12(R)-HETE
- CAS No.
- 82337-46-0
- Chemical Name:
- 12(R)-HETE
- Synonyms
- 12(R)-HETE;12(R)HETE,12(R) HETE;ZNHVWPKMFKADKW-ZYBDYUKJSA-N;12(R)-HETE Lipid Maps MS Standard;(R)-12-Hydroxyeicosatetraenoic acid;12(R)-hydroxy-5(Z),8(Z),10(E),14(Z)-ETA;12R-HYDROXY-5Z,8Z,10E,14Z-EICOSATETRAENOIC ACID;12(R)-HYDROXYEICOSA-5Z,8Z,10E,14Z-TETRAENOIC ACID;12(R)-hydroxy-(5Z,8Z,10E,14Z)-*eicosatetraenoic A;(5Z,8Z,10E,12R,14Z)-12-Hydroxy-5,8,10,14-icosatetraenoic acid
- CBNumber:
- CB8288367
- Molecular Formula:
- C20H32O3
- Molecular Weight:
- 320.47
- MDL Number:
- MFCD00065827
- MOL File:
- 82337-46-0.mol
- MSDS File:
- SDS
| storage temp. | -20°C |
|---|---|
| solubility | 0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS pH 7.2: 0.8 mg/ml |
| form | Liquid |
| color | Colorless to light yellow |
| FDA UNII | FD492J7LCU |
SAFETY
Risk and Safety Statements
| Hazard Codes | F,Xi |
|---|---|
| Risk Statements | 11-36/37/38 |
| Safety Statements | 16-26-36 |
12(R)-HETE price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 34560 | 12(R)-HETE ≥98% | 82337-46-0 | 25μg | $156 | 2026-04-30 | Buy |
| Cayman Chemical | 34560 | 12(R)-HETE ≥98% | 82337-46-0 | 50μg | $294 | 2026-04-30 | Buy |
| Cayman Chemical | 34560 | 12(R)-HETE ≥98% | 82337-46-0 | 100μg | $432 | 2026-04-30 | Buy |
| Biosynth | HDA33746 | 12(R)-Hydroxy-5(Z),8(Z),10(E),14(Z)-eicosatetraenoic acid | 82337-46-0 | 1mg | $9481.89 | 2026-06-04 | Buy |
| Arctom | HY-124404 | 12(R)-HETE 99.0% | 82337-46-0 | 5μg(312.04μM*50μLinEthanol)(Solvent) | $119 | 2026-05-26 | Buy |
12(R)-HETE Chemical Properties, Uses, Production
Uses
12(R)-HETE is a metabolite of Arachidonic acid, AA (HY-109590) and can be found in skin from psoriatic lesions. 12(R)-HETE induces lymphocytes chemotaxis, stimulates calcium mobilization and chemotaxis in neutrophils via the BLT1 receptor, activates the aryl hydrocarbon receptor, and inhibits Na+/K+ ATPase activity in the corneal epithelium[1][2][3][4].
Definition
ChEBI: A HETE having a (12R)-hydroxy group and (5Z)-, (8Z)-, (10E)- and (14Z)-double bonds.
References
[1] Schwartzman ML, et al., 12(R)-hydroxyicosatetraenoic acid: a cytochrome-P450-dependent arachidonate metabolite that inhibits Na+,K+-ATPase in the cornea. Proc Natl Acad Sci U S A. 1987 Nov;84(22):8125-9. DOI:10.1073/pnas.84.22.8125
[2] Bacon KB, et al., Contrasting in vitro lymphocyte chemotactic activity of the hydroxyl enantiomers of 12-hydroxy-5,8,10,14-eicosatetraenoic acid. Br J Pharmacol. 1988 Nov;95(3):966-74. DOI:10.1111/j.1476-5381.1988.tb11727.x
[3] Powell WS, et al., Effects of oxo and dihydro metabolites of 12-hydroxy-5,8,10,14-eicosatetraenoic acid on chemotaxis and cytosolic calcium levels in human neutrophils. J Leukoc Biol. 1995 Feb;57(2):257-63. DOI:10.1002/jlb.57.2.257
[4] Chiaro CR, et al., 12(R)-Hydroxy-5(Z),8(Z),10(E),14(Z)-eicosatetraenoic acid [12(R)-HETE], an arachidonic acid derivative, is an activator of the aryl hydrocarbon receptor. Mol Pharmacol. 2008 Dec;74(6):1649-56. DOI:10.1124/mol.108.049379
12(R)-HETE Preparation Products And Raw materials
Raw materials
Preparation Products
12(R)-HETE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Yichang Zhongyitai Trading Co., Ltd. | 0717-6449896 13886658719 | root@zhongyitai.com | China | 1978 | 58 |
| Alfa Chemistry | 1-516-6625404 | support@alfa-chemistry.com | United States | 9170 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8137 | 58 |
| amyjet | 4006800868;027-59626688 18771149750 | sales@amyjet.com | China | 2909 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Yiyan Biotechnology Co. , Ltd. | 021-69985186 13611928337 | 3427709316@qq.com | China | 7982 | 58 |
View Latest Price from 12(R)-HETE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-22 | 12(R)-HETE
82337-46-0
|
$1420.00 | 10g | TargetMol Chemicals Inc. |
-
- 12(R)-HETE
82337-46-0
- $1420.00
- TargetMol Chemicals Inc.
