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DICUMAROL

DICUMAROL
DICUMAROL structure
CAS No.
66-76-2
Chemical Name:
DICUMAROL
Synonyms
Cuma;Cumid;nc034;Acadyl;Acavyl;Dicuman;Dicumol;Kumoran;Dicoumal;Dufalone
CBNumber:
CB9224757
Molecular Formula:
C19H12O6
Formula Weight:
336.29
MOL File:
66-76-2.mol

DICUMAROL Properties

Melting point:
290-292 °C(lit.)
Boiling point:
392.79°C (rough estimate)
Density 
1.2864 (rough estimate)
refractive index 
1.4450 (estimate)
storage temp. 
+2C to +8C
form 
Fine Crystalline Powder
color 
White
Water Solubility 
Soluble in aqueous alkaline solutions, organic bases, 0.1 N NaOH (15 mg/ml), Pyridine (50 mg/ml), chloroform (slightly soluble), and benzene (slightly soluble). Insoluble in water, and alcohols.
Merck 
14,3090
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T,N
Risk Statements  22-48/25-51/53
Safety Statements  37-45-61
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  GN7875000
TSCA  Yes
HazardClass  6.1(b)
PackingGroup  III
HS Code  29322985
Toxicity LD50 orally in rats: 541.6 mg/kg (Rose)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger P260, P264, P270, P314, P501
H411 Toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 2
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P314 Get medical advice/attention if you feel unwell.

DICUMAROL price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich M1390 3,3′-Methylene-bis(4-hydroxycoumarin) 66-76-2 5g $40.4 2018-11-13 Buy
Sigma-Aldrich 287897 Dicoumarol 66-76-2 500mg $64.4 2018-11-20 Buy
Alfa Aesar J63634 Dicumarol 66-76-2 25g $67.7 2018-11-13 Buy
Alfa Aesar J63634 Dicumarol 66-76-2 5g $29.5 2018-11-13 Buy
Cayman Chemical 20764 Dicoumarol ≥98% 66-76-2 5g $30 2018-11-19 Buy

DICUMAROL Chemical Properties,Uses,Production

Chemical Properties

white fine crystalline powder

Uses

anticoagulant

Definition

ChEBI: A hydroxycoumarin that is methane in which two hydrogens have each been substituted by a 4-hydroxycoumarin-3-yl group.

General Description

Dicumarol, 3,3'-methylenebis[4-hydroxycoumarin],is a white or creamy white crystalline powderwith a faint, pleasant odor and a slightly bitter taste. It ispractically insoluble in water or alcohol, slightly soluble inchloroform, and dissolved readily by solutions of fixed alkalies.The effects after administration require 12 to 72 hours todevelop and persist for 24 to 96 hours after discontinuance.

Clinical Use

Dicumarol is used alone or as an adjunct to heparin in theprophylaxis and treatment of intravascular clotting. It is usedin postoperative thrombophlebitis, pulmonary embolus, acuteembolic and thrombotic occlusion of peripheral arteries, andrecurrent idiopathic thrombophlebitis. It has no effect on analready-formed embolus but may prevent further intravascularclotting. Because the outcome of acute coronary thrombosisdepends largely on extension of the clot and formation ofmural thrombi in the heart chambers, with subsequent embolization,dicumarol has been used in this condition. It hasalso been administered to arrest impending gangrene afterfrostbite. The dose, after determination of the prothrombinclotting time, is 25 to 200 mg, depending on the size and thecondition of the patient. The drug is given orally in the formof capsules or tablets. On the second day and thereafter, itmay be given in amounts sufficient to maintain the prothrombinclotting time at about 30 seconds. If hemorrhages shouldoccur, a dosage of 50 to 100 mg of menadione sodium bisulfiteis injected, supplemented by a blood transfusion.

DICUMAROL Preparation Products And Raw materials

Raw materials

Preparation Products


DICUMAROL Suppliers

Global( 88)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
Hubei Jusheng Technology Co.,Ltd.
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peter@hubeijusheng.com CHINA 20095 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40277 62
Energy Chemical 021-58432009 / 400-005-6266
021-58436166-800 info@energy-chemical.com China 44046 61
Beijing Ouhe Technology Co., Ltd +86-10-4006331231;+86-10-51280831;+86-10-82967028
+86-10-82967029 sales@ouhechem.com China 12500 60
LGM Pharma 1-(800)-881-8210
615-250-9817 inquiries@lgmpharma.com United States 1943 70
Tianjin heowns Biochemical Technology Co., Ltd. 400 638 7771
sales@heowns.com China 14464 57
ShangHai YuanYe Biotechnology Co., Ltd. 021-61312847 qq:2797782341
021-55068248 2797782341@qq.com China 7571 60
Shanghai LiuShi Pharmaceutical Technology Co., Ltd. 021-60135539
021-38721356 shlschemical@hotmail.com China 9916 55

DICUMAROL Spectrum


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