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Leuprorelin acetate

Anti-cancer drugs
Leuprorelin acetate
Leuprorelin acetate structure
CAS No.
74381-53-6
Chemical Name:
Leuprorelin acetate
Synonyms
lupron;tap-144;Prostap;Procrin;TPA-144;DC-2-269;tap-144-sr;LEUPROLIDE;Abbott 43818;Procren Depot
CBNumber:
CB7174300
Molecular Formula:
C59H84N16O12.C2H4O2
Formula Weight:
1269.46
MOL File:
74381-53-6.mol

Leuprorelin acetate Properties

Melting point:
150-155°C
storage temp. 
−20°C
Merck 
14,5457
InChIKey
RGLRXNKKBLIBQS-XNHQSDQCSA-N
FDA UNII
37JNS02E7V
NCI Dictionary of Cancer Terms
leuprolide acetate; Lupron
Proposition 65 List
Leuprolide Acetate
SAFETY
  • Risk and Safety Statements
Safety Statements  22-24/25
WGK Germany  2
RTECS  OH6390000
HS Code  29371900

Leuprorelin acetate price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich L0399 Leuprolide acetate salt ≥98% (HPLC) 74381-53-6 1mg $96.1 2019-12-02 Buy
Sigma-Aldrich 1358503 Leuprolide acetate salt 74381-53-6 200mg $3792.6 2019-12-02 Buy
Cayman Chemical 22275 Leuprorelin (acetate) ≥98% 74381-53-6 1mg $25 2020-06-24 Buy
Cayman Chemical 22275 Leuprorelin (acetate) ≥98% 74381-53-6 5mg $75 2020-06-24 Buy
Sigma-Aldrich L0399 Leuprolide acetate salt ≥98% (HPLC) 74381-53-6 5mg $337 2019-12-02 Buy

Leuprorelin acetate Chemical Properties,Uses,Production

Anti-cancer drugs

Leuprolide acetate is a commonly used hormone anti-cancer drug, , it is a acetate of leuprolide which is a nonapeptide synthetic analogue of LHRH( one kind decapeptide), it is a LH-RH antagonist, LHRH is produced by the hypothalamus, it can promote pituitary for the release of gonadotropins and follicle-stimulating hormone (FSH) and luteinizing hormone (LH). This product’s structure is similar to LHRH, its acting on the anterior pituitary which prompts FSH, LH release function, increases serum concentrations of testosterone and dihydro testosterone. It is used as maintenance therapy for advanced prostate cancer clinically, but in about one week after use of the product, the number of active receptors will be reduced, and gonadotropin secretion will be reduced.After 2 to 4 weeks, the concentration of testosterone and dihydro testosterone can be reduced to castration levels. After the withdrawal, gonadotropin and androgen concentrations can be recovered to normal.
Note that this product is not effective when administered orally, subcutaneous or intramuscular administration has good absorption. T1/2 of parenteral administration is 3 h. There is no accumulation in the body, unchanged drugs and its metabolites in urine excretion rates are2.9% and 1.5%, respectively. Ethanol can enhance the role of this product, the course of treatment should not drink, in case it is difficult to control the incidence of adverse reactions. In the first week of the course of treatment ,patients should try to be hospitalized for monitoring, choose an experienced physician to guide treatment to prevent severe neurological complications, urinary tract obstruction. Injection site should often vary.
The above information is edited by the chemicalbook of Tian Ye.

Description

Leuprolide acetate is a potent analog of LH-RH useful in achieving a medical castration in the treatment of advanced prostate cancer. It has also been investigated for the treatment of advanced breast cancer.

Chemical Properties

Fluffy Solid

Originator

Takeda (Japan)

Uses

Leuprolide acetate USP (Leupron) is used to treat Prostatic carcinoma.

Uses

Synthetic nonapeptide agonist analog of LH-RH. Antineoplastic (hormonal).

Definition

ChEBI: An acetate salt obtained by combining the nonapeptide leuprolide with acetic acid. A long lasting GnRH analog, LH-Rh agonist. It is a synthetic nonapeptide analogue of gonadotropin-releasing hormone, and is used as a subcutaneous hydrogel implant for the t eatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty.

brand name

Eligard (QLT); Lupron(TAP); Viadur (ALZA);CARCINIL.

Leuprorelin acetate Preparation Products And Raw materials

Raw materials

Preparation Products


Leuprorelin acetate Suppliers

Global( 173)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 35434 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22626 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3014 60
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24723 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30045 58
Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2645 58
GIHI CHEMICALS CO.,LIMITED
08657186217390
sales@gihichemicals.com CHINA 309 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23977 58
Chongqing Chemdad Co.,Ltd
+86-19923101450
sales@chemdad.com CHINA 4001 58
Kono Chem Co., Ltd
+86-132 8924 6953(Whatsapp/Wechat)
+86-29-86107037 info@konochemical.com CHINA 2995 58

View Lastest Price from Leuprorelin acetate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-08-31 Leuprorelin acetate
74381-53-6
US $7.00 / KG 1KG 99% 100KG career henan chemical co

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