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Beraprost sodium

Beraprost sodium Structure
Beraprost sodium structure
CAS No.
88475-69-8
Chemical Name:
Beraprost sodium
Synonyms
BERAPROST SODIUM SALT;Dorner;ML 1129;TRK 100;Berasus;Careload;PROCYLIN;Procyclin;MDL 201129;Befraprost
CBNumber:
CB8761736
Molecular Formula:
C24H29NaO5
Molecular Weight:
420.47
MDL Number:
MFCD00911570
MOL File:
88475-69-8.mol
MSDS File:
SDS
Last updated:2024-05-14 10:14:29
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Beraprost sodium Properties

Melting point 204-206°C
storage temp. -20°C
solubility DMF:77.0(Max Conc. mg/mL);183.12(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);47.56(Max Conc. mM)
PBS (pH 7.2):19.0(Max Conc. mg/mL);45.19(Max Conc. mM)
form powder
color white to beige
InChIKey YTCZZXIRLARSET-LIIFYGAANA-M
SMILES [C@H]12[C@H](C[C@@H](O)[C@@H]1/C=C/[C@@H](O)C(C)CC#CC)OC1C(=CC=CC2=1)CCCC([O-])=O.[Na+] |&1:0,1,3,5,8,r|
CAS DataBase Reference 88475-69-8(CAS DataBase Reference)
FDA UNII 15K99VDU5F

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
NFPA 704
0
4 0

Beraprost sodium price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1737 Beraprost sodium ≥98% (HPLC) 88475-69-8 1MG $135 2023-06-20 Buy
Sigma-Aldrich SML1737 Beraprost sodium ≥98% (HPLC) 88475-69-8 5MG $542 2023-06-20 Buy
Cayman Chemical 18230 Beraprost (sodium salt) ≥98% 88475-69-8 1mg $135 2024-03-01 Buy
Cayman Chemical 18230 Beraprost (sodium salt) ≥98% 88475-69-8 5mg $540 2024-03-01 Buy
Cayman Chemical 18230 Beraprost (sodium salt) ≥98% 88475-69-8 10mg $945 2024-03-01 Buy
Product number Packaging Price Buy
SML1737 1MG $135 Buy
SML1737 5MG $542 Buy
18230 1mg $135 Buy
18230 5mg $540 Buy
18230 10mg $945 Buy

Beraprost sodium Chemical Properties,Uses,Production

Description

Beraprost sodium is a new, orally active antithrombotic epoprostenol analog introduced as a treatment for peripheral vascular disease, including Raynaud's syndrome and Buerger's disease. The antiplatelet activity may be due to its elevation of cyclic AMP in platelets which is achieved by activating adenylate cyclase in the platelet membrane, followed by the inhibition ofCa++- influx and thromboxane A2 formation.

Description

Beraprost is an analog of prostacyclin in which the unstable enol-ether has been replaced by a benzofuran ether function. This modification increases the plasma half-life from 30 seconds to several hours, and permits the compound to be taken orally. Doses of 20-100 μg in humans, given 1 to 3 times per day, have been demonstrated to improve clinical end points in diseases responsive to prostacyclin. Oral beraprost therapy improved the survival and pulmonary hemodynamics of patients with primary pulmonary hypertension. Beraprost inhibits platelet aggregation in healthy subjects and in diabetic patients at similar doses.

Chemical Properties

White Solid

Originator

Toray (Japan)

Uses

Platelet aggregation inhibitor; stable analog of Prostacyclin. Antithrombotic; vasodilator (peripheral).

Definition

ChEBI: Beraprost sodium is the organic sodium salt of beraprost. It is used in the treatment of chronic arterial occlusive disease and primary pulmonary hypertension in Japan. It has a role as an antihypertensive agent, a platelet aggregation inhibitor, a prostaglandin receptor agonist, a vasodilator agent and an anti-inflammatory agent. It contains a beraprost(1-).

brand name

Dorner; Dorner;Procylin

General Description

Beraprost sodium is an orally active prostacyclin analog.

Biochem/physiol Actions

Beraprost sodium is used as a therapeutic agent for chronic artery obstructions or primary pulmonary hypertension. In individuals with coronary artery disease, beraprost sodium helps to reduce oxidative stress and developed forearm endothelium dependent vasodilation.

Side effects

Disease-related events had similar incidence in patients receiving beraprost and those receiving placebo. Drug-related adverse events like headache, flushing, jaw pain, and diarrhea were more common in patients treated with beraprost sodium and occurred mostly during the six-week titration period. The incidence was markedly reduced in the maintenance period. Six patients (9%) in the beraprost sodium group and two (3%) in the placebo group withdrew prematurely from the study because of adverse events. No clinically adverse changes in hematologic or biochemical variables were seen in the beraprost sodium group.

