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ChemicalBook >> CAS DataBase List >>4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE

4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE

4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE Structure
4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE structure
CAS No.
171745-13-4
Chemical Name:
4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE
Synonyms
COMPOUND 56;N-(3-Bromophenyl)-6,7-diethoxy-4-quinazolinamine;N-(3-broMophenyl)-6,7-diethoxyquinazolin-4-aMine;4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE;4-Quinazolinamine, N-(3-bromophenyl)-6,7-diethoxy-
CBNumber:
CB8784430
Molecular Formula:
C18H18BrN3O2
Molecular Weight:
388.26
MDL Number:
MFCD01074974
MOL File:
Mol file
Last updated:2023-06-08 09:01:53
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4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE Properties

storage temp. Store at -20°C
solubility insoluble in H2O; ≥16.95 mg/mL in DMSO; ≥47.6 mg/mL in EtOH with ultrasonic
form White to off-white powder.

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Warning

4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 17254 Compound 56 ≥95% 171745-13-4 500μg $238 2024-03-01 Buy
Cayman Chemical 17254 Compound 56 ≥95% 171745-13-4 1mg $452 2024-03-01 Buy
AK Scientific 0335CA N-(3-Bromophenyl)-6,7-diethoxyquinazolin-4-amine 171745-13-4 1mg $600 2021-12-16 Buy
ApexBio Technology A8197 Compound56 171745-13-4 1unit $28 2021-12-16 Buy
ApexBio Technology A8197 Compound56 171745-13-4 500ug $50 2021-12-16 Buy
Product number Packaging Price Buy
17254 500μg $238 Buy
17254 1mg $452 Buy
0335CA 1mg $600 Buy
A8197 1unit $28 Buy
A8197 500ug $50 Buy

4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE Chemical Properties,Uses,Production

Uses

Compound 56 is a potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor.

Biological Activity

compound 56, 4-[(3-bromophenyl)amino]-6,7-diethoxyquinazoline, is a potent and specific inhibitor of the tyrosine kinase of the epidermal growth factor receptor (egfr) showing an ic50 of 0.006 nm. it competitively binds at the adenosine-triphosphate (atp) site of egfr. compound 56 is capable of inhibiting the phosphorylation of egf-dependent egfr, suppressing the proliferation and clonogenicity of a wide panel of egfr-overexpressing human cancer lines, and blocking egf-mediated mitogenesis and oncogenic transformation in fibroblasts overexpressing egfr. besides inhibiting egfr tyrosine kinase, it also inhibits the tyrosine kinase of human epidermal growth factor receptor 2 (her2/neu) but with a less potency.bridges aj, zhou h, cody dr, rewcastle gw, mcmichael a, showalter hd, fry dw, kraker aj, and denny wa. tyrosine kinase inhibitors. 8. an unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (pd 153035), a potent inhibitor of the epidermal growth factor receptor.j med chem 1966; 39 (1): 267-276monique bos, jhn mendelsohn, young-mee kim, joan albanell, david w. fry, and jose baelga. pd153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner. clin cancer res 1997;3:2099-2106

target

EGFR

4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE Suppliers

Global( 52)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 52927 58
AdooQ BioScience, LLC +1 (866) 930-6790 info@adooq.com United States 2784 58
ApexBio Technology LLC +1-832-696-8203 info@apexbt.com United States 477 60
CEG Chemical Science&Technology Co., Ltd. Mobile:13665161512 China 1785 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9709 58
Shanghai Rechem science Co., Ltd. 21-31433387 15618786686 sales@rechemscience.com China 2983 58
Wuxi Donghe Pharmaceutical Technology Co., Ltd. 63313187 15358055255 63313187@qq.com China 1974 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8141 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 4030 58
Supplier Advantage
Aladdin Scientific 		58
AdooQ BioScience, LLC 58
ApexBio Technology LLC 60
CEG Chemical Science&Technology Co., Ltd. 58
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai Rechem science Co., Ltd. 58
Wuxi Donghe Pharmaceutical Technology Co., Ltd. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
MedBioPharmaceutical Technology Inc 58
Nantong QuanYi Biotechnology Co., Ltd 58

4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE Spectrum

4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE(171745-13-4)MS

171745-13-4(4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE)Related Search:

TYRPHOSTIN B48 2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]- PD168393 TYRPHOSTIN A51 AG 213
CIVENTICHEM CV-409 AG 1478 HYDROCHLORIDE DAPH AG 18 LAVENDUSTIN A
METHYL 2,5-DIHYDROXYCINNAMATE H-ARG-ARG-LEU-ILE-GLU-ASP-ASN-GLU-TYR-THR-ALA-ARG-GLY-OH AG 825 TYRPHOSTIN A25 Canertinib

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COMPOUND 56 4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE N-(3-broMophenyl)-6,7-diethoxyquinazolin-4-aMine N-(3-Bromophenyl)-6,7-diethoxy-4-quinazolinamine 4-Quinazolinamine, N-(3-bromophenyl)-6,7-diethoxy- 171745-13-4 Inhibitor