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Tylosin

Tylosin
Tylosin structure
CAS No.
1401-69-0
Chemical Name:
Tylosin
Synonyms
Tylon;Vetil;TYLOSIN;TYLAN50;Tylosine;tylocine;Vetil(R);Tylan 100;fradizine;Tylosin A
CBNumber:
CB7708088
Molecular Formula:
C46H77NO17
Formula Weight:
916.1
MOL File:
1401-69-0.mol

Tylosin Properties

Melting point:
135-137°C
alpha 
D25 -46° (c = 2 in methanol)
Boiling point:
796.05°C (rough estimate)
Density 
1.1424 (rough estimate)
refractive index 
1.5280 (estimate)
storage temp. 
Sealed in dry,2-8°C
pka
pKa 7.73(H2O t = 25 I = 0.167) (Uncertain)
Water Solubility 
H2O: soluble 50 mg/mL
Stability:
Solutions are stable at pH 4-9 (most stable at pH 7);
Below pH 4 tylosin B (desmycosin) is formed as a result of acid hydrolysis;
In neutral and alkaline pH – tylosin aldol (TAD) is formed together with polar degradation products of unknown identity;
When tylosin solution is exposed to daylight, a photodegradation product - isotylosin A (isoTA) is formed.
FDA 21 CFR
556.746; 558.625; 558.4
EWG's Food Scores
4
FDA UNII
YEF4JXN031
EPA Substance Registry System
Tylosin (1401-69-0)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS08,GHS09
Signal word  Danger
Hazard statements  H317-H334-H400
Precautionary statements  P261-P280-P284-P304+P340-P342+P311
Hazard Codes  Xn,N
Risk Statements  42/43-50
Safety Statements  36-61-45-36/37-22
HS Code  2941906000
Toxicity Tylosin base and its salts were shown to be of low acute oral toxicity with LD50 values in excess 5000 mg/kg bw in the rat and mouse and greater than 800 mg/kg bw in the dog.

Tylosin price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1703805 Tylosin, predominantly Tylosin A 1401-69-0 250mg $371 2021-03-22 Buy
Cayman Chemical 22599 Tylosin ≥98% (mixture of tylosins) 1401-69-0 10mg $35 2021-03-22 Buy
Cayman Chemical 22599 Tylosin ≥98% (mixture of tylosins) 1401-69-0 50mg $158 2021-03-22 Buy
Cayman Chemical 22599 Tylosin ≥98% (mixture of tylosins) 1401-69-0 100mg $228 2021-03-22 Buy

Tylosin Chemical Properties,Uses,Production

Description

Occupational exposure concerns farmers, breeders, animal-feed workers and veterinarians.

Chemical Properties

Off-White to Pale Yellow Solid.
Tylosin is a macrolide antibiotic which is active against certain Gram-positive and Gram-negative bacteria and Gram-positive mycoplasmas. It consists predominantly of tylosin(factor A), but varying amounts of desmycosin (factor B), macrocin (factor C) and relomycin(factor D) may also be present, depending on the manufacturing source. Most of themicrobiological activity resides with tylosin factor A.
Tylosin
Tylosin is a weak organic base with a high degree of lipid solubility, thus it is well distributed to the organs and tissues of animals (Burrows, 1980).
Tylosin is used in pigs, cattle and poultryfor the treatment of conditions caused by sensitive organisms. It may be administered by oral orparenteral routes. Tylosin is not used in human medicine.

Uses

paramagnetic agent

Uses

Tylosin is a 16-membered macrocyclic lactone isolated from Streptomyces fradiae in 1961. Tylosin has broad spectrum antibacterial activity and was developed as a veterinary pharmaceutical for treatment of bacterial infections in a range of domestic animals . Tylosin acts by binding to the 50S ribosomal subunit resulting in the inhibition of protein synthesis in bacteria.

Uses

Macrolide antibiotic isolated from a strain of Streptomycetes fradiae found in soil from Thailand. Antibacterial.

Definition

ChEBI: A macrolide antibiotic that is tylonolide having mono- and diglycosyl moieties attached to two of its hydroxy groups. It is found naturally as a fermentation product of Streptomyces fradiae.

Indications

In cattle, tylosin is used for treatment of BRD caused by Mannheimia, Pasteurella multocida, and Histophilus somni (formerly Haemophilus somnus). It is used for interdigital necrobacillosis (foot rot) in cattle caused by Fusobacterium necrophorum or Bacteroides melaninogenicus. In pigs, it is used for treatment of swine arthritis caused by Mycoplasma hyosynoviae, swine pneumonia caused by Pasteurella spp., swine erysipelas caused by Erysipelothrix rhusiopathiae, swine dysentery associated with Serpulina (Treponema) hyodysenteriae, and proliferative enteropathy caused by L. intracellularis. For treatment in pigs, it is also added to feed (Type A–medicated feed article) or drinking water. In small animals, it is used for gram-positive soft tissue and skin infections. However, the most common use in dogs is for treatment of diarrhea, referred to as antibiotic-responsive diarrhea, that has not responded to other treatments. The etiology of the diarrhea is not known but may be caused by Clostridium or Camphylobacter. For this use, the powdered formulation (swine formulation) is most often added to food daily for maintenance.

brand name

Tylan (Lilly).

Contact allergens

Tylosin is a macrolid antibiotic used in veterinary medicine. Occupational exposure concerns farmers, breeders, animal feed workers, and veterinarians.

Mechanism of action

Tylosin is a 16-membered macrolide approved for therapy of a variety of infections in pigs, cattle, dogs, and poultry (see indications below). It is formulated as tylosin tartrate or tylosin phosphate. Like other macrolide antibiotics, tylosin inhibits bacteria by binding to the 50S ribosome and inhibiting protein synthesis. Spectrum of activity is limited primarily to gram-positive aerobic bacteria. Clostridium and Campylobacter are usually sensitive. The spectrum also includes the bacteria that cause BRD. Escherichia coli and Salmonella are resistant. In pigs, Lawsonia intracellularis is sensitive.

Side effects

Tylosin may cause diarrhea in some animals. However, oral treatment for colitis in dogs has been administered for several months with safety. Skin reactions have been observed in pigs. Oral administration to horses has been fatal.

Safety Profile

Poison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx. See also TnOSIN HYDROCHLORIDE.

Veterinary Drugs and Treatments

Although the injectable form of tylosin is approved for use in dogs and cats, it is rarely used parenterally in those species. Oral tylosin is sometimes recommended for the treatment of chronic colitis in small animals (see Doses), but controlled studies documenting its efficacy have not been performed.
Tylosin is also used clinically in cattle and swine for infections caused by susceptible organisms.

Solubility in organics

soluble in lower alcohols, esters, ketones,chlorinated hydrocarbons, benzene, ether, chloroform.

Tylosin Preparation Products And Raw materials

Raw materials

Preparation Products


Tylosin Suppliers

Global( 184)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 21032 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 567 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29961 58
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 297 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5450 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19753 58
Shanghai Longyu Biotechnology Co., Ltd.
+8615821988213
info@longyupharma.com CHINA 2462 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58

View Lastest Price from Tylosin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-21 Tylosin
1401-69-0
US $10.00-150.00 / KG 0.5KG >99% 20tons Anhui Rencheng Technology Co., Ltd
2021-10-20 Tylosin
1401-69-0
US $100.00 / KG 1KG 99% 9000kg/per week Hebei Lingding Biological Technology Co., Ltd
2021-10-08 Tylosin
1401-69-0
US $0.00 / KG 1g 99% 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD

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