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Vinblastine sulfate

Vinblastine sulfate
Vinblastine sulfate structure
CAS No.
143-67-9
Chemical Name:
Vinblastine sulfate
Synonyms
VLB;exal;velbe;velban;Velsar;29060le;nsc49842;Periblastine;rozevinsulfate;Vinblastine-d3
CBNumber:
CB7407655
Molecular Formula:
C46H60N4O13S
Formula Weight:
909.05
MOL File:
143-67-9.mol

Vinblastine sulfate Properties

Melting point:
267 °C (dec.)(lit.)
alpha 
-21.7 º (c=2, CH3OH 21 ºC)
storage temp. 
2-8°C
solubility 
H2O: 10 mg/mL
form 
powder
color 
white
PH
3.5~5.0 (1g/l, 25℃)
Water Solubility 
>=1 g/100 mL at 24.5 ºC
Merck 
13,10044
BRN 
3659812
InChIKey
KDQAABAKXDWYSZ-PNYVAJAMSA-N
CAS DataBase Reference
143-67-9(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
N00W22YO2B
Proposition 65 List
Vinblastine Sulfate
EPA Substance Registry System
Vinblastine sulfate (143-67-9)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H315-H318-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P280-P301+P312+P330-P305+P351+P338+P310-P304+P340+P312
Hazard Codes  Xn,T
Risk Statements  22-37/38-41-61-36/37/38-63-23/24/25
Safety Statements  26-36/39-53-45-37/39-36/37/39
RIDADR  1544
WGK Germany  3
RTECS  YY8400000
8-10
HazardClass  6.1(a)
PackingGroup  II
HS Code  29399990
Toxicity LD50 i.v. in mice: 9.5 mg/kg (Lu, Meistrich)

Vinblastine sulfate price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 677175-M Vinblastine Sulfate Antitumor alkaloid drug. 143-67-9 10mg-m $130 2019-12-02 Buy
Sigma-Aldrich 1713004 Vinblastine sulfate United States Pharmacopeia (USP) Reference Standard 143-67-9 50mg $798.7 2019-12-02 Buy
Alfa Aesar J63598 Vinblastine sulfate 98% 143-67-9 50mg $410 2019-12-02 Buy
Alfa Aesar J63598 Vinblastine sulfate 98% 143-67-9 10mg $97.8 2019-12-02 Buy
Cayman Chemical 11762 Vinblastine (sulfate) ≥95% 143-67-9 5mg $45 2018-11-13 Buy

Vinblastine sulfate Chemical Properties,Uses,Production

Chemical Properties

Crystalline Solid

Uses

antineoplastic, spindle poison

Uses

Labelled Vinblastine (V314000). Antitumor alkaloid isolated from periwinkle, Vinca rosea Linn., Apocynaceae; inhibits microtubule assembly. An antineoplastic.

Uses

Vinblastin sulfate USP (Velban) is used to treat Hodgkin’s disease; lymphosarcoma; reticulum cell sarcoma; neuroblastoma; choriocarcinoma; carcinoma of breast, lung, oral cavity, testis, bladder; acute and chronic leukemia; histiocytosis; mycosis fungoides.

brand name

Velban (Lilly).

General Description

An anticancer drug. White to slightly yellow crystalline powder.

General Description

Vinblastine sulfate is available as a powder in 10-mg vials and as a solution in 10- and 25-mL vials for IV administrationin the treatment of various cancers including Hodgkin’sdisease, lymphocytic lymphoma, histiocytic lymphoma, advancedmycosis fungoides, advanced testicular carcinoma,and Kaposi sarcoma. It has also been used in treating choriocarcinomaand breast cancer when other therapies havefailed. Vinblastine is part of the ABVD (adriamycin,bleomycin, vinblastine, and dacarbazine) regimen used inthe treatment of Hodgkin’s lymphoma. This may be alternatedwith the MOPP regimen. Extravasation is a concernwith the vincas and is treated by administration ofhyaluronidase and application of heat. Hyaluronidase hydrolyzeshyaluronic acid, a polysaccharide component of theconnective tissue. In so doing, the drug may increase diffusionout of the area of extravasation more quickly, preventingthe buildup of toxic levels. Vinblastine is highly proteinbound and metabolized by CYP to the 4-O-desacetylmetabolite, which has been shown to be active although onlysmall amounts have been recovered in the bile and feces. Themetabolism of the vinca alkaloids has not been well characterized.Vinblastine is eliminated primarily in the feces;however, little of the unchanged drug has been recovered.Metabolism appears to involve CYP3A but other than thedesacetyl derivative, other metabolites have not been characterized.The elimination half-life for vinblastine is 25 hours.Like vinorelbine, myelosuppression is commonly seen withvinblastine and is dose limiting. Inflammation of the GI tractis more commonly seen with vinblastine than vincristine.Nausea and vomiting may also occur. Other adverse effectsinclude alopecia, secretion of antidiuretic hormone,headache, and depression. Neurotoxicity is mild comparedwith vincristine, but peripheral neuropathy may be seen. Anadditional manifestation of this neurotoxicity.

