde to the vessel. Cool the resulting mixture to 20 to 30° C. Filter the reaction mixture through GF/F. Wash the filter cake with purified water. Concentrate the combined filtrates to ca 2 vol at atmospheric pressure. Adjust the temperature 65 to 75° C. Charge conc—hydrochloric acid to the vessel. Charge acetonitrile to the vessel at ≧70° C. and concentrate the solution to ca 2 vol at atmospheric pressure. Charge acetonitrile to the vessel. Moreover, concentrate the solution at atmospheric pressure to ca 2 vol. Charge acetonitrile to the vessel. Moreover, concentrate the solution at atmospheric pressure to ca 3 vol. Check the water content by KF analysis of the supernatant liquors using AX reagent. Cool the reaction mixture to 20 to 25° C. Stir the reaction mixture for 1 to 2 hours. Filter the reaction mixture. Wash the filter cake with acetonitrile. Dry the product up to 50° C. until ≦0.5% w/w by LOD and ≦0.2% w/w water.
References
[1] Journal of Medicinal Chemistry, 1988, vol. 31, # 4, p. 807 - 814
[2] Patent: WO2011/123654, 2011, A1. Location in patent: Page/Page column 29-30
[3] Patent: WO2010/83384, 2010, A2. Location in patent: Page/Page column 61
1-Methylpiperidine-4-carboxylic acid hydrochloride Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou Nordica Biopharma CO.,LTD | +86-18136148818 +86-18567353071 | 3537297702@qq.com | China | 299 | 58 |
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 16514 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Chembon Pharmaceutical Co., Ltd. | +86-28-8425-2981 | CHINA | 722 | 55 | |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88299272 | info@edengenechem.com | China | 2176 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
View Lastest Price from 1-Methylpiperidine-4-carboxylic acid hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-10-13 | 1-METHYLPIPERIDINE-4-CARBOXYLIC ACID HYDROCHLORIDE
71985-80-3
|
US $2.20-8.80 / kg | 1kg | 99% | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2025-07-08 | 1-METHYLPIPERIDINE-4-CARBOXYLIC ACID HYDROCHLORIDE
71985-80-3
|
US $0.00 / kg | 1kg | 99.0%min | 10000kg | Hangzhou ICH Biofarm Co., Ltd | |
 |
2020-01-10 | 1-METHYLPIPERIDINE-4-CARBOXYLIC ACID HYDROCHLORIDE
71985-80-3
|
US $1.00 / KG | 1KG | ≥98% | 20 tons | Career Henan Chemical Co |
-
- 1-METHYLPIPERIDINE-4-CARBOXYLIC ACID HYDROCHLORIDE
71985-80-3
- US $2.20-8.80 / kg
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 1-METHYLPIPERIDINE-4-CARBOXYLIC ACID HYDROCHLORIDE
71985-80-3
- US $0.00 / kg
- 99.0%min
- Hangzhou ICH Biofarm Co., Ltd
-
- 1-METHYLPIPERIDINE-4-CARBOXYLIC ACID HYDROCHLORIDE
71985-80-3
- US $1.00 / KG
- ≥98%
- Career Henan Chemical Co
