S-Ruxolitinib (INCB018424)
- CAS No.
- 941685-37-6
- Chemical Name:
- S-Ruxolitinib (INCB018424)
- Synonyms
- CS-1401;INCB 18424;S-INCB18424;S-Ruxolitinib;Ruxolitinib Impurity A;S-Ruxolitinib (INCB018424);Ruxolitinib (S enantioMer);RUXOLITINIB S ENANTIOMER;INCB18424;S-Ruxolitinib INCB018424 INCB-018424;Ruxolitinib Impurity 1((S)-Ruxolitinib)
- CBNumber:
- CB82665159
- Molecular Formula:
- C17H18N6
- Molecular Weight:
- 306.36
- MDL Number:
- MFCD13184797
- MOL File:
- 941685-37-6.mol
- MSDS File:
- SDS
S-Ruxolitinib (INCB018424) price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | C988940 | (3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile(ent-Ruxolitinib) | 941685-37-6 | 100mg | $1465 | 2021-12-16 | Buy |
Biorbyt Ltd | orb154739 | S-Ruxolitinib (INCB018424) >98% | 941685-37-6 | 1g | $1802 | 2021-12-16 | Buy |
ChemScene | CS-2768 | Ruxolitinib(Senantiomer) 99.92% | 941685-37-6 | 5mg | $72 | 2021-12-16 | Buy |
ChemScene | CS-2768 | Ruxolitinib(Senantiomer) 99.92% | 941685-37-6 | 10mg | $84 | 2021-12-16 | Buy |
ChemScene | CS-2768 | Ruxolitinib(Senantiomer) 99.92% | 941685-37-6 | 50mg | $144 | 2021-12-16 | Buy |
S-Ruxolitinib (INCB018424) Chemical Properties,Uses,Production
Uses
(3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile is a newly developed JAK2 inhibitor therapy aimed to improve MPN-associated splenomegaly and systemic symptoms. The opposite enantiomer of Ruxolitinib (R702000).
Biological Activity
s-ruxolitinib is the chirality of incb018424, is a potent and selective small-molecule janus kinase 1 (jak1) and jak2 inhibitor. it was initially developed to target the constitutive activation of the jak-stat pathway. janus kinases (jaks) are a family of cytoplasmic tyrosine kinases that mediates signals from the receptors for various cytokines and growth factors that have a key role in haematopoiesis and immune function. ruxolitinib maintains its anti-jak activity by competitive inhibition of the atp-binding catalytic site of the kinase domain. ruxolitinib is well absorbed at >95%. exposure of jak2v617f-positive ba/f3 cells to ruxolitinib iss shown to result in reduced cellular proliferation.ruben a. mesa, uma yasothan, peter kirkpatrick. ruxolitinib. nature reviews drug discovery. 2012; 11: 103-104john mascarenhas, ronald hoffman. ruxolitinib: the first fda approved therapy for the treatment of myelofibrosis. clinical cancer research. 2012; 18(11): 3008 - 3014
target
JAK1
S-Ruxolitinib (INCB018424) Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52861 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
PT CHEM GROUP LIMITED | +86-85511178 +86-85511178 | peter68@ptchemgroup.com | China | 35451 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
View Lastest Price from S-Ruxolitinib (INCB018424) manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2019-12-20 | S-Ruxolitinib(INCB018424)
941685-37-6
|
US $1.00 / g | 1g | 99% | g/kg/T | Career Henan Chemical Co |
- S-Ruxolitinib(INCB018424)
941685-37-6
- US $1.00 / g
- 99%
- Career Henan Chemical Co