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2-METHOXYMETHYL METHANSULFONATE

2-METHOXYMETHYL METHANSULFONATE Structure
2-METHOXYMETHYL METHANSULFONATE structure
CAS No.
16427-44-4
Chemical Name:
2-METHOXYMETHYL METHANSULFONATE
Synonyms
2-Methoxymethyl Methansulfonate;2-METHOXYETHYL METHANESULFONATE;2-MethoxyethylMethanesulfonate>Ethanol, 2-methoxy-, 1-methanesulfonate;METHANESULFONIC ACID 2-METHOXYETHYL ESTER
CBNumber:
CB8162926
Molecular Formula:
C4H10O4S
Molecular Weight:
154.18
MDL Number:
MFCD02656401
MOL File:
16427-44-4.mol
Last updated:2025-07-24 18:13:45
Product description Number Pack Size Price
2-Methoxyethyl Methanesulfonate >97.0%(GC) M1446 5g $104
2-Methoxyethyl Methanesulfonate >97.0%(GC) M1446 25g $301
2-MethoxymethylMethansulfonate M226180 25g $165
2-Methoxyethyl methanesulfonate 95+% 096202 10g $168
2-Methoxyethyl Methanesulfonate 8345AA 25g $370
More product size
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2-METHOXYMETHYL METHANSULFONATE Properties

Boiling point 126 °C / 12mmHg
Density 1.25
refractive index 1.4300-1.4340
storage temp. Sealed in dry,Room Temperature
form clear liquid
color Colorless to Light yellow to Light orange

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338
Risk Statements  36/37/38
Safety Statements  26-36/37/39
HS Code  2909199090

2-METHOXYMETHYL METHANSULFONATE price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical M1446 2-Methoxyethyl Methanesulfonate >97.0%(GC) 16427-44-4 5g $104 2025-07-31 Buy
TCI Chemical M1446 2-Methoxyethyl Methanesulfonate >97.0%(GC) 16427-44-4 25g $301 2025-07-31 Buy
TRC M226180 2-MethoxymethylMethansulfonate 16427-44-4 25g $165 2021-12-16 Buy
Matrix Scientific 096202 2-Methoxyethyl methanesulfonate 95+% 16427-44-4 10g $168 2021-12-16 Buy
AK Scientific 8345AA 2-Methoxyethyl Methanesulfonate 16427-44-4 25g $370 2021-12-16 Buy
Product number Packaging Price Buy
M1446 5g $104 Buy
M1446 25g $301 Buy
M226180 25g $165 Buy
096202 10g $168 Buy
8345AA 25g $370 Buy

2-METHOXYMETHYL METHANSULFONATE Chemical Properties,Uses,Production

Uses

2-Methoxymethyl Methansulfonate is used in the ring-opening polymerization of lactide. Also used in the synthesis of acetylcholine receptor ligands.

Synthesis

2-Methoxyethanol

109-86-4

Methanesulfonyl chloride

124-63-0

2-METHOXYMETHYL METHANSULFONATE

16427-44-4

GENERAL STEPS: To a cooled solution of 2-methoxyethanol (0.8 mL) in dichloromethane (50 mL) at 0°C, methylsulfonyl chloride (1.3 mL) and triethylamine (2 mL) were added slowly and dropwise. After 5 minutes of reaction, the ice bath was removed and the reaction mixture was gradually warmed to room temperature with continuous stirring for 1 hour. Upon completion of the reaction, the reaction mixture was washed sequentially with 1.0 N NaOH solution and saturated saline, followed by drying with anhydrous magnesium sulfate and concentration under reduced pressure to give 2-methoxyethyl methane sulfonate as an oil in quantitative yield. Mass spectrum (ESI+) m/z 155.1 ([M+H]+), molecular formula C4H10O4S. 2-Methoxyethyl methane sulfonate (1.54 g) was dissolved in 2-butanone (150 mL) and cesium carbonate (6.50 g) and 3-fluoro-4-nitrophenol (1.52 g) were added. The reaction mixture was refluxed for 19 h. After cooling, it was filtered, concentrated under reduced pressure and purified by silica gel column chromatography (eluent: ethyl acetate/heptane) to give the target product in 98% yield.1H NMR (400 MHz, DMSO-d6) δ 7.95, 6.82, 6.67, 4.25, 3.92, 3.68, 3.33, 3.31. 2-Methoxy-4-(2-methoxyethoxy)-1-nitrobenzene (2.0 g) was dissolved in methanol (200 mL) and 10% Pd/C (1.0 g) and HCl (1.8 g) were added. The reaction was shaken at 40 psi hydrogen pressure for 15 minutes. After completion of the reaction, the reaction mixture was filtered and the filtrate was crystallized by ethanol/ether to give 2-methoxy-4-(2-methoxyethoxy)aniline hydrochloride in 76% yield. Mass spectrum (ESI+) m/z 198.1 ([M+H]+), molecular formula C10H15NO3. Example 156 was prepared from 2-methoxy-4-(2-methoxyethoxy)aniline hydrochloride and 2-isocyanato-5-(trifluoromethyl)-1,3,4-thiadiazole according to Method B in 50% yield. High resolution mass spectrometry (HRMS, ESI) calculated value C14H15N4O4SF3+H 393.0844 and measured value 393.0838.

