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Description Drug Instructions Side effects of dipyrone Uses Hazards & Safety Information References
Chemical Name:
Molecular Formula:
Formula Weight:
MOL File:

Dipyrone Properties

storage temp. 
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
68-89-3(CAS DataBase Reference)
NIST Chemistry Reference


Hazard Codes  Xn
Risk Statements  42/43
Safety Statements  36
WGK Germany  2
RTECS  PB1300000
HS Code  29331920

Dipyrone price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 15771 Metamizole (sodium salt) ≥98% 68-89-3 25g $38 2018-11-13 Buy
Cayman Chemical 15771 Metamizole (sodium salt) ≥98% 68-89-3 50g $69 2018-11-13 Buy

Dipyrone Chemical Properties,Uses,Production


Dipyrone is a water soluble pyrazolone derivative available in oral, rectal and injectable forms. It has analgesic, antipyretic, antispasmodic, and anti-inflammatory properties. Dipyrone is used most commonly to treat severe pain, particularly, for pain associated with smooth muscle spasm or colic affecting the gastrointestinal, biliary or urinary tracts. It is useful for fever that is refractory to other treatment. Because of the risk of serious adverse effects, such as agranulocytosis, its use is justified only in serious situations where no alternative is available or suitable.

Drug Instructions

Alias: dipyrone, NOVALGIN; Noramidopyrine, Metamizole sodium,metamizole
Property: This product is white or yellow-white crystal or crystalline powder, odorless, slightly bitter taste, soluble in water.
Action: Dipyrone is the derivative of aminopyrine, its has a significant effect of antipyretic analgesia. The antipyretic effect of it is three times as aminopyrine, the analgesic effect is similar to that of aminopyrine.
Process vivo: Easily absorbed orally, mainly metabolized by the liver and excreted of renal
Indications: It is mainly used for cooling, acute arthritis, headache, rheumatic neuralgia, toothache and muscle pain etc.

Oral or intranasal administration. For oral, the adult should take 0.5g of the medicine and three times a day, the amount of the child is 8-10mg/ kg, the number of the times is according to the necessary. For intranasal, the child under 5 years old can take 1-2drops for each nostril, can take the medicine another time if necessary,for the patient above 5 years old increase the dosage appropriately.
1, The dosage should be controled strictly to prevent collapse.
2, The intramuscular injection can cause atrophy and erosion to the local muscle, it is abandoned now.
3, The patient who has a allergy to the praziquantel can not use the dipyrone
4, It not suitable for a long-term application, Please pay attention to the granulocytes.

Tablets:each table is weight for 0.25g or 0.5g; Injection: each ingection has the specification of 0.25g/1ml or 0.5g/2ml; Drops: solution with the concentration of 10%~20%

Side effects of dipyrone

1, The side effects contain the allergies, exhaustion, leukopenia, thrombocytopenia even the severe aplastic anemia.
2, Some people may also suffering the nephrotoxicity and gastrointestinal bleeding after they take the dipyrone.The most serious side effect is lethal agranulocytosis.


It has the effect of detoxification, analgesic and anti-rheumatic etc and mainly used for cooling, but also can be applied to cure the acute arthritis, rheumatic pain, muscle pain and headache etc.

Hazards & Safety Information

Toxic Chemicals
Acute toxicity
For oral – the lethal dose for rat LD50: 3000 mg/kg;
For oral – the lethal dose for mouse LD50: 2891 mg/kg
Toxicity grading
Moderately toxic
Flammability hazard characteristic
It is combustible and can produce the toxic fumes contained nitrogen oxides, sulfur oxides and sodium oxide during the combustion
Storage Characteristic
The storeroom should be airy, low-temperature and dried.
Extinguishing agent
Dry powder, foam, sand, carbon dioxide, water mist


[1] Micha Levy, Ester Zylber-Katz and Bernd Rosenkranz, Clinical Pharmacokinetics of Dipyrone and its Metabolites, Clinical Pharmacokinetics, 1995, vol. 28, 216-234
[2] JE Edwards, F. Meseguer, CC Faura, RA Moore and HJ McQuay, Single-dose dipyrone for acute postoperative pain, Cochrane Database Syst Rev., 2010, vol. 9, CD003227

Chemical Properties



A non-steroidal anti-inflammatory drug that, when coadministered with morphine, potentiates its antinociceptive action and delays the development of tolerance. Dipyrone is a relatively selective inhibitor of cyclooxygenase-3 (COX-3), with lower activity against COX-1 and no activity against COX-2. Blocks PGE2-induced hyperalgesia in several models.


Dipyrone is a non-steroidal anti-inflammatory drug that, when coadministered with morphine, potentiates its antinociceptive action and delays the development of tolerance. Dipyrone is a relatively sel ective inhibitor of cyclooxygenase-3 (COX-3), with lower activity against COX-1 and no activity against COX-2. Dipyrone blocks PGE2-induced hyperalgesia in several models.


ChEBI: An organic sodium salt of antipyrine substituted at C-4 by a methyl(sulfonatomethyl)amino group, commonly used as a powerful analgesic and antipyretic.

brand name

Diprofarn (Farmitalia, Societa Farmaceutici Italia, Italy); Novaldin (Sterling Winthrop).

Safety Profile

Poison by subcutaneous route. Moderately toxic by several other routes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. Questionable carcinogen with experimental neoplastigenic data. See also SULFONATES. When heated to decomposition it emits very toxic fumes of NOx,, Na2O, and SOx,.

Dipyrone Preparation Products And Raw materials

Raw materials

Preparation Products

Dipyrone Suppliers

Global( 170)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hebei Guanlang Biotechnology Co., Ltd.
+86-0311-66562153 whatsapp +8615203118427
+86-0311-66562153 CHINA 417 50
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 CHINA 3217 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 22058 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20795 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32763 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 CHINA 552 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 CHINA 893 55
Wuhan Fortuna Chemical Co., Ltd +86-27-59207852 85767163
+86-27-59524646 China 3092 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933; China 96815 76

View Lastest Price from Dipyrone manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-09-26 Novalgin,Metamizole sodium,Dipyrone cas 68-89-3
US $10.00 / G 10G 99% 10mt Hubei XinRunde Chemical Co., Ltd.

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