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Cefdinir

Brand Name(s) in US
Cefdinir
Cefdinir structure
CAS No.
91832-40-5
Chemical Name:
Cefdinir
Synonyms
CFDN;Omnice;FK-482;Cefzon;CI 983;Omnicef;Novacef;cefdinyl;bmy28488;CEFDINIR
CBNumber:
CB7483101
Molecular Formula:
C14H13N5O5S2
Formula Weight:
395.41
MOL File:
91832-40-5.mol

Cefdinir Properties

Melting point:
>180°C dec.
Density 
1.89±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
dilute HCl: slightly soluble
pka
9.70(at 25℃)
form 
solid
Water Solubility 
Soluble in water
λmax
295nm(DMSO)(lit.)
Merck 
14,1920
CAS DataBase Reference
91832-40-5(CAS DataBase Reference)
FDA UNII
CI0FAO63WC
ATC code
J01DD15
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H317-H334
Precautionary statements  P261-P272-P280-P284-P302+P352+P333+P313+P363-P304+P340+P342+P311-P501
WGK Germany  3
RTECS  XI0367250
HS Code  2941906000
Toxicity LD50 orl-rat: >5600 mg/kg IYKEDH 23,93,1992

Cefdinir price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C7118 Cefdinir ≥95% (HPLC) 91832-40-5 1g $136 2021-03-22 Buy
TCI Chemical C3111 Cefdinir >97.0%(HPLC)(T) 91832-40-5 1g $91 2021-03-22 Buy
TCI Chemical C3111 Cefdinir >97.0%(HPLC)(T) 91832-40-5 5g $228 2021-03-22 Buy
Alfa Aesar J66447 Cefdinir, 95% 91832-40-5 5g $383 2021-03-22 Buy
Alfa Aesar J66447 Cefdinir, 95% 91832-40-5 1g $108 2021-03-22 Buy

Cefdinir Chemical Properties,Uses,Production

Brand Name(s) in US

Omnicef

Description

Cefdinir is an orally active, beta-lactamase stable cephalosporin with a broad spectrum of activity. Compared to other oral cephalosporins, cefdinir is more potent against Gram-positive bacteria, especially Staphylococci. Its activity against Gram-negative bacteria such as E.coli,K. pneumoniae and P.mirabilis is similar to cefixime, but superior to cefaclor and cephalexin.

Chemical Properties

Pale Yellow Solid

Originator

Fujisawa (Japan)

Uses

A Cephalosporin antibiotic structurally similar to Cefixime

Uses

antihypertensive, ACE inhibitor

Definition

ChEBI: A cephalosporin compound having 7beta-2-(2-amino-thiazol-4-yl)-2-[(Z)-hydroxyimino]-acetylamino- and 3-vinyl side groups.

Manufacturing Process

By interaction of 7-amino-8-oxo-3-vinyl-5-thia-1-azabicyclo(4.2.0)oct-2-ene- 2-carboxylic acid 4-methoxyphenyl ester with 4-bromoacetyl bromide was prepared 7-(4-bromo-3-oxo-butyrylamino)-8-oxo-3-vinyl-5-thia-1-azabicyclo (4.2.0)oct-2-ene-2-carboxylic acid 4-methoxyphenyl ester. The active methylene group in that product was then nitrosated with sodium nitrite. The initial product spontaneously tautomerizes to afford 7-(4-bromo-2- hydroxyimino-3-oxo-butyrylamino)-8-oxo-3-vinyl-5-thia-1-azabicyclo(4.2.0) oct-2-ene-2-carboxylic acid 4-methoxyphenyl ester. By the reaction of that compound with thiourea and then with trifluoroacetic acid was obtained (6R,7R)-7-(2-(2-amino-4-thiazolyl)glyoxylamido)-8-oxo-3-vinyl-5-thia-1- azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid sodium nitrite, (Z)-oxime (Cefdinir sodium nitrile).
In practice it is usually used as free acid.
Synthesis of 7β-[2-(2-aminothiazol-4-yl)-2-(Z)-(trytiloxyimino)acetamido]-3- vinyl-3-cephem-4-carboxylic acid x p-toluenesulfonic acid x 2 N,N-dimethylacetamide (the precursor of Cefdinir) was described in Patent US 6,093,814.

brand name

Cefzon

Therapeutic Function

Antibiotic

Antimicrobial activity

An oral cephalosporin similar in structure to cefixime, but with a slightly modified side chain at the 7-amino position. Activity is similar to that of cefixime, but it is more active, especially against staphylococci. It is not hydrolyzed by staphylococcal or the common plasmid-mediated enterobacterial β-lactamases. An enhancing effect on phagocytosis has been demonstrated in vitro.
Oral absorption is about 35%. A 200 mg oral dose achieves a plasma concentration of 1 mg/L after c. 3 h. Absorption is reduced after a fatty meal. Concentrations equal to or higher than corresponding plasma levels were present in blister fluid 6–12 h after administration of an oral dose. The plasma halflife is 1.5 h. Protein binding is 60–70%. A total of 12–20% of the dose was excreted in the urine within 12 h, the renal elimination declining with increasing dose. The elimination half-life and peak plasma concentration are increased in renal failure. About 60% of the drug is removed by hemodialysis.
Side effects and uses are those common to oral cephalosporins.

Safety Profile

Moderately toxic by ingestion andintravenous routes. Low toxicity by intraperitoneal andsubcutaneous routes. Experimental reproductive effects.When heated to decomposition it emits toxic vapors ofNOx and SOx.

Cefdinir Preparation Products And Raw materials

Raw materials

Preparation Products


Cefdinir Suppliers

Global( 323)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20012 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20911 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Guangzhou PI PI Biotech Inc
+8618371201331
020-81716319 sales@pipitech.com;87478684@qq.com China 3245 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29955 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998
sales@czwytech.com CHINA 914 58
HubeiwidelychemicaltechnologyCo.,Ltd
18627774460
faith@widelychemical.com CHINA 743 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19752 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58

View Lastest Price from Cefdinir manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-24 Cefdinir
91832-40-5
US $10.00 / Kg/Bag 1Kg/Bag 99% 20 Tons Hebei Zhanyao Biotechnology Co. Ltd
2021-09-29 Cefdinir
91832-40-5
US $0.00-0.00 / Kg/Drum 100g 99%min 100kg WUHAN FORTUNA CHEMICAL CO., LTD
2021-07-13 Cefdinir
91832-40-5
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

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