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S-Ruxolitinib (INCB018424)

S-Ruxolitinib (INCB018424) structure

CAS No.: 941685-37-6

Chemical Name:: S-Ruxolitinib (INCB018424)

Synonyms: CS-1401;INCB 18424;S-INCB18424;S-Ruxolitinib;Ruxolitinib Impurity A;S-Ruxolitinib (INCB018424);Ruxolitinib (S enantioMer);RUXOLITINIB S ENANTIOMER;INCB18424;S-Ruxolitinib INCB018424 INCB-018424;Ruxolitinib Impurity 1（(S)-Ruxolitinib）

CBNumber:: CB82665159

Molecular Formula:: C17H18N6

Molecular Weight:: 306.36

MDL Number:: MFCD13184797

MOL File:: 941685-37-6.mol

MSDS File:: SDS

Last updated:2023-05-18 11:31:16

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S-Ruxolitinib (INCB018424) Properties

Melting point	138-143oC
Density	1.40±0.1 g/cm3(Predicted)
storage temp.	-20°C Freezer
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	11.63±0.50(Predicted)
color	White

S-Ruxolitinib (INCB018424) price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	C988940	(3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile(ent-Ruxolitinib)	941685-37-6	100mg	$1465	2021-12-16	Buy
Biorbyt Ltd	orb154739	S-Ruxolitinib (INCB018424) >98%	941685-37-6	1g	$1802	2021-12-16	Buy
ChemScene	CS-2768	Ruxolitinib(Senantiomer) 99.92%	941685-37-6	5mg	$72	2021-12-16	Buy
ChemScene	CS-2768	Ruxolitinib(Senantiomer) 99.92%	941685-37-6	10mg	$84	2021-12-16	Buy
ChemScene	CS-2768	Ruxolitinib(Senantiomer) 99.92%	941685-37-6	50mg	$144	2021-12-16	Buy

Product number	Packaging	Price	Buy
C988940	100mg	$1465	Buy
orb154739	1g	$1802	Buy
CS-2768	5mg	$72	Buy
CS-2768	10mg	$84	Buy
CS-2768	50mg	$144	Buy

S-Ruxolitinib (INCB018424) Chemical Properties,Uses,Production

Uses

(3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile is a newly developed JAK2 inhibitor therapy aimed to improve MPN-associated splenomegaly and systemic symptoms. The opposite enantiomer of Ruxolitinib (R702000).

Biological Activity

s-ruxolitinib is the chirality of incb018424, is a potent and selective small-molecule janus kinase 1 (jak1) and jak2 inhibitor. it was initially developed to target the constitutive activation of the jak-stat pathway. janus kinases (jaks) are a family of cytoplasmic tyrosine kinases that mediates signals from the receptors for various cytokines and growth factors that have a key role in haematopoiesis and immune function. ruxolitinib maintains its anti-jak activity by competitive inhibition of the atp-binding catalytic site of the kinase domain. ruxolitinib is well absorbed at >95%. exposure of jak2v617f-positive ba/f3 cells to ruxolitinib iss shown to result in reduced cellular proliferation.ruben a. mesa, uma yasothan, peter kirkpatrick. ruxolitinib. nature reviews drug discovery. 2012; 11: 103-104john mascarenhas, ronald hoffman. ruxolitinib: the first fda approved therapy for the treatment of myeloﬁbrosis. clinical cancer research. 2012; 18(11): 3008 - 3014

target

JAK1

S-Ruxolitinib (INCB018424) Preparation Products And Raw materials

Raw materials

Preparation Products

S-Ruxolitinib (INCB018424) Suppliers

Global( 107)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14336	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	CHINA	52867	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
PT CHEM GROUP LIMITED	+86-85511178 +86-85511178	peter68@ptchemgroup.com	China	35453	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58

Supplier	Advantage
Standardpharm Co. Ltd.	58
career henan chemical co	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Nantong HI-FUTURE Biology Co., Ltd.	58
TargetMol Chemicals Inc.	58
PT CHEM GROUP LIMITED	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
LEAPCHEM CO., LTD.	58

View Lastest Price from S-Ruxolitinib (INCB018424) manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-12-20	S-Ruxolitinib(INCB018424) 941685-37-6	US $1.00 / g	1g	99%	g/kg/T	Career Henan Chemical Co

S-Ruxolitinib(INCB018424)
941685-37-6
US $1.00 / g
99%
Career Henan Chemical Co

S-Ruxolitinib (INCB018424) Spectrum

S-Ruxolitinib (INCB018424)(941685-37-6)¹HNMR

941685-37-6(S-Ruxolitinib (INCB018424))Related Search:

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S-Ruxolitinib (INCB018424) S-Ruxolitinib INCB 18424 1H-Pyrazole-1-propanenitrile, β-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-, (βS)- Ruxolitinib (S enantioMer) (3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-1H-pyrazol-1-yl]propanenitrile RUXOLITINIB S ENANTIOMER;INCB18424 (3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (ent-Ruxolitinib) CS-1401 Ruxolitinib Impurity 1（(S)-Ruxolitinib） (S)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile Ruxolitinib Impurity A "(3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile"Q: What is "(3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile" Q: What is the CAS Number of "(3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile" Q: What is the storage condition of "(3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile" S-Ruxolitinib INCB018424 INCB-018424 S-INCB18424 941685-37-6 Inhibitor Inhibitors Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals JAK STAT