PF-622
- CAS No.
- 898235-65-9
- Chemical Name:
- PF-622
- Synonyms
- PF-622;FAAH Inhibitor, PF-622;N-phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carboxamide;1-Piperazinecarboxamide, N-phenyl-4-(2-quinolinylmethyl)-
- CBNumber:
- CB92454224
- Molecular Formula:
- C21H22N4O
- Molecular Weight:
- 346.43
- MDL Number:
- MFCD10567108
- MOL File:
- 898235-65-9.mol
PF-622 price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10010907 | PF-622 >98% | 898235-65-9 | 1mg | $25 | 2024-03-01 | Buy |
| Cayman Chemical | 10010907 | PF-622 >98% | 898235-65-9 | 5mg | $107 | 2024-03-01 | Buy |
| Cayman Chemical | 10010907 | PF-622 >98% | 898235-65-9 | 10mg | $186 | 2024-03-01 | Buy |
| Cayman Chemical | 10010907 | PF-622 >98% | 898235-65-9 | 50mg | $807 | 2024-03-01 | Buy |
| ApexBio Technology | C4756 | PF-622 | 898235-65-9 | 50mg | $922 | 2021-12-16 | Buy |
PF-622 Chemical Properties,Uses,Production
Description
PF-622 (898235-65-9) is a potent and selective irreversible FAAH inhibitor. Covalently modifies active site-serine (IC50=33 nM). Completely selective for FAAH relative to other mammalian serine hydrolases. Cell permeable
Uses
PF-622 is a selective FAAH inhibitor, and can be used for study of analgesic and anxiolytic/antidepressant[1].
in vitro
pf-622 inhibited the activity of faah in a time-dependent manner with the ic50 values of 0.99 and 0.033 μm in human recombinant faah for 5 and 60 minutes, respectively [1]. in various human and murine tissue proteome samples, pf-622 showed highly selectivity for faah in relative to other serine hydrolases, showing no discernable off-site activity up to 500 μm [1]. pf-622 at 1 μm decreased il-2 production in both healthy subjects and in hcv patients [2].
References
1) Ahn et al. (2007), Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity; Biochemistry, 46 13019
PF-622 Preparation Products And Raw materials
Raw materials
Preparation Products
PF-622 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8140 | 58 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 4971 | 58 |
| Chengdu Peter-like Biotechnology Co., Ltd. | 028-81700200 13308200041 | 2851167782@qq.com | China | 11183 | 58 |
| Enzo Biochem Inc | Enzo Biochem Inc. 13797054060 | Enzoname@qq.com | China | 124812 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6251 | 58 |