Beraprost sodium Preparation Products And Raw materials

Raw materials

Preparation Products

Beraprost sodium Suppliers

Global( 133)Suppliers
Supplier Tel Email Country ProdList Advantage
Beijing Hope Pharmaceutical Co., Ltd.
+86-010-67886402 +8613611125266 market@hopelife.cn China 71 58
Hebei Weimiao Import and Export Trade Co., Ltd. 		+undefined19948166995 sale01@hbweimiao.com China 73 58
Shanghai Getian Industrial Co., LTD 		+86-15373193816 +86-15373193816 mike@ge-tian.com China 274 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21688 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9341 55
Shanghai finete Pharmaceutical Co., Ltd. 		+86-18221039705 CHINA 139 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22968 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Supplier Advantage
Beijing Hope Pharmaceutical Co., Ltd.
58
Hebei Weimiao Import and Export Trade Co., Ltd. 		58
Shanghai Getian Industrial Co., LTD 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55
Shanghai finete Pharmaceutical Co., Ltd. 		55
career henan chemical co 		58
Hubei xin bonus chemical co. LTD 		58
BOC Sciences 		58
Chongqing Chemdad Co., Ltd 		58

View Lastest Price from Beraprost sodium manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Beraprost sodium pictures 2024-05-15 Beraprost sodium
88475-69-8
 US $21.00 / box 1box 99% 10000box Shanghai Getian Industrial Co., LTD
Beraprost Sodium pictures 2024-04-23 Beraprost Sodium
88475-69-8
 US $40.00-36.00 / kg 1kg 99% 200000 Hebei Weimiao Import and Export Trade Co., Ltd.
Beraprost sodium pictures 2022-01-14 Beraprost sodium
88475-69-8
 US $0.00 / KG 1KG 98.9% 100 tons Honest Joy Holdings Limited
  • Beraprost sodium pictures
  • Beraprost sodium
    88475-69-8
  • US $21.00 / box
  • 99%
  • Shanghai Getian Industrial Co., LTD
  • Beraprost Sodium pictures
  • Beraprost Sodium
    88475-69-8
  • US $40.00-36.00 / kg
  • 99%
  • Hebei Weimiao Import and Export Trade Co., Ltd.

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beraprostsodium ML 1129 PROCYLIN TRK 100 2,3,3A-8B-TETRAHYDRO-2-HYDROXY-1-(3-HYDROXY-4-METHYL-1-OCTEN-6-YNYL)-1H-CYCLOPENTA[B]BENZOFURAN-5-BUTANOIC ACID, SODIUM SALT 1H-Cyclopenta[b]benzofuran-5-butanoic acid, 2,3,3a,8b-tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyl-1-octen-6-ynyl)-, monosodium salt Dorner MDL 201129 dl-4-[(1R,2R,3aS,8bS)-2,3,3a,8b-Tetrahydro-2-hydroxy-[(3S,4RS)-3-hydroxy-4-Methyl-oct-6-yne-(E)-1-enyl]-5-cyclopenta[b]benzofuranyl]butanoic Acid SodiuM Berasus Careload Sodium 2,3,3a-8b-tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyl-1-octen-6-ynyl)-1H-cyclopenta[b]benzofuran-5-butanoate Befraprost Unii-15K99vdu5f Beraprost sodium###Beraprost Procyclin 2,3,3a,8b-Tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyl-1-octen-6-yn-1-yl)-1H-cyclopenta[b]benzofuran-5-butanoic acid sodium salt Beprostaglandin sodium sodium 4-[2-hydroxy-1-[(E)-3-hydroxy-4-methyloct-1-en-6-ynyl]-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-5-yl]butanoate Beraprost sodium USP/EP/BP BERAPROST SODIUM SALT Sodium (E)-4-(2-hydroxy-1-(3-hydroxy-4-methyloct-1-en-6-yn-1-yl)-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-5-yl)butanoate (Beraprost Impurity) Sodium 4-(2-hydroxy-1-(3-hydroxy-4-methyloct-1-en-6-yn-1-yl)-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-5-yl)butanoate Beraprost sodium impurity sodium,4-[2-hydroxy-1-[(E)-3-hydroxy-4-methyloct-1-en-6-ynyl]-2,3,3a,8b-tetrahydro-1H-cyclopenta[b][1]benzofuran-5-yl]butanoate 88475-69-8 C24H29O5Na C24H29NaO5 Prostaglandin Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Prostaglandins