ChemicalBook >> CAS DataBase List >>FLI-06
FLI-06
- CAS No.
- 313967-18-9
- Chemical Name:
- FLI-06
- Synonyms
- I-06;FLI-06;CS-1434;FLI-06 |FLI06;inhibit,Inhibitor,Notch,FLI-06,FLI06;FLI-06, 98%, a notch signaling and the early secretory pathway inhibitor;Cyclohexyl 1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylate;1,4,5,6,7,8-Hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylic acid cyclohexyl ester;3-QUINOLINECARBOXYLIC ACID, 1,4,5,6,7,8-HEXAHYDRO-2,7,7-TRIMETHYL-4-(4-NITROPHENYL)-5-OXO-, CYCLOHEXYL ESTER;1,4,5,6,7,8-Hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylic acid cyclohexyl ester FLI-06
- CBNumber:
- CB82682028
- Molecular Formula:
- C25H30N2O5
- Molecular Weight:
- 438.52
- MDL Number:
- MFCD00330996
- MOL File:
- 313967-18-9.mol
Last updated:2023-05-18 11:31:20
| Melting point | 199-202oC |
|---|---|
| Boiling point | 597.5±50.0 °C(Predicted) |
| Density | 1.25±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble5mg/mL, clear (warmed) |
| form | powder |
| pka | 0.78±0.70(Predicted) |
| color | white to beige |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week. |
FLI-06 price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0975 | FLI-06 ≥98% (HPLC) | 313967-18-9 | 5mg | $118 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0975 | FLI-06 ≥98% (HPLC) | 313967-18-9 | 25mg | $190.4 | 2024-03-01 | Buy |
| Cayman Chemical | 21272 | FLI-06 ≥98% | 313967-18-9 | 5mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 21272 | FLI-06 ≥98% | 313967-18-9 | 10mg | $146 | 2024-03-01 | Buy |
| Cayman Chemical | 21272 | FLI-06 ≥98% | 313967-18-9 | 25mg | $317 | 2024-03-01 | Buy |
FLI-06 Chemical Properties,Uses,Production
Description
FLI-06 (313967-18-9) was discovered in a screen designed to monitor the trafficking and processing of a ligand-independent Notch-enhanced GFP reporter. It was found to disrupt the Golgi apparatus in a manner distinct from that of brefeldin A. It inhibited general secretion at a step before exit from the ER which was accompanied by a tubule-to-sheet morphological transition of the ER. Thus FLI-06 is the first small molecule acting at such an early stage in secretory traffic.1
Uses
FLI-06 is a novel inhibitor of Notch signalling and the early secretory pathway.
References
1) Kramer?et al., (2013),?Small molecules intercept Notch signaling and the early secretory pathway; Nat. Chem. Biol.?9 731
FLI-06 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 92)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | 18522618860@163.com | China | 694 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
View Lastest Price from FLI-06 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-24 | 3-?Quinolinecarboxylic acid, 1,?4,?5,?6,?7,?8-?hexahydro-?2,?7,?7-?trimethyl-?4-?(4-?nitrophenyl)?-?5-?oxo-?, cyclohexyl ester
313967-18-9
|
US $1.00 / KG | 1KG | Min98% HPLC | g/kg/ton | Career Henan Chemical Co |
-
- 3-?Quinolinecarboxylic acid, 1,?4,?5,?6,?7,?8-?hexahydro-?2,?7,?7-?trimethyl-?4-?(4-?nitrophenyl)?-?5-?oxo-?, cyclohexyl ester
313967-18-9
- US $1.00 / KG
- Min98% HPLC
- Career Henan Chemical Co
313967-18-9(FLI-06)Related Search:
FLI-06
1,4,5,6,7,8-Hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylic acid cyclohexyl ester
1,4,5,6,7,8-Hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylic acid cyclohexyl ester FLI-06
3-QUINOLINECARBOXYLIC ACID, 1,4,5,6,7,8-HEXAHYDRO-2,7,7-TRIMETHYL-4-(4-NITROPHENYL)-5-OXO-, CYCLOHEXYL ESTER
FLI-06, 98%, a notch signaling and the early secretory pathway inhibitor
FLI-06 |FLI06
Cyclohexyl 1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylate
CS-1434
I-06
inhibit,Inhibitor,Notch,FLI-06,FLI06
313967-18-9
Inhibitors