Selumetinib
|
- $10 - $3538
- Product name: Selumetinib
- CAS: 606143-52-6
- MF: C17H15BrClFN4O3
- MW: 457.68
- EINECS:207-313-3
- MDL Number:MFCD11977472
- Synonyms:ARRY 142886;AZD 6244;Selumetinib AZD624;5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-car;Selumetinib;5-(4-Bromo-2-chlorophenylamino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzo[d]imidazole-6-carboxamide;6-(4-Bromo-2-chlorophenylamino)-7-fluoro-N-(2-hydroxyethoxy)-3-methyl-3H-benzo[d]imidazole-5-carboxamide;SeluMatinib(5-[(4-BroMo-2-chlorophenyl)aMino]-4-fluoro-N-(2-hydroxyethoxy)-1-Methyl-1H-benziMidazole-6-carboxaMide
103 prices
Selected condition：
Brand
- aablocks
- AccelPharmtech
- ACHEMBLOCK
- Adipogen Life Sciences
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Apolloscientific
- Arctom
- AvaChem
- Axon Medchem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Labseeker
- Matrix Scientific
- Sigma-Aldrich
- Tocris
- TRC
Package
- 20mg
- 0.1g
- 200mg
- 0.25g
- 0.5g
- 2g
- 50.00g
- 100.00g
- 50
- 100g
- 10mM*1mLinDMSO
- 250.00g
- 1mg
- 10mM(in 1mL DMSO)
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- 5G
- 500mg
- 10mM(in1mLDMSO)
- Manufactureraablocks
- Product numberAA0037DV
- Product description5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide 99%
- Packaging1mg
- Price$10
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0037DV
- Product description5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide ≥99%
- Packaging25mg
- Price$30
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0037DV
- Product description5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide 99%
- Packaging50mg
- Price$46
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0037DV
- Product description5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide 99%
- Packaging100mg
- Price$60
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0037DV
- Product description5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide 99%
- Packaging250mg
- Price$147
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0037DV
- Product description5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide
- Packaging500mg
- Price$179
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0037DV
- Product description5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide
- Packaging1g
- Price$258
- Updated2026-05-28
- Buy
- ManufacturerAccelPharmtech
- Product numberLW2675
- Product descriptionSelumetinib 99.00%
- Packaging1G
- Price$240
- Updated2026-05-21
- Buy
- ManufacturerAccelPharmtech
- Product numberLW2675
- Product descriptionSelumetinib 99.00%
- Packaging5G
- Price$930
- Updated2026-05-21
- Buy
- ManufacturerACHEMBLOCK
- Product number10381
- Product descriptionSelumetinib 98%
- Packaging5G
- Price$392
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product number10381
- Product descriptionSelumetinib 98%
- Packaging1G
- Price$131
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product number10381
- Product descriptionSelumetinib 98%
- Packaging100MG
- Price$27
- Updated2026-05-27
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1016-M001
- Product descriptionSelumetinib ≥95%
- Packaging1mg
- Price$96
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1016-M005
- Product descriptionSelumetinib ≥95%
- Packaging5mg
- Price$144
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1016-M010
- Product descriptionSelumetinib ≥95%
- Packaging10mg
- Price$216
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1016-M010
- Product descriptionSelumetinib ≥95%
- Packaging10mg
- Price$239
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA0037DV | 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide 99% | 1mg | $10 | 2026-05-28 | Buy |
| aablocks | AA0037DV | 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide ≥99% | 25mg | $30 | 2026-05-28 | Buy |
| aablocks | AA0037DV | 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide 99% | 50mg | $46 | 2026-05-28 | Buy |
| aablocks | AA0037DV | 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide 99% | 100mg | $60 | 2026-05-28 | Buy |
| aablocks | AA0037DV | 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide 99% | 250mg | $147 | 2026-05-28 | Buy |
| aablocks | AA0037DV | 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide | 500mg | $179 | 2026-05-28 | Buy |
| aablocks | AA0037DV | 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide | 1g | $258 | 2026-05-28 | Buy |
| AccelPharmtech | LW2675 | Selumetinib 99.00% | 1G | $240 | 2026-05-21 | Buy |
| AccelPharmtech | LW2675 | Selumetinib 99.00% | 5G | $930 | 2026-05-21 | Buy |
| ACHEMBLOCK | 10381 | Selumetinib 98% | 5G | $392 | 2026-05-27 | Buy |
| ACHEMBLOCK | 10381 | Selumetinib 98% | 1G | $131 | 2026-05-27 | Buy |
| ACHEMBLOCK | 10381 | Selumetinib 98% | 100MG | $27 | 2026-05-27 | Buy |
| Adipogen Life Sciences | SYN-1016-M001 | Selumetinib ≥95% | 1mg | $96 | 2026-05-06 | Buy |
| Adipogen Life Sciences | SYN-1016-M005 | Selumetinib ≥95% | 5mg | $144 | 2026-05-06 | Buy |
| Adipogen Life Sciences | SYN-1016-M010 | Selumetinib ≥95% | 10mg | $216 | 2021-12-16 | Buy |
| Adipogen Life Sciences | SYN-1016-M010 | Selumetinib ≥95% | 10mg | $239 | 2026-05-06 | Buy |
Properties
Melting point :>219°C (dec.)
Density :1.69
storage temp. :-20°
solubility :Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 2 mg/ml)
form :Beige powder.
pka :14.20±0.10(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
InChI :InChI=1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)
InChIKey :CYOHGALHFOKKQC-UHFFFAOYSA-N
SMILES :C1N(C)C2=CC(C(NOCCO)=O)=C(NC3=CC=C(Br)C=C3Cl)C(F)=C2N=1
Density :1.69
storage temp. :-20°
solubility :Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 2 mg/ml)
form :Beige powder.
pka :14.20±0.10(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
InChI :InChI=1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)
InChIKey :CYOHGALHFOKKQC-UHFFFAOYSA-N
SMILES :C1N(C)C2=CC(C(NOCCO)=O)=C(NC3=CC=C(Br)C=C3Cl)C(F)=C2N=1
Safety Information
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| Signal word: | Danger | ||||||||||||||||||||||||||||
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Description
MEK kinases are central components of diverse intracellular signaling pathways. MEK1 and MEK2 specifically act downstream of growth factor receptors and the proto-oncogenes Ras and Raf to activate ERK1 and ERK2, often leading to an increase in cell proliferation. AZD 6244 is a potent, highly selective inhibitor of MEK1 and MEK2 (IC50 = 14 and 530 nM, respectively). It weakly inhibits the EGF receptor (IC50 = 7.0 μM) and has no effect on a large panel of other kinases. AZD 6244 suppresses the growth of tumors displaying high levels of phosphorylated MEK1/2 or ERK1/2. In addition to suppressing growth, it induces apoptosis and differentiation within tumors. AZD 6244 has potential, alone or in combination therapy, for promoting tumor regression in various forms of cancer, including those involving mutations of the proto-oncogenes Ras and Raf.Related product price
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Suppliers and manufacturers
Zhengzhou Anbu Chem Co.,Ltd
Selumetinib
CAS:606143-52-6
Shaanxi Xianhe Biotech Co., Ltd
Selumetinib
CAS:606143-52-6
Cangzhou Kangrui Pharma Tech Co. Ltd.,
Selumetinib
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Beijing Yibai Biotechnology Co., Ltd
Capot Chemical Co.,Ltd.
Nanjing Finetech Chemical Co., Ltd.
ATK CHEMICAL COMPANY LIMITED
Jurong Coupling Biotechnology Co., Ltd.
Selumetinib AZD6244
CAS:606143-52-6