ChemicalBook >> CAS DataBase List >>Icotinib

Icotinib

CAS No.
610798-31-7
Chemical Name:
Icotinib
Synonyms
ConMana;N-(3-Ethynylphenyl)-7,8,10,11,13,14-hexahydro-[1,4,7,10]tetraoxacyclododecino[2,3-g]quinazolin-4-amine;otinib;CS-908;BP-1096;BPI-2009;Icotinib;Lcotinib;BPI-2009H;Icotinib BP-1096
CBNumber:
CB82616025
Molecular Formula:
C22H21N3O4
Molecular Weight:
391.42
MDL Number:
MFCD22124501
MOL File:
610798-31-7.mol
MSDS File:
SDS
Last updated:2023-06-08 09:03:09

Icotinib Properties

Boiling point 581℃
Density 1.31
Flash point 305℃
storage temp. Store at -20°C
solubility insoluble in H2O; ≥129.6 mg/mL in DMSO; ≥14.13 mg/mL in EtOH with ultrasonic
form Powder
pka 5.32±0.20(Predicted)
FDA UNII 9G6U5L461Q
ATC code L01EB08

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
HS Code  29339900
NFPA 704
0
2 0

Icotinib price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Activate Scientific AS117640 Icotinib 98+% 610798-31-7 1mg $52 2021-12-16 Buy
ChemScene CS-2017 Icotinib 99.79% 610798-31-7 5mg $70 2021-12-16 Buy
ChemScene CS-2017 Icotinib 99.79% 610798-31-7 10mg $100 2021-12-16 Buy
Activate Scientific AS117640 Icotinib 98+% 610798-31-7 5mg $136 2021-12-16 Buy
AK Scientific 2468AH Icotinib 610798-31-7 5mg $153 2021-12-16 Buy
Product number Packaging Price Buy
AS117640 1mg $52 Buy
CS-2017 5mg $70 Buy
CS-2017 10mg $100 Buy
AS117640 5mg $136 Buy
2468AH 5mg $153 Buy

Icotinib Chemical Properties,Uses,Production

Uses

Icotinib is a highly selective, 1st generation EGFR-TKI (epidermal growth factor receptor tyrosine kinase) inhibitor. The mutations of EGFR is associated with many kinds of cancers. Currently, Icotinib is under investigation for its treatment efficacy on some cancer such as non-small cell lung cancer. Icotinib take effects through binding reversibly to the ATP binding site of the EGFR protein, further preventing completion of the signal transduction cascade. 

Description

Icotinib is also known as ConMana. It is a highly selective, first-generation inhibitor of epidermal growth factor receptor tyrosine kinase (EGFR-TKI), whose mutation and overexpression is involved in many kinds of cancer. Icotinib is a quinazoline derivative that binds reversibly to the ATP binding site of the EGFR protein, being capable of blocking the signal transduction cascade. It is currently under investigation for its treatment efficacy on the EGFR+ Non-small cell lung cancer.

Uses

Icotinib is a potent and specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) with IC50 of 5 nM.

Indications

Icotinib (Conmana?, BetaPharma), an EGFR inhibitor, was approved by the China State FDA in 2011 for the treatment of NSCLC. Icotinib resembles erlotinib in possessing the N-(3-ethylnylphenyl) quinazolin-4-amine core scaffold of erlotinib that binds to the EGFR ATP pocket. An adjacent hydrophobic group was also retained while the solvent exposed two 2-methoxyethyoxysubstituents at the 6- and 7-positions of the quinazoline core were cyclized to afford the tetraoxacyclododecene moiety of icotinib. Efficacy and safety of icotinib as first-line therapy in patients has been evaluated for advanced NSCLC in recent clinical studies.

References

Tan, F., et al. "Icotinib (BPI-2009H), a novel EGFR tyrosine kinase inhibitor, displays potent efficacy in preclinical studies. " Lung Cancer76.2(2012):177-82.
Shi, Y., et al. "Icotinib versus gefitinib in previously treated advanced non-small-cell lung cancer (ICOGEN): a randomised, double-blind phase 3 non-inferiority trial." Lancet Oncology 14.10(2013):953-61.
Sun, Y., Y. Shi, and L. Zhang. "A randomized, double-blind phase III study of icotinib versus gefitinib in patients with advanced non-small cell lung cancer (NSCLC) previously treated with chemotherapy (ICOGEN)."Journal of Thoracic Oncology 29.15(2011):-.
https://en.wikipedia.org/wiki/Icotinib

Icotinib Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 106)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29797 60
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29919 58
Hubei xin bonus chemical co. LTD
86-13657291602 linda@hubeijusheng.com CHINA 22968 58
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250 1026@dideu.com China 29831 58
Baoji Guokang Bio-Technology Co., Ltd.
0917-3909592 13892490616 gksales1@gk-bio.com China 9340 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Coresyn Pharmatech Co., Ltd.
+86-571-86626709 +86-18157142896 cbc@coresyn.com China 9991 58

View Lastest Price from Icotinib manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Icotinib pictures 2021-07-13 Icotinib
610798-31-7
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
Icotinib pictures 2021-07-10 Icotinib
610798-31-7
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
Icotinib pictures 2019-07-06 Icotinib
610798-31-7
US $1.00 / KG 1KG 95% 500kg Career Henan Chemical Co
  • Icotinib pictures
  • Icotinib
    610798-31-7
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd
  • Icotinib pictures
  • Icotinib
    610798-31-7
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd
  • Icotinib pictures
  • Icotinib
    610798-31-7
  • US $1.00 / KG
  • 95%
  • Career Henan Chemical Co

Icotinib Spectrum

BPI-2009 BP-1096 BPI-2009H Lcotinib Icotinib [1,4,7,10]Tetraoxacyclododecino[2,3-g]quinazolin-4-amine, N-(3-ethynylphenyl)-7,8,10,11,13,14-hexahydro- Icotinib int. N-1 N-(3-Ethynylphenyl)-7,8,10,11,13,14-hexahydro-[1,4,7,10]tetraoxacyclododecino[2,3-g]quinazolin otinib Icotinib USP/EP/BP Icotinib(BPI-2009H) CS-908 Icotinib BP-1096 Icotinib, 98%, a potent EGFR inhibitor BPI-2009H;BPI-2009 Icotinib (BPI-2009) ConMana N-(3-Ethynylphenyl)-7,8,10,11,13,14-hexahydro-[1,4,7,10]tetraoxacyclododecino[2,3-g]quinazolin-4-amine Icotinib,apotentEGFRinhibitor 610798-31-7 610793-31-7 Inhibitors API