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Dipyrone

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Products Intro: Product Name:Dipyrone
CAS:68-89-3
Purity:99% Package:Packaging(Various Packaging) Remarks:email: sales@crovellbio.com whatsapp/wechat: +8615203118427 skype: sales@crovellbio.com
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Products Intro: Product Name:Analgin
CAS:68-89-3
Purity:99% Package:52/KG
Company Name: Henan DaKen Chemical CO.,LTD.
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Products Intro: Product Name:Dipyrone
CAS:68-89-3
Purity:99% Package:100g,500g,1kg,5kg,10kg
Company Name: Henan Tianfu Chemical Co.,Ltd.
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Products Intro: CAS:68-89-3
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Mainchem Co., Ltd.
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Products Intro: Product Name:Sodium [(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methanesulfonate
CAS:68-89-3

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Dipyrone Basic information
Description Drug Instructions Side effects of dipyrone Uses Hazards & Safety Information References
Product Name:Dipyrone
Synonyms:1-phenyl-2,3-dimethyl-4-methylamino-5-pyrazolon-n-methanesulfonsaeurennatriu;1-phenyl-2,3-dimethyl-5-pyrazolone-4-methylaminomethanesulfonatesodium;1-phenyl-2,3-dimethylpyrazolone-(5)-4-methylaminomethanesulfonicacidsodium;4-methylamino-1,5-dimethyl-2-phenyl-3-pyrazolonesodiummethanesulfonate;4-sodiummethanesulfonatemethylamine-antipyrine;alginodia;[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-N-methylamino] methanesulphonate;Dipyrone Hcl / Analgin
CAS:68-89-3
MF:C13H16N3NaO4S
MW:333.34
EINECS:200-694-7
Product Categories:PHARMACEUTICALS;DIO - DIZForensic and Veterinary Standards;Alphabetic;D;Drugs&Metabolites;Neat Compounds;Cosmetic Ingredients & Chemicals;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Sulfur & Selenium Compounds
Mol File:68-89-3.mol
Dipyrone Structure
Dipyrone Chemical Properties
storage temp. 2-8°C
Stability:Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference68-89-3(CAS DataBase Reference)
NIST Chemistry ReferenceDipyrone(68-89-3)
Safety Information
Hazard Codes Xn
Risk Statements 42/43
Safety Statements 36
WGK Germany 2
RTECS PB1300000
HS Code 29331920
MSDS Information
ProviderLanguage
SigmaAldrich English
Dipyrone Usage And Synthesis
DescriptionDipyrone is a water soluble pyrazolone derivative available in oral, rectal and injectable forms. It has analgesic, antipyretic, antispasmodic, and anti-inflammatory properties. Dipyrone is used most commonly to treat severe pain, particularly, for pain associated with smooth muscle spasm or colic affecting the gastrointestinal, biliary or urinary tracts. It is useful for fever that is refractory to other treatment. Because of the risk of serious adverse effects, such as agranulocytosis, its use is justified only in serious situations where no alternative is available or suitable.
Drug InstructionsAlias: dipyrone, NOVALGIN; Noramidopyrine, Metamizole sodium,metamizole
Property: This product is white or yellow-white crystal or crystalline powder, odorless, slightly bitter taste, soluble in water.
Action: Dipyrone is the derivative of aminopyrine, its has a significant effect of antipyretic analgesia. The antipyretic effect of it is three times as aminopyrine, the analgesic effect is similar to that of aminopyrine.
Process vivo: Easily absorbed orally, mainly metabolized by the liver and excreted of renal
Indications: It is mainly used for cooling, acute arthritis, headache, rheumatic neuralgia, toothache and muscle pain etc.

Dosage
Oral or intranasal administration. For oral, the adult should take 0.5g of the medicine and three times a day, the amount of the child is 8-10mg/ kg, the number of the times is according to the necessary. For intranasal, the child under 5 years old can take 1-2drops for each nostril, can take the medicine another time if necessary,for the patient above 5 years old increase the dosage appropriately.
Note
1, The dosage should be controled strictly to prevent collapse.
2, The intramuscular injection can cause atrophy and erosion to the local muscle, it is abandoned now.
3, The patient who has a allergy to the praziquantel can not use the dipyrone
4, It not suitable for a long-term application, Please pay attention to the granulocytes.

Specification
Tablets:each table is weight for 0.25g or 0.5g; Injection: each ingection has the specification of 0.25g/1ml or 0.5g/2ml; Drops: solution with the concentration of 10%~20%
Side effects of dipyrone1, The side effects contain the allergies, exhaustion, leukopenia, thrombocytopenia even the severe aplastic anemia.
2, Some people may also suffering the nephrotoxicity and gastrointestinal bleeding after they take the dipyrone.The most serious side effect is lethal agranulocytosis.
UsesIt has the effect of detoxification, analgesic and anti-rheumatic etc and mainly used for cooling, but also can be applied to cure the acute arthritis, rheumatic pain, muscle pain and headache etc.
Hazards & Safety InformationCategory
Toxic Chemicals
Acute toxicity
For oral – the lethal dose for rat LD50: 3000 mg/kg;
For oral – the lethal dose for mouse LD50: 2891 mg/kg
Toxicity grading
Moderately toxic
Flammability hazard characteristic
It is combustible and can produce the toxic fumes contained nitrogen oxides, sulfur oxides and sodium oxide during the combustion
Storage Characteristic
The storeroom should be airy, low-temperature and dried.
Extinguishing agent
Dry powder, foam, sand, carbon dioxide, water mist
References[1] Micha Levy, Ester Zylber-Katz and Bernd Rosenkranz, Clinical Pharmacokinetics of Dipyrone and its Metabolites, Clinical Pharmacokinetics, 1995, vol. 28, 216-234
[2] JE Edwards, F. Meseguer, CC Faura, RA Moore and HJ McQuay, Single-dose dipyrone for acute postoperative pain, Cochrane Database Syst Rev., 2010, vol. 9, CD003227
Chemical Propertiessolid
UsesA non-steroidal anti-inflammatory drug that, when coadministered with morphine, potentiates its antinociceptive action and delays the development of tolerance. Dipyrone is a relatively selective inhibitor of cyclooxygenase-3 (COX-3), with lower activity against COX-1 and no activity against COX-2. Blocks PGE2-induced hyperalgesia in several models.
UsesDipyrone is a non-steroidal anti-inflammatory drug that, when coadministered with morphine, potentiates its antinociceptive action and delays the development of tolerance. Dipyrone is a relatively sel ective inhibitor of cyclooxygenase-3 (COX-3), with lower activity against COX-1 and no activity against COX-2. Dipyrone blocks PGE2-induced hyperalgesia in several models.
DefinitionChEBI: An organic sodium salt of antipyrine substituted at C-4 by a methyl(sulfonatomethyl)amino group, commonly used as a powerful analgesic and antipyretic.
Brand nameDiprofarn (Farmitalia, Societa Farmaceutici Italia, Italy); Novaldin (Sterling Winthrop).
Safety ProfilePoison by subcutaneous route. Moderately toxic by several other routes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. Questionable carcinogen with experimental neoplastigenic data. See also SULFONATES. When heated to decomposition it emits very toxic fumes of NOx,, Na2O, and SOx,.
Dipyrone Preparation Products And Raw materials
Raw materialsSodium bisulfite
Tag:Dipyrone(68-89-3) Related Product Information
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