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4,4'-Diphenylmethane diisocyanate

4,4'-Diphenylmethane diisocyanate
4,4'-Diphenylmethane diisocyanate structure
Chemical Name:
4,4'-Diphenylmethane diisocyanate
Molecular Formula:
Formula Weight:
MOL File:

4,4'-Diphenylmethane diisocyanate Properties

Melting point:
38-44 °C
Boiling point:
392 °C
vapor pressure 
0.066 hPa (20 °C)
refractive index 
1.5906 (estimate)
Flash point:
196 °C
storage temp. 
2g/l (decomposition)
Specific Gravity
explosive limit
Water Solubility 
Moisture Sensitive/Lachrymatory
Exposure limits
TLV-TWA 0.051 mg/m3 (0.005 ppm) (ACGIH and NIOSH); ceiling (air) 0.204 mg/m3 (0.02 ppm)/10 min (NIOSH and OSHA); IDLH 102 mg/m3 (10 ppm).
Stable. Combustible. Incompatible with strong oxidizing agents. Reacts violently with alcohols.
CAS DataBase Reference
101-68-8(CAS DataBase Reference)
NIST Chemistry Reference
Benzene, 1,1'-methylenebis[4-isocyanato-(101-68-8)
EPA Substance Registry System
Benzene, 1,1'-methylenebis[4-isocyanato- (101-68-8)
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H330-H370-H372-H315-H317-H319-H332-H334-H335-H351-H373
Precautionary statements  P261-P280-P284-P304+P340+P312-P305+P351+P338-P342+P311-P280h-P310-P260-P304+P340-P201-P202-P264-P270-P271-P272-P302+P352+P333+P313+P363-P304+P340+P310-P305+P351+P338+P337+P313-P307+P311-P403+P233-P405-P501
Hazard Codes  Xn,T,C
Risk Statements  42/43-36/37/38-20-48/20-40
Safety Statements  45-36/37-23
RIDADR  2206
WGK Germany  1
RTECS  NQ9350000
Autoignition Temperature >600 °C
Hazard Note  Toxic/Corrosive/Lachrymatory/Moisture Sensitive
HazardClass  6.1
PackingGroup  II
HS Code  29291090
Toxicity LD50 orally in Rabbit: > 5000 mg/kg LD50 dermal Rabbit > 9000 mg/kg

4,4'-Diphenylmethane diisocyanate price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 256439 4,4′-Methylenebis(phenyl isocyanate) 98% 101-68-8 50g $41.2 2018-11-13 Buy
Sigma-Aldrich 256439 4,4′-Methylenebis(phenyl isocyanate) 98% 101-68-8 5kg $438 2018-11-13 Buy
TCI Chemical D0897 Methylenediphenyl 4,4'-Diisocyanate >97.0%(T) 101-68-8 25g $23 2018-11-22 Buy
TCI Chemical D0897 Methylenediphenyl 4,4'-Diisocyanate >97.0%(T) 101-68-8 500g $46 2018-11-22 Buy
Alfa Aesar L15740 4,4'-Methylenebis(phenyl isocyanate), 98% 101-68-8 100g $29.6 2018-11-13 Buy

4,4'-Diphenylmethane diisocyanate Chemical Properties,Uses,Production

Chemical Properties

white to light yellow flakes or crystals

Chemical Properties

MDI is a white to light-yellow, odorless flakes. A liquid above 37C.


Diphenylmethane-4,4-diisocyanate (MDI)is widely used in the production ofrigid urethane foam products, coatings, andelastomers..


Diphenyl methane diisocyanate (MDI) is widely used in polyurethane coatings, this product is made of polyurethane foam used as a warm (cold), building materials, vehicle, ship parts; masterwork can made car Block, buffer, synthetic leather, non plastic polyurethane, polyurethane elastic fiber, no plastic elastic fibers, films, adhesives.


ChEBI: A diisocyanate consisting of diphenylmethane with two isocyanate groups at the 4- and 4'-positions.

General Description

Diphenylmethane-4,4-diisocyanate is a light yellow colored solid. 4,4'-Diphenylmethane diisocyanate is not soluble in water. 4,4'-Diphenylmethane diisocyanate may be toxic by ingestion, inhalation, or skin absorption. If in a solution 4,4'-Diphenylmethane diisocyanate may or may not burn depending on the nature of the material and/or the solvent. It's used to make plastics.

Air & Water Reactions

4,4'-Diphenylmethane diisocyanate is not soluble in water.

Reactivity Profile

Isocyanates and thioisocyanates, such as 4,4'-Diphenylmethane diisocyanate, are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents. Such reactions in the absence of solvents often occur with explosive violence, [Wischmeyer(1969)].

