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DICUMAROL structure
Chemical Name:
Molecular Formula:
Formula Weight:
MOL File:

DICUMAROL Properties

Melting point:
290-292 °C(lit.)
Boiling point:
392.79°C (rough estimate)
1.2864 (rough estimate)
refractive index 
1.4450 (estimate)
storage temp. 
+2C to +8C
Fine Crystalline Powder
Water Solubility 
Soluble in aqueous alkaline solutions, organic bases, 0.1 N NaOH (15 mg/ml), Pyridine (50 mg/ml), chloroform (slightly soluble), and benzene (slightly soluble). Insoluble in water, and alcohols.
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T,N
Risk Statements  22-48/25-51/53
Safety Statements  37-45-61
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  GN7875000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29322985
Toxicity LD50 orally in rats: 541.6 mg/kg (Rose)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger P260, P264, P270, P314, P501
H411 Toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 2
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P314 Get medical advice/attention if you feel unwell.

DICUMAROL price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich M1390 3,3′-Methylene-bis(4-hydroxycoumarin) 66-76-2 5g $40.4 2018-11-13 Buy
Sigma-Aldrich 287897 Dicoumarol 66-76-2 500mg $64.4 2018-11-20 Buy
Alfa Aesar J63634 Dicumarol 66-76-2 25g $67.7 2018-11-13 Buy
Alfa Aesar J63634 Dicumarol 66-76-2 5g $29.5 2018-11-13 Buy
Cayman Chemical 20764 Dicoumarol ≥98% 66-76-2 5g $30 2018-11-19 Buy

DICUMAROL Chemical Properties,Uses,Production

Chemical Properties

white fine crystalline powder




ChEBI: A hydroxycoumarin that is methane in which two hydrogens have each been substituted by a 4-hydroxycoumarin-3-yl group.

General Description

Dicumarol, 3,3'-methylenebis[4-hydroxycoumarin],is a white or creamy white crystalline powderwith a faint, pleasant odor and a slightly bitter taste. It ispractically insoluble in water or alcohol, slightly soluble inchloroform, and dissolved readily by solutions of fixed alkalies.The effects after administration require 12 to 72 hours todevelop and persist for 24 to 96 hours after discontinuance.

Clinical Use

Dicumarol is used alone or as an adjunct to heparin in theprophylaxis and treatment of intravascular clotting. It is usedin postoperative thrombophlebitis, pulmonary embolus, acuteembolic and thrombotic occlusion of peripheral arteries, andrecurrent idiopathic thrombophlebitis. It has no effect on analready-formed embolus but may prevent further intravascularclotting. Because the outcome of acute coronary thrombosisdepends largely on extension of the clot and formation ofmural thrombi in the heart chambers, with subsequent embolization,dicumarol has been used in this condition. It hasalso been administered to arrest impending gangrene afterfrostbite. The dose, after determination of the prothrombinclotting time, is 25 to 200 mg, depending on the size and thecondition of the patient. The drug is given orally in the formof capsules or tablets. On the second day and thereafter, itmay be given in amounts sufficient to maintain the prothrombinclotting time at about 30 seconds. If hemorrhages shouldoccur, a dosage of 50 to 100 mg of menadione sodium bisulfiteis injected, supplemented by a blood transfusion.

DICUMAROL Preparation Products And Raw materials

Raw materials

Preparation Products


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