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Fenspiride hydrochloride

Pharmacological effects Indications
Fenspiride hydrochloride
Fenspiride hydrochloride structure
CAS No.
5053-08-7
Chemical Name:
Fenspiride hydrochloride
Synonyms
jp428;Erespal;NAT 333;espiran;fluiden;Tegencia;Decaspir;pneumorel;Viarespan;NDR 5998A
CBNumber:
CB7295887
Molecular Formula:
C15H21ClN2O2
Formula Weight:
296.79
MOL File:
5053-08-7.mol

Fenspiride hydrochloride Properties

Melting point:
235-238°C (dec.)
storage temp. 
Refrigerator
form 
powder
color 
white
FDA UNII
832NBX878V
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xn
Risk Statements  20/21/22
Safety Statements  36
WGK Germany  3
RTECS  RO0375000
Toxicity LD50 i.v. in mice: 106 mg/kg; orally in rats: 437 mg/kg (LeDouarec)

Fenspiride hydrochloride price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical F1211 Fenspiride Hydrochloride 5053-08-7 1G $55 2021-03-22 Buy
TCI Chemical F1211 Fenspiride Hydrochloride 5053-08-7 5G $154 2021-03-22 Buy
Cayman Chemical 25512 Fenspiride (hydrochloride) ≥95% 5053-08-7 10g $79 2021-03-22 Buy
Cayman Chemical 25512 Fenspiride (hydrochloride) ≥95% 5053-08-7 5g $44 2021-03-22 Buy
Cayman Chemical 25512 Fenspiride (hydrochloride) ≥95% 5053-08-7 25g $176 2021-03-22 Buy

Fenspiride hydrochloride Chemical Properties,Uses,Production

Pharmacological effects

As an α adrenergic and H1 histamine receptor antagonist, Fenspiride has been shown to be antiinflammatory, anti-allergic and antioxidant. Fenspiride inhibited SO2-induced goblet cell hyperplasia in rats, with concomitant inhibition of increased hexose and fucose, indicative of mucus hypersecretion, in lavage fluid. Fenspiride also exhibits neuronal inhibitory activity. For example, in guinea pigs, it reverses capsaicin-induced and citric acid-induced bronchoconstriction and cough, and inhibits cholinergic and non-adrenergic, non-cholinergic (NANC) neural contraction of isolated bronchi.

Indications

Fenspiride hydrochloride is a bronchodilator, which was used as a drug in the treatment of certain respiratory diseases. Finsecbili hydrochloride against serotonin, dilating bronchial smooth muscle, the intensity of action is between isoproterenol and theophylline, in addition to reducing the resistance of air movement in the lungs, experiments have shown that this product has dilated bronchial smooth muscle, antitussive, antipyretic and analgesic effects. Suitable for chronic bronchitis, bronchial asthma and chronic respiratory insufficiency.  In Russia it was approved for the treatment of acute and chronic inflammatory diseases of ENT organs and the respiratory tract, as well as for maintenance treatment of asthma (like rhinopharyngitis, laryngitis, tracheobronchitis, otitis and sinusitis).

Chemical Properties

Pale Yellow Solid

Originator

Viarespan,Servier,France,1969

Uses

Antiinflammatory;Bradykinin antagonist

Uses

Bronchodilator with anti-inflammatory properties. Inhibits mucus secretion and reduces the release of tachykinins at a prejunctional level by its anti-muscarinic action. It also may be an antagonist at α adrenergic and H1 histamine receptors.

Manufacturing Process

A solution of 192 g of 1-phenethyl-4-hydroxy-4-aminomethyl piperidine in 800 cc of diethylcarbonate is heated for 2? hours to reflux at about 80°C in the presence of sodium methylate (prepared for immediate use from 2 g of sodium). After this time, the ethyl alcohol formed during the reaction is slowly distilled while the maximum temperature is reached. The excess ethyl carbonate is distilled under reduced pressure. A crystallized residue is then obtained, which is stirred with 400 cc of water and 400 cc of ether. The solution is filtered and 125 g (77.6%) of practically pure product melting at 232°C to 233°C, are obtained.
The starting material was prepared in a yield of 58% by reduction of the corresponding cyanohydrin. It in turn was prepared from 1-(2-phenylethyl)-4- piperidone and potassium cyanide to give the cyanohydrin which was reduced by lithium aluminum hydride.

Therapeutic Function

Bronchodilator

Fenspiride hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Fenspiride hydrochloride Suppliers

Global( 107)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Nanjing Gold Pharmaceutical Technology Co. Ltd.
025-84209270 15906146951
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Shanghai Yingrui Biopharma Co., Ltd.
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View Lastest Price from Fenspiride hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-08-18 Fenspiride hydrochloride
5053-08-7
US $1.00 / g 1g 99% 10tons Hebei Binshare New Material Co. Ltd
2021-07-20 Fenspiride hydrochloride
5053-08-7
US $0.00-0.00 / KG 5mg 99% HPLC 2000tons Shaanxi Dideu Medichem Co. Ltd
2021-06-08 Hot selling Fenspiride CAS:5053-08-7 in stock
5053-08-7
US $1.00 / KG 1KG 99% 1ton Shanxi Naipu Import and Export Co.,Ltd

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