Health Hazard

Breathlessness, chest discomfort, and reduced pulmonary function.

Health Hazard

MDI can present a moderate to severe healthhazard, because of respiration of its vapors and particulates. It can contaminate the environment during foam application; concentrations in air were measured as high as5 mg/m3, mostly as particulates (ACGIH1986).
The toxic route is primarily inhalation.The vapor pressure of this compound atambient temperature is very low, 0.00014torr at 25°C. However, when heated to about75°C, the acute health hazard is greatlyenhanced (Hadengue and Philbert 1983). Theacute toxic symptoms were found to besimilar to those of toluene-2,4-diisocyanateand other aromatic isocyanates. Inhalation ofits vapors or particulates can cause bronchitis, coughing, fever, and an asthma-likesyndrome. Other symptoms were nausea,shortness of breath, chest pain, insomnia,and irritation of the eyes, nose, and throat.The immunologic response, however, variedamong humans. Exposure to 0.1–0.2 ppmfor 30 minutes is likely to manifest the acutetoxic effects in humans.
MDI is an eye and skin irritant. Contactwith skin can produce eczema. The acuteoral toxicity of this compound is very low,considerably lower than that of toluene-2,4-diisocyanate. The lethal dose for rats was31.7 g/kg.
MDI showed positive in mutagenic testingon Salmonella typhimurium. There is noreport that indicates its carcinogenicity.

Fire Hazard

Noncombustible; flash point (open cup) 202°C (395°F). MDI reactions with strong oxidizers, acids, and bases can be vigorous.

Contact allergens

MDI is used in the manufacture of various polyurethane products: elastic and rigid foams, paints, lacquers, adhesives, binding agents, synthetic rubbers, and elastomeric fibers.

Safety Profile

Poison by inhalation. Mildly toxic by ingestion. Human systemic effects by inhalation: increased immune response and body temperature. A skin and eye irritant. An allergic sensitizer. Questionable carcinogen. Mutation data reported. A flammable liquid. When heated to decomposition it emits toxic fumes of NOx and SOx.

Potential Exposure

MDI is used in the production of polyurethane foams and plastics; polyurethane coatings; elastomers, and thermoplastic resins.


UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required


May form explosive mixture with air. Isocyanates are highly flammable and reactive with many compounds, even with themselves. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Reaction with moist air, water or alcohols may form amines and insoluble polyureas and react exothermically, releasing toxic, corrosive or flammable gases, including carbon dioxide; and, at the same time, may generate a violent release of heat increasing the concentration of fumes in the air. Incompatible with amines, aldehydes, alkali metals, ammonia, carboxylic acids, caprolactum, alkaline materials, glycols, ketones, mercaptans, hydrides, organotin catalysts, phenols, strong acids, strong bases, strong reducing agents such as hydrides, urethanes, ureas. Elevated temperatures or contact with acids, bases, tertiary amines, and acylchlorides may cause explosive polymerization. Attacks some plastics, rubber and coatings. May accumulate static electrical charges, and may cause ignition of its vapors. Unstable above 100F/38C. Polymerizes at temperatures above 204C. Contact with metals may evolve flammable hydrogen gas.

Waste Disposal

Controlled incineration (oxides of nitrogen are removed from the effluent gas by scrubbers and/or thermal devices).

4,4'-Diphenylmethane diisocyanate Preparation Products And Raw materials

Raw materials

Preparation Products

4,4'-Diphenylmethane diisocyanate Suppliers

Global( 124)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32447 55
career henan chemical co
+86-371-86658258 CHINA 30001 58
+86 18953170293
+86 0531-67809011 CHINA 2995 58
Chemwill Asia Co.,Ltd.
86-21-51861608;;; CHINA 23980 58
Hubei Jusheng Technology Co.,Ltd.
027-59599243 CHINA 28236 58
Zhonglan Industry Co., Ltd.
(86) 531-82956570
(86) 531-82956571 CHINA 207 58
Hubei xin bonus chemical co. LTD
027-59338440 CHINA 23049 58
Chongqing Chemdad Co., Ltd
+86-13650506873 CHINA 35440 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 021-20337333/400-620-6333
021-50323701 China 24986 65
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
86-10-82849933; China 96815 76

View Lastest Price from 4,4'-Diphenylmethane diisocyanate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-11 4,4'-Diphenylmethane diisocyanate
US $1.00 / KG 1KG 99% 25kg career henan chemical co

4,4'-Diphenylmethane diisocyanate Spectrum

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