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Picotamide

Picotamide structure

CAS No.: 32828-81-2

Chemical Name:: Picotamide

Synonyms: g137;PICOTAMIDE;N,N’-Bis(3-Pyridinylmethyl)-4-Me;n,n’-bis(3-picolyl)-4-methoxyisophthalamide;4-methoxy-n,n’-bis(3-pyridylmethyl)isophthalamide;4-methoxy-n,n’-bis(3-pyridylmethyl)-isophthalamid;4-methoxy-N,N'-bis(3-pyridylmethyl)isophthaldiamide;Isophthalamide, 4-methoxy-N,N'-bis(3-pyridylmethyl)-;n,n’-bis(3-pyridinylmethyl)-4-methoxy-3-benzenedicarboxamide;4-METHOXY-N,N'-BIS(3-PYRIDINYLMETHYL)-1,3-BENZENEDICARBOXAMIDE

CBNumber:: CB7167904

Molecular Formula:: C21H20N4O3

Molecular Weight:: 376.41

MDL Number:: MFCD00866792

MOL File:: 32828-81-2.mol

Last updated:2023-09-04 15:51:00

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Picotamide Properties

Melting point	128-131℃
Boiling point	668.1±55.0 °C(Predicted)
Density	1.246±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml with warming).
pka	13.31±0.46(Predicted)
form	White solid.
color	White
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
FDA UNII	654G2VCI4Q
ATC code	B01AC03

SAFETY

Risk and Safety Statements

Hazard statements	H303
Precautionary statements	P270-P301+P312-P403-P501c
WGK Germany	2
RTECS	CZ2235500
Toxicity	LD50 i.p. in male mice: 1205 mg/kg (Orzalesi, Selleri, 1976)

Picotamide price More Price(9)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	P8477	Picotamide	32828-81-2	5mg	$277	2024-03-01	Buy
Alfa Aesar	J67232	Picotamide, 98%	32828-81-2	10mg	$144.9	2023-01-06	Buy
Cayman Chemical	21690	Picotamide ≥98%	32828-81-2	5mg	$62	2024-03-01	Buy
Cayman Chemical	21690	Picotamide ≥98%	32828-81-2	10mg	$109	2024-03-01	Buy
Cayman Chemical	21690	Picotamide ≥98%	32828-81-2	25mg	$239	2024-03-01	Buy

Product number	Packaging	Price	Buy
P8477	5mg	$277	Buy
J67232	10mg	$144.9	Buy
21690	5mg	$62	Buy
21690	10mg	$109	Buy
21690	25mg	$239	Buy

Picotamide Chemical Properties,Uses,Production

Description

Picotamide is an unique antithrombotic agent which acts by selectively inhibiting thromboxane synthesis and blocking platelet thromboxane receptors without affecting prostaglandin synthesis. It is reported to be useful in the treatment of myocardial infarction, cerebrovascular disorders, pulmonary embolism and atherosclerosis.

Originator

Manetti-Roberts (Beecham (Italy)

Uses

Keratolytic.

Uses

Picotamide is a dual inhibitor of thromboxane A2 and thromboxane A2 synthase. It is used in aptamers for targeting coagulation factor XIII and there used for treatment of thrombosis.

Definition

ChEBI: 4-methoxy-N1,N3-bis(3-pyridinylmethyl)benzene-1,3-dicarboxamide is a member of benzamides.

brand name

Plactidil

References

Modesti, et al. (1989), Competitive inhibition of platelet thromboxane A2 receptor binding by picotamide; Eur. J. Pharmacol.. 169 85 Modesti, et al. (1991), Acute reduction of TxA2 platelet binding sites after in vivo administration of a TxA2 inhibitor; Br. J. Pharmacol.. 31 439 Ratti et al. (1998), Picotamide, an antithromboxane agent. Inhibits the migration and proliferation of arterial myocytes; Eur. J. Pharmacol. 355 77

Picotamide synthesis

Synthesis of Picotamide from 3-(Aminomethyl)pyridine and 4-methoxyisophthaloyl dichloride

Picotamide Preparation Products And Raw materials

Raw materials

Preparation Products

Picotamide Suppliers

Global( 49)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9923	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
LGM Pharma	1-(800)-881-8210	inquiries@lgmpharma.com	United States	2127	70
China Langchem Inc.	0086-21-58956006		China	7815	57
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	14059	65
Shanghai TaoSu Biochemical Technology Co., Ltd.	021-33632979	info@tsbiochem.com	China	8073	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58

Supplier	Advantage
Hefei TNJ Chemical Industry Co.,Ltd.	58
Hefei Hirisun Pharmatech Co., Ltd	58
TargetMol Chemicals Inc.	58
LEAPCHEM CO., LTD.	58
Aladdin Scientific	58
LGM Pharma	70
China Langchem Inc.	57
BOC Sciences	65
Shanghai TaoSu Biochemical Technology Co., Ltd.	58
Shanghai EFE Biological Technology Co., Ltd.	58

Picotamide Spectrum

Picotamide(32828-81-2)¹HNMR

32828-81-2(Picotamide)Related Search:

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(4-METHOXY-BENZYL)-PYRIDIN-3-YLMETHYL-AMINE ISOPHTHALAMIDE (2-METHOXY-BENZYL)-PYRIDIN-3-YLMETHYL-AMINE 5-Methylsalicylamide 3-carbamyl-(3'-picolyl)-4-methoxy-1-benzamide

Picotamide

1of3

4-METHOXY-N,N'-BIS(3-PYRIDINYLMETHYL)-1,3-BENZENEDICARBOXAMIDE PICOTAMIDE 4-methoxy-n,n’-bis(3-pyridylmethyl)-isophthalamid 4-methoxy-n,n’-bis(3-pyridylmethyl)isophthalamide g137 n,n’-bis(3-picolyl)-4-methoxyisophthalamide n,n’-bis(3-pyridinylmethyl)-4-methoxy-1,3-benzenedicarboxamide n,n’-bis(3-pyridinylmethyl)-4-methoxy-3-benzenedicarboxamide 4-methoxy-N,N'-bis(3-pyridylmethyl)isophthaldiamide -1,3-Benzenedicarboxamide, N,N'-bis(3-pyridinylmethyl)-4-methoxy Isophthalamide, 4-methoxy-N,N'-bis(3-pyridylmethyl)- N,N’-Bis(3-Pyridinylmethyl)-4-Me 4-methoxy-1-N,3-N-bis(pyridin-3-ylmethyl)benzene-1,3-dicarboxamide 1,3-Benzenedicarboxamide, 4-methoxy-N1,N3-bis(3-pyridinylmethyl)- inhibit,Picotamide,Inhibitor,Prostaglandin Receptor,Antiplatelet,Microalbuminuria,Carotid plaques 32828-81-2 C21H20N4O3H2O C21H20N4O3 Enzymes, Inhibitors, and Substrates Enzyme Inhibitors Enzyme Inhibitors by Enzyme Thromboxane synthase R to Z BioChemical Biochemicals and Reagents