Air & Water Reactions

Water soluble..Rapidly hydrolyzes.

Reactivity Profile

Vinblastine sulfate is sensitive to light, hydrolysis, oxidation, and heat. Vinblastine sulfate is very hygroscopic. .

Health Hazard

SYMPTOMS: Symptoms of exposure to Vinblastine sulfate include temporary mental depression, paresthesias, loss of deep-tendon reflexes, headache, convulsions, psychoses; dysfunction of the autonomic nervous system, with marked constipation, paralytic ileus, urinary retention, bilateral pain and tenderness of the parotid glands associated with dryness of the mouth, sinus tachycardia; nausea, vomiting, anorexia, diarrhea; loss of hair, vesicular mucositis of the mouth, and dermatitis.

Fire Hazard

Flash point data for Vinblastine sulfate are not available; however Vinblastine sulfate is probably combustible.

Biological Activity

Anticancer agent; microtubule disrupter. Induces apoptosis in cultured hepatocytes and human lymphoma cells.

Safety Profile

Poison by ingestion, intraperitoneal, and intravenous routes. An experimental teratogen. Human systemic effects by intravenous route: blood leukopenia and hair changes. Experimental reproductive effects. Questionable carcinogen. Human mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SOx. See also VINCALEUKOBLASTINE and SULFATES.

Veterinary Drugs and Treatments

Vinblastine may be employed in the treatment of lymphomas, carcinomas, mastocytomas, and splenic tumors in small animals. It is more effective than vincristine in the treatment of canine mast cell tumors.

Purification Methods

Crystallise the sulfate from MeOH or EtOH and dry it in vacuo over conc H2SO4. The free base crystallises from EtOH or MeOH m 211-216o (+ 2MeOH .1 H2O) and forms a stable etherate from Et2O with m 201-211o, and [] D +42o (CHCl3), and UV max at 214 and 259nm (log  4.73 and 4.21). The dihydrochloride has m 244-246o(dec)(MeOH). It is a monoamine oxidase B inhibitor and induces microtubule aggregation. It is an antineoplastic drug for Hodgkin’s lymphoma. [Neuss et al. J Am Chem Soc 81 4754 1959, Jong-KeunSon et al. J Med Chem 33 1845 1990, Warfield & Bouck Science 186 1219 1974, Beilstein 26 III/IV 3167.]

Vinblastine sulfate Preparation Products And Raw materials

Raw materials

Preparation Products


Vinblastine sulfate Suppliers

Global( 298)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hainan Xiyuan Chemical Technology Co., Ltd.
+86-15008981366
15008981366@163.com CHINA 9 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21829 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22626 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
Hebei Chisure Biotechnology Co., Ltd.
+8613292890173
0311 66567340 luna@speedgainpharma.com CHINA 1011 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30050 58
Chengdu GLP Biotech Co., Ltd
13350802083
scglp@glp-china.com CHINA 1008 58
Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2645 58
Nanjing Dolon Biotechnology Co.,Ltd.
18905173768
sales@dolonchem.com CHINA 2972 58

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View Lastest Price from Vinblastine sulfate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-05 Vinblastine sulfate
143-67-9
US $10.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.
2019-12-04 Vinblastine Sulfate
143-67-9
US $0.00 / mg 5mg ≥98%(HPLC) 10 g Shanghai Standard Technology Co., Ltd.
2020-04-30 Vinblastine sulfate
143-67-9
US $0.00-0.00 / 公斤 1公斤 99.0% 800 ton Shaanxi Dideu Medichem Co. Ltd

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