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Triamcinolone acetonide

Appearance and properties Glucocorticoid drugs Uses Category Toxicity grading Acute toxicity Flammability hazard characteristics Storage Characteristics Extinguishing agent
Triamcinolone acetonide
Triamcinolone acetonide structure
CAS No.
76-25-5
Chemical Name:
Triamcinolone acetonide
Synonyms
ERIC1;TAC-3;Triam;Trymex;ERIC-1;TAC-40;RINETON;KENALOG;Coupe-A;Vetalog
CBNumber:
CB4186553
Molecular Formula:
C24H31FO6
Formula Weight:
434.5
MOL File:
76-25-5.mol

Triamcinolone acetonide Properties

Melting point:
274-278°C (dec.)
alpha 
D23 +109° (c = 0.75 in chloroform)
Density 
1.1517 (estimate)
refractive index 
1.5980 (estimate)
storage temp. 
Refrigerator
solubility 
Practically insoluble in water, sparingly soluble in ethanol (96 per cent).
form 
neat
Water Solubility 
Soluble in DMSO or ethanol. Slightly soluble in water.
Merck 
9596
Stability:
Combustible. Incompatible with strong oxidizing agents.
InChIKey
YNDXUCZADRHECN-JNQJZLCISA-N
NIST Chemistry Reference
Triamcinolone acetonide(76-25-5)
EPA Substance Registry System
Pregna-1,4-diene- 3,20-dione, 9-fluoro-11,21-dihydroxy-16, 17-[(1-methylethylidene)bis( oxy)]-, (11.beta.,16.alpha.)-(76-25-5)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T
Risk Statements  61
Safety Statements  53-45
WGK Germany  3
RTECS  TU3920000
TSCA  Yes
HS Code  29372290
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger
Precautionary statements:
P201 Obtain special instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.

Triamcinolone acetonide price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR1701 Triamcinolone acetonide Pharmaceutical Secondary Standard; Certified Reference Material 76-25-5 1g $110 2018-11-20 Buy
Sigma-Aldrich 1677002 Triamcinolone acetonide United States Pharmacopeia (USP) Reference Standard 76-25-5 500mg $352.8 2018-11-20 Buy
Alfa Aesar J63548 Triamcinolone acetonide, 98+% 76-25-5 1g $108 2018-11-13 Buy
Alfa Aesar J63548 Triamcinolone acetonide 98+% 76-25-5 250mg $40.3 2018-11-20 Buy
Cayman Chemical 18026 Triamcinolone acetonide ≥98% 76-25-5 100mg $25 2018-11-13 Buy

Triamcinolone acetonide Chemical Properties,Uses,Production

Appearance and properties

Triamcinolone acetonide, its acetate form appears to be white or white-like crystalline powder. The drug is odorless, with bitter taste. It is hardly soluble in water, slightly soluble in ethanol, soluble in chloroform, and slightly soluble in acetone.

Glucocorticoid drugs

Triamcinolone acetonide is a kind of long-term glucocorticoid drugs which is now widely used in clinical Dermatology of China. It belongs to adrenocorticotropic hormone drugs. It is the derivative of Triamcinolone, and with the same function as Triamcinolone. Triamcinolone acetonide functions in anti-inflammatory, anti-allergic, anti-itching and shrinking capillaries. What’s more, besides its weak water-sodium retention, the effect of Triamcinolone acetonide for anti-inflammatory, anti-allergic is much stronger and more durable than hydrocortisone (10 to 30 folds), and prednisone. It can also treat bronchial asthma by aerosol inhalation with very strong and durable effect. Triamcinolone acetonide has better efficacy on local treatment compared with triamcinolone. It is Oral absorbed easily. Taking orally 5mg of the drug yields a bioavailability of about 23%. Its plasma concentration reaches peak (105 ng/mL) within one hour with the half-life is being 2 hours; It has a slow intramuscular absorption rate which takes effect within hours, and gives maximal effect within 1 to 2 days. The effect can be maintained for 2~3 weeks; the absorption rate of intradermal and intra-articular injection of the drug is low, but has a long-lasting effect; generally the efficacy can be maintained for more than 1-2 week per injection. This product has a low binding rate with plasma albumin protein, and is metabolized into non-active product in the liver, kidneys and tissues which is then further excreted by the kidneys. It also has a long-lasting effect upon local injection. Moreover, topical ointments can also produce a good effect. Clinically triamcinolone acetonide is used for treatment of various skin diseases such as atopic dermatitis, contact dermatitis, seborrheic dermatitis, neurodermatitis, eczema, psoriasis, psoriasis, lichen planus and skin pruritus, as well as bronchial asthma, rheumatoid arthritis, acute sprains, chronic ache in back and legs, frozen shoulder, tenosynovitis, ophthalmic inflammation, oral mucosal congestion, erosion, ulcers, granulomatous cheilitis, and oral mucosa chronic infectious diseases, Furthermore, it can also be used for local injection treatment in keloid, cystic acne, discoid lupus erythematosus, alopecia areata and other small area of damages. Triamcinolone acetonide nasal spray can be used for the prevention and treatment of perennial, seasonal allergic rhinitis, and vasomotor rhinitis. Intra-articular injection of this drug can eliminate inflammation and pain, swelling or can alleviate, pain, stiffness and swelling feeling.
The above information is edited by the Chemicalbook of Dai Xiongfeng.

