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METYRAPONE

METYRAPONE
METYRAPONE structure
CAS No.
54-36-4
Chemical Name:
METYRAPONE
Synonyms
su4885;su-4885;Su 4885;Metapyron;Metopiron;Metyrapon;METYRAPONE;Mepyrapone;Metapirone;Metapyrone
CBNumber:
CB8329426
Molecular Formula:
C14H14N2O
Formula Weight:
226.27
MOL File:
54-36-4.mol

METYRAPONE Properties

Melting point:
52-55 °C(lit.)
Boiling point:
367.89°C (rough estimate)
Density 
1.0852 (rough estimate)
refractive index 
1.6419 (estimate)
Flash point:
>230 °F
storage temp. 
Store at +4°C
solubility 
H2O: soluble (sparingly)
form 
solid
Merck 
13,6181
BRN 
163023
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  26
WGK Germany  3
RTECS  UC3050000
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

METYRAPONE price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 856525 2-Methyl-1,2-di-3-pyridyl-1-propanone 96% 54-36-4 1g $73.1 2018-11-13 Buy
Sigma-Aldrich 1443001 Metyrapone United States Pharmacopeia (USP) Reference Standard 54-36-4 200mg $338.1 2018-11-20 Buy
Cayman Chemical 14994 Metyrapone ≥98% 54-36-4 250mg $17 2018-11-13 Buy
Cayman Chemical 14994 Metyrapone ≥98% 54-36-4 1g $44 2018-11-13 Buy
Sigma-Aldrich M2696 Metyrapone ≥98% (HPLC), solid 54-36-4 10mg $55.1 2018-11-20 Buy

METYRAPONE Chemical Properties,Uses,Production

Uses

Diagnostic aid (pituitary function);steroid 11?-hydroxylase inhibitor

Uses

glucocorticoid synthesis inhibitor

brand name

Metopirone Ditartrate (Ciba-Geigy).

Biological Activity

Cytochrome P450 inhibitor. Blocks glucocorticoid synthesis via inhibition of steroid 11- β hydroxylase (CYP11B1) activity (IC 50 = 7.83 μ M). Also inhibits CYP3A4 and cytochrome P450-mediated ω / ω -1 hydroxylase activity.

Mechanism of action

Metyrapone (Metopirone) produces its primary pharmacological effect by inhibiting 11-β-hydroxylase, thereby causing diminished production and release of cortisol. The resulting reduction in the negative feedback of cortisol on the hypothalamus and pituitary causes an increase in corticotrophin release and in the secretion of precursor 11-deoxysteroids.

Clinical Use

Metyrapone is used in the differential diagnosis of both adrenocortical insufficiency and Cushing’s syndrome (hypercortisolism). The drug tests the functional competence of the hypothalamic–pituitary axis when the adrenals are able to respond to corticotrophin; that is, when primary adrenal insufficiency has been ruled out.
After metyrapone administration, a patient with a disease of pituitary origin cannot achieve a compensatory increase in the urinary excretion of 17-hydroxycorticosteroids or 11-deoxysteroids. Moreover, if pituitary corticotrophin is suppressed by an autonomously secreting adrenal carcinoma, there will be no increase in response to metyrapone. On the other hand, if pituitary corticotrophin secretion is maintained, as occurs in adrenal hyperplasia, the inhibition of corticoid synthesis produced by metyrapone will stimulate corticotrophin secretion and the release of metabolites of precursor urinary steroids, which can be measured as 17-hydroxycorticosteroids. Metyrapone is now used less frequently in the differential diagnosis of Cushing’s syndrome because of the ability to measure plasma corticotrophin directly.
The steroid-inhibiting properties of metyrapone have also been used in the treatment of Cushing’s syndrome, and it remains one of the more effective drugs used to treat this syndrome. However, the compensatory rise in corticotrophin levels in response to falling cortisol levels tends to maintain adrenal activity.This requires that glucocorticoids be administered concomitantly to suppress hypothalamic–pituitary activity. Although metyrapone interferes with 11β- and 18- hydroxylation reactions and thereby inhibits aldosterone synthesis, it may not cause mineralocorticoid deficiency because of the compensatory increased production of 11-desoxycorticosterone.

Side effects

Side effects associated with the use of metyrapone include gastrointestinal distress, dizziness, headache, sedation, and allergic rash. The drug should not be used in cases of adrenocortical insufficiency or when hypersensitivity reactions can be expected. When administered to pregnant women during the second or third trimesters, the drug may impair steroid biosynthesis in the fetus. Because metyrapone is relatively nontoxic, it is used in combination therapy with the more toxic aminoglutethimide to reduce its dosage.

METYRAPONE Preparation Products And Raw materials

Raw materials

Preparation Products


METYRAPONE Suppliers

Global( 59)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19919 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20516 58
Suzhou Ran enzyme Biotechnology Co., Ltd. 0512-62793604 18015430729
0512-62793604 tian8046@163.com China 115 58
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 3bsc@sina.com China 15884 69
Energy Chemical 021-58432009 / 400-005-6266
021-58436166-800 info@energy-chemical.com China 44046 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18
0086-571-85864795 sales@capotchem.com China 18230 66
BePharm Ltd 4001-647-117; 021-61629020
021-61629029 product@bidepharmatech.com China 24689 61
Chemfun Medical Technology(Shanghai) Co., Ltd. 021-67220633 & 021-37212706
+86-21-67220638 chemfun@chemfun.net China 21815 59
Syntechem Co.,Ltd Please Email
E-Mail Inquiry info@syntechem.com China 13013 57
Sinopharm Chemical Reagent Co,Ltd. 86-21-63210123
86-21-63290778 86-21-63218885 sj_scrc@sinopharm.com China 9851 79

View Lastest Price from METYRAPONE manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-16 METYRAPONE
54-36-4
US $7.00 / kg 1kg 99% 100kg career henan chemical co

METYRAPONE Spectrum


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