Gemcitabine monophosphate
- CAS No.
- 1638288-31-9
- Chemical Name:
- Gemcitabine monophosphate
- Synonyms
- GemMP;Gemcitabine monophosphate disodium;Gemcitabine monophosphate disodium salt;Gemcitabine monophosphate disodium monohydrate;GEMCITABINE MONOPHOSPHATE DISODIUM SALT MONOHYDRATE; GEMCITABINE MONOPHOSPHATE DISODIUM; GEMMP;4-amino-1-((2r,4r,5r)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1h)-one, phosphate salt
- CBNumber:
- CB83172757
- Molecular Formula:
- C9H13F2N3NaO7P
- Molecular Weight:
- 367.18
- MDL Number:
- MFCD18252926
- MOL File:
- 1638288-31-9.mol
- MSDS File:
- SDS
| storage temp. | Store at 0-8 °C |
|---|---|
| solubility | DMSO:10.0(Max Conc. mg/mL);24.68(Max Conc. mM) |
| FDA UNII | OO7O3T57O3 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501 |
Gemcitabine monophosphate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FG183426 | Gemcitabine monophosphate disodium monohydrate | 1638288-31-9 | 2mg | $186.92 | 2026-06-04 | Buy |
| Biosynth | FG183426 | Gemcitabine monophosphate disodium monohydrate | 1638288-31-9 | 5mg | $389.4 | 2026-06-04 | Buy |
| Biosynth | FG183426 | Gemcitabine monophosphate disodium monohydrate | 1638288-31-9 | 10mg | $584.1 | 2026-06-04 | Buy |
| Biosynth | FG183426 | Gemcitabine monophosphate disodium monohydrate | 1638288-31-9 | 25mg | $973.5 | 2026-06-04 | Buy |
| Biosynth | FG183426 | Gemcitabine monophosphate disodium monohydrate | 1638288-31-9 | 50mg | $1557.5 | 2026-06-04 | Buy |
Gemcitabine monophosphate Chemical Properties, Uses, Production
Uses
Gemcitabine monophosphate (Gemcitabine 5′-phosphate) is one of the active intermediates of Gemcitabine (HY-17026). Gemcitabine monophosphate has a synergistic anti-cancer effect and can be delivered by formulating it into nanoparticles[1][2].
in vivo
Gemcitabine monophosphate (19.5 mg/kg, intravenous injection, every other day, four injections) combined with LCP loaded with VEGF siRNA and GMP shows anti-small cell lung cancer activity and induces apoptosis[1].
| Animal Model: | Subcutaneous and orthotopic xenograft mouse models of non-small cell lung cancer[1] |
| Dosage: | 19.5 mg/kg, every other day, four injections |
| Administration: | Intravenous injection (i.v.) |
| Result: | Induced tumor cell apoptosis to 30-40%, reduced tumor cell proliferation by 8 times, significantly reduced tumor microvessel density (MVD), and inhibited tumor mitosis. |
References
[1] Zhang Y, et al. Codelivery of VEGF siRNA and gemcitabine monophosphate in a single nanoparticle formulation for effective treatment of NSCLC. Mol Ther. 2013 Aug;21(8):1559-69. DOI:10.1038/mt.2013.120
[2] Miao L, et al. Nanoparticles with Precise Ratiometric Co-Loading and Co-Delivery of Gemcitabine Monophosphate and Cisplatin for Treatment of Bladder Cancer. Adv Funct Mater. 2014 Nov 12;24(42):6601-6611. DOI:10.1002/adfm.201401076
Gemcitabine monophosphate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7717 | 56 |
| Shanghai JiYi Biotechnology Co. Ltd. | 13621943973 | sales@shjiyipharmatech.com | China | 1166 | 55 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
| Medi-tech Bioscientific Co., Ltd. | 0519-83246372 13585352506 | China | 1838 | 58 | |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6288 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19935 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6745 | 58 |
| Shanghai Tachizaki Biomedical Research Center | 18014399201 | sales@chemlab-tachizaki.com | China | 2934 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 9067 | 58 |