Uses

It is adrenal cortex hormones drugs used for treating diseases such as neurodermatitis, eczema, psoriasis, joint pain, and asthma.

Category

Toxic Substances.

Toxicity grading

Highly toxic.

Acute toxicity

Subcutaneous-rat LD50: 13.1 mg/kg; intraperitoneal-Mouse LD50: 105 mg/kg.

Flammability hazard characteristics

Combustible; combustion produces toxic fumes of fluoride.

Storage Characteristics

Treasury: ventilation, low-temperature and dry; store separately from food raw materials.

Extinguishing agent

Dry powder, foam, sand, carbon dioxide, water spray.

Chemical Properties

White Solid

Uses

A glucocorticoid, antiasthmatic (inhalant); antiallergic (nasal).

Uses

antiinflammatory

Definition

ChEBI: A synthetic glucocorticoid that is the 16,17-acetonide of triamcinolone. Used to treat various skin infections.

General Description

The three main metabolitesof triamcinolone acetonide (Azmacort, Nasacort) are 6β-hydroxytriamcinolone acetonide, 21-carboxytriamcinoloneacetonide, and 6β-hydroxy-21-carboxytriamcinolone acetonide.All are much less active than the parent compound.The 6β-hydroxyl group and the 21-carboxy group are bothstructural features that greatly reduce GC action. The increasedwater solubility of these metabolites also facilitatesmore rapid excretion.

General Description

Triamcinolone acetonide is approximately 8 times morepotent than prednisone in animal inflammation models.Topically applied triamcinolone acetonide is a potent antiinflammatoryagent, about 10 times more sothan triamcinolone. The plasma half-life is approximately 90minutes, although the plasma half-life and biological halflivesfor GCs do not correlate well. The hexacetonide isslowly converted to the acetonide in vivo and is given onlyby intra-articular injection. Only triamcinolone and the diacetateare given orally. The acetonide and diacetate may begiven by intra-articular or intrasynovial injection. In addition,the acetonide may be given by intrabursal or, sometimes,IM or subcutaneous injection. A single IM dose of thediacetate or acetonide may last up to 3 or 4 weeks. Plasmalevels with IM doses of the acetonide are significantly higherthan with triamcinolone itself. The acetonide is also used totreat asthma and allergic rhinitis.

Safety Profile

Poison by subcutaneous and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and toxic fumes of F-.

Veterinary Drugs and Treatments

The systemic veterinary labeled product (Vetalog? Injection) is labeled as “indicated for the treatment of inflammation and related disorders in dogs, cats, and horses. It is also indicated for use in dogs and cats for the management and treatment of acute arthritis, allergic and dermatologic disorders.”
Glucocorticoids have been used in an attempt to treat practically every malady that afflicts man or animal, but there are three broad uses and dosage ranges for use of these agents. 1) Replacement of glucocorticoid activity in patients with adrenal insufficiency, 2) as an antiinflammatory agent, and 3) as an immunosuppressive. Among some of the uses for glucocorticoids include treatment of: endocrine conditions (e.g., adrenal insufficiency), rheumatic diseases (e.g., rheumatoid arthritis), collagen diseases (e.g., systemic lupus), allergic states, respiratory diseases (e.g., asthma), dermatologic diseases (e.g., pemphigus, allergic dermatoses), hematologic disorders (e.g., thrombocytopenias, autoimmune hemolytic anemias), neoplasias, nervous system disorders (increased CSF pressure), GI diseases (e.g., ulcerative colitis exacerbations), and renal diseases (e.g., nephrotic syndrome). Some glucocorticoids are used topically in the eye and skin for various conditions or are injected intra-articularly or intra-lesionally. The above listing is certainly not complete.

Triamcinolone acetonide Preparation Products And Raw materials

Raw materials

Preparation Products


Triamcinolone acetonide Suppliers

Global( 280)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3203 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
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Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
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Shanghai Bojing Chemical Co.,Ltd.
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Henan Tianfu Chemical Co.,Ltd.
0371-55170693
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Mainchem Co., Ltd.
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Hubei XinRunde Chemical Co., Ltd.
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Xiamen AmoyChem Co., Ltd
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Shanghai Zheyan Biotech Co., Ltd.
18017610038
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career henan chemical co
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View Lastest Price from Triamcinolone acetonide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-17 Triamcinolone acetonide
76-25-5
US $7.00 / kg 1kg 99% 100KG career henan chemical co
2018-03-09 Triamcinolone acetonide
76-25-5
US $100.00 / KG 10G 99.9% 100kg/week Hubei XinRunde Chemical Co., Ltd.

Triamcinolone acetonide Spectrum


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