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Carbachol

Carbachol
Carbachol structure
CAS No.
51-83-2
Chemical Name:
Carbachol
Synonyms
Doryl;Moryl;tl457;Carba;Lentin;TL 457;Carbyl;carbach;Jestryl;Lentine
CBNumber:
CB1685095
Molecular Formula:
C6H15N2O2.Cl
Formula Weight:
182.65
MOL File:
51-83-2.mol

Carbachol Properties

Melting point:
210 °C (dec.) (lit.)
Density 
1.2798 (rough estimate)
refractive index 
1.5557 (estimate)
storage temp. 
Desiccate at RT
solubility 
H2O: 1 g/mL
form 
crystalline
pka
pKa 4.8 (Uncertain)
color 
white
Water Solubility 
1.0 G/ML
Sensitive 
Hygroscopic
Merck 
14,1779
BRN 
3917459
CAS DataBase Reference
51-83-2(CAS DataBase Reference)
FDA UNII
8Y164V895Y
NIST Chemistry Reference
Carbachol(51-83-2)
EPA Substance Registry System
Carbachol chloride (51-83-2)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H300
Precautionary statements  P270-P301+P310a-P321-P405-P501a-P264-P301+P310
Hazard Codes  T
Risk Statements  25-36/37/38
Safety Statements  45-36/37/39-28A-26
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
RTECS  GA0875000
TSCA  Yes
HazardClass  6.1
PackingGroup  II
HS Code  29239000
Toxicity LD50 in mice (mg/kg): 15 orally, 0.3 i.v. (Molitor)

Carbachol price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 212385-M Carbachol 51-83-2 100mg-m $78.1 2020-08-18 Buy
Sigma-Aldrich 212385-M Carbachol - CAS 51-83-2 - Calbiochem An unsubstituted carbamoyl ester that acts as an agonist for nicotinic and muscarinic acetylcholine receptors. 51-83-2 100 mg $78.1 2021-03-22 Buy
Sigma-Aldrich Y0000113 Carbachol European Pharmacopoeia (EP) Reference Standard 51-83-2 $190 2021-03-22 Buy
Sigma-Aldrich 1092009 Carbachol United States Pharmacopeia (USP) Reference Standard 51-83-2 200mg $366 2021-03-22 Buy
TCI Chemical C0596 Carbamylcholine Chloride >99.0%(T) 51-83-2 10g $112 2021-03-22 Buy

Carbachol Chemical Properties,Uses,Production

Chemical Properties

white crystalline powder

Chemical Properties

Carbachol chloride is a crystalline odorless powder which, on standing in an open container, develops a faint odor resembling that of an aliphatic amine.

Originator

Miostat,Alcon,US,1979

Uses

Carbamylcholine Chloride is a cholinergic receptor agonist. Studies show that Carbamylcholine Chloride is resistant to the action of cholinesterases. Carbamylcholine Chloride also displays antiapoptotic effects in cerebellar granule neurons.

Uses

cholinergic, miotic

Definition

An acetylcholine counterfit molecule that is not inactivated by acetylcholinesterase and is a slowly hydrolyzed cholinergic agonist that acts at both muscarinic and nicotinic receptors.

Manufacturing Process

About 14 g of choline chloride are stirred with a solution of about 20 g of phosgene in 100 g of chloroform for about two hours at room temperature. The mixture becomes a two-phase liquid mixture. Hydrochloric acid and excess phosgene are removed by distillation in vacuo. Chloroform is added to the syrup, and the mixture is then added to a solution of excess ammonia in chloroform which was cooled with solid carbon dioxide-acetone. The mixture is filtered, and the solid is extracted with hot absolute alcohol. The solid in the alcoholic solution is precipitated with ether, and filtered. It is recrystallized from a methyl alcohol-ether mixture; the carbaminoyl-choline chloride obtained has a melting point of about 208°-210°C.

brand name

Carbastat (Novartis); Miostat (Alcon).

Therapeutic Function

Cholinergic

General Description

Prismatic crystals or powder. Odorless, but develops a faint odor of aliphatic amine upon standing in an open container. Cholinergic, parasympathomimetic, used chiefly in large animals, especially for colic in the horse.

