Alvespimycin
- CAS No.
- 467214-20-6
- Chemical Name:
- Alvespimycin
- Synonyms
- 17-DMAG;17-[2-(Dimethylamino)ethylamino]-17-desmethylgeldanamycin;17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin;DMAG-d6;CS-2382;17-DMAG-d6;spiromycin;17-DMAG HCI;Alvespimycin;NSC 707545-d6
- CBNumber:
- CB7972636
- Molecular Formula:
- C32H48N4O8
- Molecular Weight:
- 616.75
- MDL Number:
- MFCD08457919
- MOL File:
- 467214-20-6.mol
- MSDS File:
- SDS
| Melting point | >270°C (dec.) |
|---|---|
| Boiling point | 810.5±65.0 °C(Predicted) |
| Density | 1.20 |
| storage temp. | Desiccate at -20°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 8.48±0.70(Predicted) |
| color | Very Dark Purple |
| FDA UNII | 001L2FE0M3 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P271-P280 |
| HS Code | 29419090 |
Alvespimycin price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 11036 | 17-DMAG ≥98% | 467214-20-6 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 11036 | 17-DMAG ≥98% | 467214-20-6 | 5mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 11036 | 17-DMAG ≥98% | 467214-20-6 | 10mg | $195 | 2024-03-01 | Buy |
| Tocris | 2610 | 17-DMAGhydrochloride ≥99%(HPLC) | 467214-20-6 | 1 | $255 | 2021-12-16 | Buy |
| Usbiological | 207011 | 17-DMAG | 467214-20-6 | 100ug | $273 | 2021-12-16 | Buy |
Alvespimycin Chemical Properties,Uses,Production
Description
Geldanamycin is a potent inhibitor of Hsp90 that has poor water solubility. 17-
Chemical Properties
Solid
Uses
17-DMAG is a synthetic Geldanamycin derivative and inhibitor of Hsp90.
Uses
The labelled derivative of the analogue of Gelamycin (G304500) and 17-(Allylamino)geldanamycin (A549650). It acts as a Hsp90 inhibitor and displays more potent antitumor activity than 17-AAG.
Uses
17-DMAG is an analogue of Gelamycin (G304500) and 17-(Allylamino)geldanamycin (A549650). 17-DMAG acts as a Hsp90 inhibitor and displays more potent antitumor activity than 17-AAG.
Definition
ChEBI: A 19-membered macrocyle that is geldanamycin in which the methoxy group attached to the benzoquinone moiety has been replaced by a 2-(N,N-dimethylamino)ethylamino group.
Biological Activity
Water-soluble analog of 17-AAG (17-Demethoxy-17-(2-propenylamino)geldanamycin ) and geldanamycin (9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-carbamate ). Binds the ATP binding site of Hsp90 and inhibits its chaperone activity. Displays more potent antitumor activity than 17-AAG (mean GI 50 values are 53 and 123 nM for 17-DMAG and 17-AAG respectively).
Alvespimycin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 1000 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9334 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
View Lastest Price from Alvespimycin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-12 | Alvespimycin
467214-20-6
|
US $0.00 / kg | 1kg | 99% | 2000ton | Shaanxi Haibo Biotechnology Co., Ltd | |
 |
2023-04-20 | Alvespimycin
467214-20-6
|
US $50.00 / kg | 1kg | 99% | 50 tons | Hebei Duling International Trade Co. LTD | |
 |
2021-07-13 | Alvespimycin
467214-20-6
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Alvespimycin
467214-20-6
- US $0.00 / kg
- 99%
- Shaanxi Haibo Biotechnology Co., Ltd
-
- Alvespimycin
467214-20-6
- US $50.00 / kg
- 99%
- Hebei Duling International Trade Co. LTD
-
- Alvespimycin
467214-20-6
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd