Sodium Butyrate
- CAS No.
- 156-54-7
- Chemical Name:
- Sodium Butyrate
- Synonyms
- NAB;SODIUM BUTANOATE;SODIUM N-BUTYRATE;BUTYRIC ACID SODIUM SALT;N-BUTYRIC ACID SODIUM SALT;Sodium Butyrate - CAS 156-54-7 - Calbiochem;Natriumbutyrat;butyratesodium;SODIUM BUTYRATE;BUTYRIC ACID NA
- CBNumber:
- CB7391358
- Molecular Formula:
- C4H7NaO2
- Molecular Weight:
- 110.09
- MDL Number:
- MFCD00002816
- MOL File:
- 156-54-7.mol
- MSDS File:
- SDS
Melting point | 250-253 °C (lit.) |
---|---|
Density | 1.324 g/cm3 (30℃) |
storage temp. | Store below +30°C. |
solubility | Methanol (Slightly), Water (Slightly) |
form | Amorphous Powder |
color | White |
Water Solubility | soluble |
Sensitive | Hygroscopic |
BRN | 3629439 |
Stability | Stable. Incompatible with strong acids. |
InChI | InChI=1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1 |
InChIKey | MFBOGIVSZKQAPD-UHFFFAOYSA-M |
SMILES | C(CC)C([O-])=O.[Na+] |
LogP | 0.777 (est) |
CAS DataBase Reference | 156-54-7(CAS DataBase Reference) |
FDA UNII | 8RAS91C36W |
NIST Chemistry Reference | Sodium butyrate(156-54-7) |
NCI Drug Dictionary | sodium butyrate |
EPA Substance Registry System | Butanoic acid, sodium salt (156-54-7) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302-H315-H319 | |||||||||
Precautionary statements | P264-P270-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
Hazard Codes | Xn | |||||||||
Risk Statements | 36/37/38-68 | |||||||||
Safety Statements | 37/39-26-24/25-36/37 | |||||||||
RTECS | ET6400000 | |||||||||
F | 3-10 | |||||||||
HS Code | 29156000 | |||||||||
NFPA 704 |
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Sodium Butyrate price More Price(43)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 8.20236 | Sodium butyrate for synthesis | 156-54-7 | 250g | $148 | 2024-03-01 | Buy |
Sigma-Aldrich | 8.20236 | Sodium butyrate for synthesis | 156-54-7 | 1kg | $519 | 2024-03-01 | Buy |
Sigma-Aldrich | 8.17500 | Sodium butyrate special quality | 156-54-7 | 100g | $64 | 2024-03-01 | Buy |
Sigma-Aldrich | 1613600 | Sodium butyrate United States Pharmacopeia (USP) Reference Standard | 156-54-7 | 25mg | $436 | 2024-03-01 | Buy |
Sigma-Aldrich | 07596 | Sodium butyrate certified reference material, TraceCERT | 156-54-7 | 100mg | $127 | 2024-03-01 | Buy |
Sodium Butyrate Chemical Properties,Uses,Production
Chemical Properties
Sodium butyrate is a white crystalline solid with an unpleasant smell that occurs in butter and animal fat as the glycerol ester. It is the sodium salt of butyric acid. It has various effects on cultured mammalian cells including inhibition of proliferation, induction of differentiation and induction or repression of gene expre.
Uses
Sodium butyrate has been used:
as a component in homogenization and immunoprecipitation buffer for HDAC inhibition in fly embryos and insect s2 cells.
as histone deacetylase inhibitor in breast cancer cell line MDA-MB-231, analysed by cell viability assay and viral replication assay.
to enhance the production of recombinant tissue-plasminogen activator (t-PA) in Chinese hamster ovary (CHO) cells in a bioreactor.
Uses
Sodium Butyrate is an inhibitor of histone deacetylase activity (HDAC) resulting in improvement of physiological disorders such as Duchenne muscular dystropy. In addition it is a possible antitumor agent when used in conjunction with other cytotoxic agents as they have been shown to treat carcinomas.
Definition
ChEBI: Sodium butyrate is an organic sodium salt resulting from the replacement of the proton from the carboxy group of butyric acid by a sodium ion. It has a role as an EC 3.5.1.98 (histone deacetylase) inhibitor and a geroprotector. It contains a butyrate.
benefits
Sodium butyrate, a butyrate, is used in supplements. The benefits of butyrate begin in the gut and extend to a host of other important body systems. It could fuel the gut lining, support healthy gut permeability. promote a healthy inflammation response in the gut, may fight colonic diseases and cancers, promote healthy blood sugar levels, supports normal proliferation of healthy yeast levels, promote cell differentiation, regulate the immune system , combat brain fog and improve sleep, and supports healthy blood pressure levels.
Biological Activity
Histone deacetylase inhibitor. Restores contextual memory in a transgenic mouse model of Alzheimer's disease. Shown to induce pancreatic progenitor formation. Directs the differentiation of mouse embryonic stem cells into hepatocytes when used in combination with the cytokine Activin A.
Biochem/physiol Actions
Sodium butyrate is a short-chain fatty acid that inhibits histone deacetylase (HDAC) in the millimolar range. Decreases Ca2+ release from intracellular stores. Induces apoptosis in several cell lines. Sodium butyrate induces the production of recombinant protein in Chinese hamster ovary (CHO) cells and other human cell lines. Sodium butyrate affects the proteome and gene expression pathways in the cells. It represses cell cycle related genes and modifies the genes involved in cell metabolism and apoptosis.
storage
Room temperature
Purification Methods
Sodium butyrate [156-54-7] M 110.1. Prepare it by neutralising the acid with Na2CO3, and recrystallising it from EtOH. [Beilstein 2 IV 779.]
Sodium Butyrate Preparation Products And Raw materials
Raw materials
Preparation Products
1of2
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Across Biotech Jinan Co LTD | +8613031735486 | frank@acrossbiotech.com | China | 105 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3002 | 58 |
Hebei Shengyang Water Conservancy Engineering Co., Ltd. | +8615373025980 | clara@hbshengyang.com | China | 774 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21687 | 55 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 | info@tnjchem.com | China | 2989 | 55 |
career henan chemical co | +86-0371-86658258 15093356674; | sales@coreychem.com | China | 29914 | 58 |
SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2931 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8829 | 58 |
View Lastest Price from Sodium Butyrate manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-05-08 | Sodium Butyrate
156-54-7
|
US $18.00-18.00 / kg | 1kg | 99.9 | 5000 | Hebei Shengyang Water Conservancy Engineering Co., Ltd. | ||
2024-05-07 | Sodium Butyrate
156-54-7
|
US $120.00 / kg | 1kg | 99% | 20ton | Hebei Zhuanglai Chemical Trading Co.,Ltd | ||
2024-03-31 | Sodium Butyrate
156-54-7
|
US $30.00-10.00 / BOX | 10BOX | 99 | 20TONS | Shanghai Chinqesen Biotechnology Co., Ltd. |
- Sodium Butyrate
156-54-7
- US $18.00-18.00 / kg
- 99.9
- Hebei Shengyang Water Conservancy Engineering Co., Ltd.
- Sodium Butyrate
156-54-7
- US $120.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co.,Ltd
- Sodium Butyrate
156-54-7
- US $30.00-10.00 / BOX
- 99
- Shanghai Chinqesen Biotechnology Co., Ltd.