General Description

Carbachol forms a carbamylester in the active site of AChE, which is hydrolyzedmore slowly than an acetyl ester. This slower hydrolysis ratereduces the amount of free enzyme and prolongs the durationof ACh in the synapse. Carbachol also stimulates theautonomic ganglia and causes contraction of skeletal musclebut differs from a true muscarinic agent in that it does nothave cardiovascular activity despite the fact that it seems toaffect M2 receptors.

Air & Water Reactions

Hygroscopic.

Reactivity Profile

Carbachol is a carbamate ester. Carbamates are chemically similar to, but more reactive than amides. Like amides they form polymers such as polyurethane resins. Carbamates are incompatible with strong acids and bases, and especially incompatible with strong reducing agents such as hydrides. Flammable gaseous hydrogen is produced by the combination of active metals or nitrides with carbamates. Strongly oxidizing acids, peroxides, and hydroperoxides are incompatible with carbamates.

Hazard

Deadly poison; may cause lowered blood pressure, venous dilation, nausea or vomiting, sweating and lachrymation; a parasympathetic nerve stimulant.

Health Hazard

Highly toxic by mouth.

Fire Hazard

When heated to decomposition, Carbachol emits very toxic fumes of chloride and nitrogen oxides. The aqueous solution is stable even when heated.

Biological Activity

Cholinergic receptor agonist that is resistant to the action of cholinesterases. Blocks apoptosis in cerebellar granule neurons.

Clinical Use

Carbachol is a miotic and has been used to reduce the intraoculartension of glaucoma when a response cannot beobtained with pilocarpine or neostigmine. Penetration of thecornea is poor but can be enhanced by the use of a wettingagent in the ophthalmic solution. In addition to its topicaluse for glaucoma, carbachol is used during ocular surgery,when a more prolonged miosis is required than can be obtainedwith ACh chloride.

Potential Exposure

Used in veterinary medicine as a cholinergic; parasympathomimetic, used chiefly in large animals, especially for colic in the horse

Shipping

UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1- Poisonous materials, Technical Name Required.

Incompatibilities

Carbachol chloride is a carbamate ester. Esters are generally incompatible with nitrates. Moisture may cause hydrolysis or other forms of decomposition. Carbamates are incompatible with strong acids and bases, and especially incompatible with strong reducing agents such as hydrideds and active metals. Contact with active metals or nitrides form flammable gaseous hydrogen. Incompatible with strongly oxidizing acids, peroxides, and hydroperoxides.

Waste Disposal

It is inappropriate and possibly dangerous to the environment to dispose of expired or waste pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged, and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.

Carbachol Preparation Products And Raw materials

Raw materials

Preparation Products


Carbachol Suppliers

Global( 105)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5361 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58
career henan chemical co
13203830695 0086-371-86658258
0086-371-86658258 factory@coreychem.com CHINA 29865 58
Dideu Industries Group Limited
029-88380327
Service@dideu.com CHINA 29986 58
AFINE CHEMICALS LIMITED
008657185134551
008657185134895 info@afinechem.com CHINA 15559 58
Dayang Chem (Hangzhou) Co.,Ltd.
17705817739 +86-571-88938639
+86-571-88938652,+86-571- 88492614 info@dycnchem.com CHINA 52932 58
Shijiazhuang Tongyang Import and Export Co., LTD

admin@sjztongyang.com CHINA 995 58
Mainchem Co., Ltd. +86-0592-6210733
+86-0592-6210733 sale@mainchem.com CHINA 32439 55
Chemwill Asia Co.,Ltd. 86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23975 58
Shandong Baoshilun Furuida Pharmaceutical Co., Ltd. --
-- hongjie.hu@bausch.com China 4 58

View Lastest Price from Carbachol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-08-14 Carbachol
51-83-2
1g 99.9% 500000kgs Shijiazhuang tongyang Import and Export Co., LTD
2021-08-04 Carbachol
51-83-2
US $1.00 / PCS 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.
2021-07-28 Carbachol USP/EP/BP
51-83-2
US $1.10 / g 1g 99.9% 100 Tons min Dideu Industries Group Limited

Carbachol Spectrum


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