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Fluocinolone acetonide

Corticosteroid drug Physical and Chemical Properties Fluocinolone acetonide Uses
Fluocinolone acetonide
Fluocinolone acetonide structure
CAS No.
67-73-2
Chemical Name:
Fluocinolone acetonide
Synonyms
jellin;synsac;Fluzon;localyn;synalar;synamol;SINALAR;Fluonid;dermalar;radiocin
CBNumber:
CB6394372
Molecular Formula:
C24H30F2O6
Formula Weight:
452.49
MOL File:
67-73-2.mol

Fluocinolone acetonide Properties

Melting point:
267-269 °C(lit.)
alpha 
D +95° (chloroform)
Density 
1.1826 (estimate)
refractive index 
103 ° (C=1, MeOH)
storage temp. 
Refrigerator
solubility 
Practically insoluble in water, soluble in acetone and in ethanol
form 
neat
Water Solubility 
Soluble in water (partly), DMSO, alcohol, chloroform and methanol.
Merck 
14,4150
CAS DataBase Reference
67-73-2(CAS DataBase Reference)
EPA Substance Registry System
Pregna-1,4-diene- 3,20-dione, 6,9-difluoro-11,21-dihydroxy- 16,17-[(1-methylethylidene) bis(oxy)]-, (6.alpha.,11.beta.,16.alpha.)- (67-73-2)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-40-20/21/22
Safety Statements  26-36-22
WGK Germany  3
RTECS  TU3830000
Hazardous Substances Data 67-73-2(Hazardous Substances Data)
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Fluocinolone acetonide price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1275009 Fluocinolone acetonide United States Pharmacopeia (USP) Reference Standard 67-73-2 100mg $348 2018-11-20 Buy
Sigma-Aldrich F8880 Fluocinolone acetonide analytical standard 67-73-2 1g $402 2018-11-20 Buy
Alfa Aesar J63996 Fluocinolone acetonide 67-73-2 100mg $47.6 2018-11-13 Buy
Alfa Aesar J63996 Fluocinolone acetonide 67-73-2 1g $261 2018-11-13 Buy
Cayman Chemical 23027 Fluocinolone acetonide ≥98% 67-73-2 1g $188 2018-11-19 Buy

Fluocinolone acetonide Chemical Properties,Uses,Production

Corticosteroid drug

Fluocinolone acetonide is a kind of topical corticosteroids of the most significant effect and the least side effect in current china, and can cause the contraction of dermal capillary, inhibit cell proliferation or regeneration of connective tissue; it can also stabilize the intracellular lysosomal membrane and prevent the release of histamine from the intracellular lysosomal enzyme and the further tissue damage. The anti-inflammatory effects of Fluocinolone is 100 times as great s that of hydrocortisone. It has significant efficacy even at the lowest concentration (0.025%) with rapid onset rate and can significantly reduce or cure the symptoms in a few days with a relative excellent itching relief effect. Fluocinolone acetonide is mainly used for the treatment of skin diseases to which glucocorticoid is effective such as contact dermatitis, atopic dermatitis, seborrheic dermatitis, neurodermatitis, dermatitis, eczema (especially infant eczema), pruritus disease, psoriasis, discoid lupus erythematosus, lichen planus, otitis externa and so on. Its combination with neomycin and other antibiotics can be used for the treatment of suppurative skin disease. Apply 0.025-0.05% ointment, lotion for scrubbing the affected area with 2-3 times per day. You can gently knead and make it be incorporated into the skin.

Physical and Chemical Properties

It appears as white or white-like crystalline powder and is odorless and tasteless. [α] D20+80-+88° (dioxane). It is soluble in acetone, slightly soluble in ethanol, dioxane but insoluble in water and petroleum ether. It is obtained through the sulfonic esterfication, ring-opening reaction and further 16-steps reactions starting from the 11α-hydroxy-16α, 17α-epoxy pregnane-4-ene-3, 20-dione. It can be applied to atopic dermatitis, contact dermatitis, eczema and other skin diseases.

Fluocinolone acetonide

Fluocinolone acetonide is a synthetic, fluorine-containing potent steroid. Topical administration of it can cause dermal capillary contraction and can inhibit epidermal cell proliferation or regeneration, inhibit the newborn of the fibroblast cells inside the connective tissue and stabilize the intracellular lysosomal membrane with anti-inflammatory and anti-itching effect. After topical administration, it can be absorbed through intact skin. After its absorption, similar as the metabolism of corticosteroid after systemic administration, it is mainly metabolized in the liver and can be excreted by the kidneys. Fluocinolone acetonide is suitable for treating the skin disease to which corticosteroid is effective skin such as eczema (especially eczema), neurodermatitis, skin pruritus, contact dermatitis, psoriasis, discoid lupus erythematosus, lichen planus, otitis externa, and solar dermatitis. However, it should be note that long-term or large-scale application can cause skin atrophy, telangiectasia and the occurrence of acne-like dermatitis, perioral dermatitis, folliculitis, and increased susceptibility to infection and so on. Allergic contact dermatitis can also occur in some cases.
This information is edited by Xiongfeng Dai from Chemicalbook.

Uses

It is suitable in the treatment of eczema, neurodermatitis, skin pruritus, contact dermatitis, psoriasis, dermatitis and other diseases

Chemical Properties

Crystalline Solid

Uses

A synthetic glucocorticoid VEGF inhibitor.

Uses

Glucocorticoid; anti-inflammatory

Definition

ChEBI: A fluorinated steroid that is flunisolide in which the hydrogen at position 9 is replaced by fluorine. A corticosteroid with glucocorticoid activity, it is used (both as the anhydrous form and as the dihydrate) in creams, gels and ointments for the treatme t of various skin disorders.

brand name

Fluonid (Allergan); Fluotrex (Savage); FS Shampoo (Galderma); Retisert (Bausch & Lomb); Synalar (Medicis).

General Description

Fluocinolone acetonide,6α,9-difluoro-11β,21-dihydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione, also known as6α-fluorotriamcinolone acetonide, is the 21-acetate derivativeof fluocinolone acetonide and is about 5 times morepotent than fluocinolone acetonide in at least one topicalactivity assay.

Fluocinolone acetonide Preparation Products And Raw materials

Raw materials

Preparation Products


Fluocinolone acetonide Suppliers

Global( 209)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3217 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22043 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Mainchem Co., Ltd.
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+86-0592-6210733 sales@mainchem.com CHINA 32651 55
Hubei XinRunde Chemical Co., Ltd.
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02783214688 bruce@xrdchem.cn CHINA 552 55
Hubei Jusheng Technology Co.,Ltd.
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Accela ChemBio Inc.
(+1)-858-699-3322
(+1)-858-876-1948 info@accelachem.com United States 12156 58
Jinan Tenglong Chemical Co.,Ltd
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career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 19997 58
Hubei Yuancheng Saichuang Technology Co., Ltd. 18062666868/13048470578 QQ2355779403/2355880551
023-60363599,027-68886696 andy@ycgmp.com,2355880551@qq.com,2355779403@qq.com China 5081 58

View Lastest Price from Fluocinolone acetonide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-18 Fluocinolone acetonide
67-73-2
US $1.00 / kg 1kg 95%-99% 10kg career henan chemical co
2018-03-09 Fluocinolone acetonide
67-73-2
US $100.00 / KG 10G 99.9% 100kg/week Hubei XinRunde Chemical Co., Ltd.

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