References

[1] Patent: US2003/236287, 2003, A1. Location in patent: Page 38, 39
[2] Patent: US2003/236287, 2003, A1. Location in patent: Page 41
[3] Molecules, 2013, vol. 18, # 8, p. 9603 - 9622
[4] Patent: US2017/2028, 2017, A1. Location in patent: Paragraph 0162; 0163
[5] Chemistry - A European Journal, 2013, vol. 19, # 4, p. 1346 - 1356

2-METHOXYMETHYL METHANSULFONATE synthesis

616-47-7
109-86-4
124-63-0
16427-44-4
35487-17-3
Synthesis of 2-METHOXYMETHYL METHANSULFONATE from 1-Methylimidazole and 2-Methoxyethanol and Methanesulfonyl chloride

2-METHOXYMETHYL METHANSULFONATE Preparation Products And Raw materials

Raw materials

2-Methoxyethanol 1-Methylimidazole Methanesulfonyl chloride Dichloromethane Triethylamine

Preparation Products

2-METHOXYMETHYL METHANSULFONATE Suppliers

Global( 99)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13493 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49975 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29798 58
Alfa Chemistry 		info@alfa-chemistry.com United States 2344 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52846 58
Labnetwork lnc. 		+86-27-50766799 +8618062016861 contact@labnetwork.com China 19987 58
GLR Innovations 		+91 9891111994 info@glrgroup.in India 4535 58
PT CHEM GROUP LIMITED 		+86-85511178; peter68@ptchemgroup.com China 35425 58
GIHI CHEMICALS CO.,LIMITED 		+8618058761490 info@gihichemicals.com China 49944 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
Supplier Advantage
Shanghai Daken Advanced Materials Co.,Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Alfa Chemistry 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
Labnetwork lnc. 		58
GLR Innovations 		58
PT CHEM GROUP LIMITED 		58
GIHI CHEMICALS CO.,LIMITED 		58
Aladdin Scientific 		58

View Lastest Price from 2-METHOXYMETHYL METHANSULFONATE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-METHOXYMETHYL METHANSULFONATE pictures 2020-01-13 2-METHOXYMETHYL METHANSULFONATE
16427-44-4
 US $1.00 / KG 1g 99.0% 100kg Career Henan Chemical Co

2-METHOXYMETHYL METHANSULFONATE Spectrum

2-METHOXYMETHYL METHANSULFONATE(16427-44-4)MS2-METHOXYMETHYL METHANSULFONATE(16427-44-4)1HNMR2-METHOXYMETHYL METHANSULFONATE(16427-44-4)13CNMR2-METHOXYMETHYL METHANSULFONATE(16427-44-4)IR1

16427-44-4(2-METHOXYMETHYL METHANSULFONATE)Related Search:

5'-Tosyladenosine (-)-1,4-DI-O-TOSYL-2,3-O-ISOPROPYLIDENETHREITOL (R)-(+)-1-BENZOYLOXY-2-BENZYLOXY-3-TOSYLOXYPROPANE (R)-(-)-Glycidyl nosylate Tri(Ethylene Glycol) DI-P-Toluenesulfonate
PENTA(ETHYLENE GLYCOL) DI-P-TOLUENESULFONATE Methyl 2,3-O-isopropylidene-5-O-(p-tolylsulfonyl)-beta-D-ribofuranoside 2'-TOSYLADENOSINE DIETHYLENE GLYCOL BIS(P-TOLUENESULFONATE) 2-METHOXYETHYL P-TOLUENESULFONATE
(R)-(-)-2,2-DIMETHYL-1,3-DIOXOLAN-4-YLMETHYL P-TOLUENESULFONATE (2R)-(-)-Glycidyl tosylate TATM 1,6-ANHYDRO-3,4-O-ISOPROPYLIDENE-2-TOSYL-B-D-GALACTOPYRANOSE 5-O-CARBOMETHOXY-1,2-O-ISO-PROPYLIDENE-3-O-(P-TOLYL-SULFONYL)-ALPHA-D-XYLOFURANOSE
2,2-DIMETHYL-1,3-DIOXOLAN-4-YLMETHYL P-TOLUENESULFONATE 1,2-O-Isopropylidene-5-O-p-toluenesulfonyl-a-D-xylofuranose METHYL 6-O-TOSYL-ALPHA-D-GLUCOPYRANOSIDE

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2-METHOXYETHYL METHANESULFONATE METHANESULFONIC ACID 2-METHOXYETHYL ESTER 2-Methoxymethyl Methansulfonate 2-MethoxyethylMethanesulfonate> Ethanol, 2-methoxy-, 1-methanesulfonate 16427-44-4