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Efaproxiral

Efaproxiral structure

CAS No.: 131179-95-8

Chemical Name:: Efaproxiral

Synonyms: Efaproxyn;faproxiral;Efaproxiral;EFAPROXIRALUM;Efaproxiral (RSR13);Efaproxiral free acid;EFAPROXIRAL;EFAPROXIRAL FREE ACID;FAPROXIRAL;2-[4-(3,5-Dimethylphenylcarbamoylmethyl)phenoxy]-2-methylpropionic acid;2-(4-(((3,5-dimethylanilino)carbonyl)methyl)phenoxy)-2-methylpropionic acid;Propanoic acid, 2-[4-[2-[(3,5-dimethylphenyl)amino]-2-oxoethyl]phenoxy]-2-methyl-

CBNumber:: CB91359078

Molecular Formula:: C20H22NO4.Na

Molecular Weight:: 341.4

MDL Number:: MFCD00899086

MOL File:: 131179-95-8.mol

MSDS File:: SDS

Last updated:2023-06-08 09:03:09

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Efaproxiral Properties

Melting point	48-50°C
Boiling point	554.5±50.0 °C(Predicted)
Density	1.202±0.06 g/cm3(Predicted)
storage temp.	Refrigerator
solubility	DMSO (Slightly), Methanol (Slightly)
pka	3.26±0.10(Predicted)
form	Solid
color	Off-White to Tan
FDA UNII	J81E81G364
NCI Dictionary of Cancer Terms	efaproxiral
NCI Drug Dictionary	efaproxiral
ATC code	L01XD06

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312-P330-P501

NFPA 704

	0
2		0

Efaproxiral price More Price(12)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	28294	Efaproxiral	131179-95-8	100mg	$68	2024-03-01	Buy
Cayman Chemical	28294	Efaproxiral	131179-95-8	1g	$535	2024-03-01	Buy
Cayman Chemical	28294	Efaproxiral	131179-95-8	250mg	$161	2024-03-01	Buy
Cayman Chemical	28294	Efaproxiral	131179-95-8	500mg	$302	2024-03-01	Buy
TRC	E415000	Efaproxiral	131179-95-8	250mg	$175	2021-12-16	Buy

Product number	Packaging	Price	Buy
28294	100mg	$68	Buy
28294	1g	$535	Buy
28294	250mg	$161	Buy
28294	500mg	$302	Buy
E415000	250mg	$175	Buy

Efaproxiral Chemical Properties,Uses,Production

Description

Efaproxiral is an allosteric hemoglobin (Hb) modifier that reduces the affinity of Hb for oxygen, increasing the diffusion of oxygen from blood to tissue. In isolated human whole blood, efaproxiral (1.75 mM) increases the partial pressure of oxygen at which Hb is 50% saturated (p50) from 26.75 to 38.63 mm Hg and decreases the percent oxyhemoglobin (Hb-O₂) saturation from 48 to 33.8% at a partial oxygen pressure (pO₂) of 26 mm Hg. Efaproxiral (150 mg/kg) increases tumor pO₂ from 5.2 to 13.1 mm Hg 30 minutes after administration in a RIF-1 mouse fibrosarcoma flank tumor model. Efaproxiral (100 μM) enhances radiation-induced cytotoxicity in EMT6 mouse breast cancer cells grown under hypoxic conditions and increases radiosensitization and inhibits tumor growth in a hypoxic Lewis lung tumor mouse model when administered at a dose of 100 mg/kg. It also increases the running capacity of normal mice and mice with left coronary artery (LCA) ligation-induced myocardial infarction (MI) when administered at a dose of 150 mg/kg.

Chemical Properties

Off-White to Tan Solid

Uses

Allosteric modifier of hemoglobin (HB). Binds in the central water cavity of the Hb molecule causing a conformational change such that bound oxygen is released more readily. Antineoplastic adjunct (radiosensitizer).

Efaproxiral synthesis

Synthesis of Efaproxiral from 4-Hydroxyphenylacetic acid

Efaproxiral Preparation Products And Raw materials

Raw materials

Benzeneacetyl chloride, 4-hydroxy- N-(3,5-DIMETHYLPHENYL)-2-(4-HYDROXYPHENYL)ACETAMIDE 4-Hydroxyphenylacetic acid 3,5-Dimethylaniline Acetone

Chloroform 2-Bromo-2-methylpropionic acid

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Preparation Products

Efaproxiral Suppliers

Global( 68)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Xiamen AmoyChem Co., Ltd	+86-592-6051114 +8618959220845	sales@amoychem.com	China	6387	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17367	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418684 +8618949823763	sales@tnjchem.com	China	25363	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58

Supplier	Advantage
Xiamen AmoyChem Co., Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
SIMAGCHEM CORP	58
TargetMol Chemicals Inc.	58
InvivoChem	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
LEAPCHEM CO., LTD.	58

View Lastest Price from Efaproxiral manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-05	Efaproxiral 131179-95-8	US $1.00 / KG	1KG	95--99%	1ton	Career Henan Chemical Co

Efaproxiral
131179-95-8
US $1.00 / KG
95--99%
Career Henan Chemical Co

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2-methyl-2-(4-methylphenoxy)propanoic acid 2-(4-HYDROXY-PHENYL)-N-PHENYL-ACETAMIDE 4-METHOXY-N-PHENYL-BENZENEETHANAMINE

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2-(4-(((3,5-dimethylanilino)carbonyl)methyl)phenoxy)-2-methylpropionic acid Efaproxiral Efaproxiral free acid faproxiral EFAPROXIRALUM 2-[4-(3,5-Dimethylphenylcarbamoylmethyl)phenoxy]-2-methylpropionic acid EFAPROXIRAL;EFAPROXIRAL FREE ACID;FAPROXIRAL Propanoic acid, 2-[4-[2-[(3,5-dimethylphenyl)amino]-2-oxoethyl]phenoxy]-2-methyl- Efaproxiral (RSR13) Efaproxyn 131179-95-8 C20H22NO4Na Amines Aromatics Intermediates & Fine Chemicals Pharmaceuticals