Danusertib
- CAS No.
- 827318-97-8
- Chemical Name:
- Danusertib
- Synonyms
- CS-1856;CS-1969;PHA-739358;danusertib;Unii-m3X659D0fy;Danusertib USP/EP/BP;Danusertib(PHA-739358);PHA-739358(Danusertib);PHA-739358 Danusertib PHA739358;PHA-739358; PHA739358; PHA 739358
- CBNumber:
- CB81518500
- Molecular Formula:
- C26H30N6O3
- Molecular Weight:
- 474.55
- MDL Number:
- MFCD12024692
- MOL File:
- 827318-97-8.mol
- MSDS File:
- SDS
Melting point | >145°C (dec.) |
---|---|
Boiling point | 664.1±55.0 °C(Predicted) |
Density | 1.322 |
storage temp. | Refrigerator |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
pka | 13.70±0.20(Predicted) |
color | Pale Beige |
NCI Dictionary of Cancer Terms | PHA-739358 |
FDA UNII | M3X659D0FY |
NCI Drug Dictionary | danusertib |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H302-H315-H319-H335 | |||||||||
Precautionary statements | P261-P305+P351+P338 | |||||||||
NFPA 704 |
|
Danusertib price More Price(37)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 18387 | Danusertib ≥95% | 827318-97-8 | 1mg | $44 | 2024-03-01 | Buy |
Cayman Chemical | 18387 | Danusertib ≥95% | 827318-97-8 | 5mg | $193 | 2024-03-01 | Buy |
Cayman Chemical | 18387 | Danusertib ≥95% | 827318-97-8 | 10mg | $341 | 2024-03-01 | Buy |
Cayman Chemical | 18387 | Danusertib ≥95% | 827318-97-8 | 50mg | $1148 | 2024-03-01 | Buy |
Usbiological | 474091 | Danusertib | 827318-97-8 | 100mg | $1932 | 2021-12-16 | Buy |
Danusertib Chemical Properties,Uses,Production
Uses
An Aurora kinase inhibitor, used to treat patients with chromic myeloid leukemia. It is a COVID19-related research product.
Uses
Danusertib is an Aurora kinase inhibitor, used to treat patients with chromic myeloid leukemia.
Definition
ChEBI: N-[5-[(2R)-2-methoxy-1-oxo-2-phenylethyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methyl-1-piperazinyl)benzamide is a member of piperazines.
Biological Activity
danusertib (previously known as pha-739358), a 3-aminopyrazole derivative identified during the development of the pyrrolopyrazole sub-series, is a potent small-molecule inhibitor of aurora kinases family members with a dominant inhibition for aurora b kinase (abk). this pan-aurora kinases inhibitor is also able to inhibit several tyrosine kinases, including t315i mutant, ret, trk-a and fibroblast growth factor receptor-1 (fgfr-1), which are involved in multiple malignancies, such as chronic myelogenous leukemia (cml), acute lymphoblastic leukemia (all), thyroid prostate and breast carcinoma. thus, in many previous studies, danusertib exhibits remarkable antitumor activity in a number of different xengorafts, spontaneous, and transgenic animal tumor models with a favorable pharmacokinetic and safety profile.carpinelli p, ceruti r, giorgini ml, cappella p, gianellini l, croci v, degrassi a, texido g, rocchetti m, vianello p, rusconi l, storici p, zugnoni p, arrigoni c, soncini c, alli c, patton v, marsiglio a, ballinari d, pesenti e, fancelli d, moll j. pha-739358, a potent inhibitor of aurora kinases with a selecyive target inhibiton profile relevant to cancer. mol cancer ther 2007; 6(12 pt 1): 3158-3168
target
Aurora A/B/C
Danusertib Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 24099 | 58 |
Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9640 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |