ChemicalBook >> CAS DataBase List >>lumateperone (Tosylate)
lumateperone (Tosylate)
- CAS No.
- 1187020-80-9
- Chemical Name:
- lumateperone (Tosylate)
- Synonyms
- Lumateperone, Caplyta;ITI 007;ITI007 tosylate;ITI722 tosylate;ITI 007 tosylate;ITI 722 tosylate;ITI-007 tosylate;ITI-722 tosylate;Lumateperone(ITI-007);Lumateperone PTSA salt
- CBNumber:
- CB93121116
- Molecular Formula:
- C31H36FN3O4S
- Molecular Weight:
- 565.7
- MDL Number:
- MFCD29922434
- MOL File:
- 1187020-80-9.mol
Last updated:2024-03-21 10:10:58
| storage temp. | Store at -20°C |
|---|---|
| solubility | DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:7): 0.12 mg/ml; DMSO: 10 mg/ml; Ethanol: 1 mg/ml |
| form | A solid |
| InChIKey | LHAPOGAFBLSJJQ-HXLBOWIHNA-N |
| SMILES | S(C1C=CC(C)=CC=1)(O)(=O)=O.CN1CCN2[C@@]3([H])CCN(CCCC(C4C=CC(F)=CC=4)=O)C[C@@]3([H])C3=CC=CC1=C32 |&1:16,34,r| |
| FDA UNII | JIE88N006O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H336-H361f |
| Precautionary statements | P202-P261-P271-P280-P304+P340+P312-P308+P313 |
lumateperone (Tosylate) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2866 | Lumateperone tosylate ≥98% (HPLC) | 1187020-80-9 | 10MG | $107 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML2866 | Lumateperone tosylate ≥98% (HPLC) | 1187020-80-9 | 50MG | $430 | 2024-03-01 | Buy |
| Biosynth Carbosynth | BL167386 | Lumateperone tosylate | 1187020-80-9 | 10mg | $175 | 2021-12-16 | Buy |
| ChemScene | CS-5540 | Lumateperone tosylate 99.42% | 1187020-80-9 | 10mg | $180 | 2021-12-16 | Buy |
| AK Scientific | 2943DF | Lumateperone tosylate | 1187020-80-9 | 10mg | $286 | 2021-12-16 | Buy |
lumateperone (Tosylate) Chemical Properties,Uses,Production
Uses
lumateperone (Tosylate) is a new second-generation antipsychotic indicated for treating schizophrenia that can potentially alleviate positive and negative symptoms. This drug interacts with dopamine, serotonin, and glutamate, making it unique compared to other antipsychotics. Its highly selective nature for D2R receptors in specific brain regions decreases unfavorable adverse effects and makes it a safer drug[1].
Biochem/physiol Actions
Lumateperone tosylate (ITI-007) is an orally active, potent 5-HT2A antagonist, postsynaptic D2 antagonist, and serotonin transporter SERT inhibitor (Ki = 0.5, 32, 62 nM, respectively) with in vivo antipsychotic efficacy and no effect toward receptors associated with cognitive and metabolic side effects of antipsychotic drugs (e.g., H1, 5-HT2C, muscarinic). ITI-007 blocks DOI-induced headtwitch (ID50 = 0.09 mg/kg, po.) and D-AMPH-induced hyperlocomotion in mice (ID50 = 0.95 mg/kg, po.), while also acting as a partial agonist at presynaptic striatal D2 receptors.
References
[1] Kunal Maini. “Lumateperone tosylate, A Selective and Concurrent Modulator of Serotonin, Dopamine, and Glutamate, in the Treatment of Schizophrenia.” Health Psychology Research (2021): 24932.
lumateperone (Tosylate) Preparation Products And Raw materials
Raw materials
Preparation Products
lumateperone (Tosylate) Suppliers
Global( 112)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Aupone Pharmaceutical Co.Ltd. | +86-28-+86-28-87843998-6060-6060 +8618631098571 | lijiaqi@aupone.com | China | 43 | 58 |
| Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 | sales@fine-chemtech.com | CHINA | 885 | 55 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Shanghai Jinghao Pharmaceutical Co.,Ltd | +86-21-68900963 | sales@jinghaopharma.com | CHINA | 153 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
| Shanghai Innopharm Industrial Co., Ltd. | +86-21-59960785 +86-17701845089 | sales@hoyaopharm.com | China | 261 | 58 |
View Lastest Price from lumateperone (Tosylate) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-03-15 | Lumateperone Tosylate
1187020-80-9
|
US $0.00 / gram | 5gram | 99.99% | 1Tons/year | Chengdu Aupone Pharmaceutical Co.Ltd. | |
 |
2023-11-01 | lumateperone (Tosylate)
1187020-80-9
|
US $16000.00 / g | 1g | 99.0%min singleimpurity 0.5%max | 50KG | Hangzhou ICH Biofarm Co., Ltd | |
 |
2022-03-11 | lumateperone (Tosylate)
1187020-80-9
|
US $1.10 / g | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited |
-
- Lumateperone Tosylate
1187020-80-9
- US $0.00 / gram
- 99.99%
- Chengdu Aupone Pharmaceutical Co.Ltd.
-
- lumateperone (Tosylate)
1187020-80-9
- US $16000.00 / g
- 99.0%min singleimpurity 0.5%max
- Hangzhou ICH Biofarm Co., Ltd
-
- lumateperone (Tosylate)
1187020-80-9
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
1187020-80-9(lumateperone (Tosylate))Related Search:
1-(4-Fluorophenyl)-4-[(6bR,10aS)-2,3,6b,9,10,10a-hexahydro-3-methyl-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl]-1-butanone 4-methylbenzenesulfonate (1:1)
Lumateperone(ITI-007)
lumateperone (Tosylate)
ITI 007
ITI-007;ITI 007;ITI007;LUMATEPERONE;1187020-80-9
ITI-722; ITI722; ITI 722; ITI-007; ITI007; ITI 007; LUMATEPERONE, CAPLYTA,
lumateperone (Tosylate) ISO 9001：2015 REACH
Lumateperone toluenesulfonic acid (PTSA salt)
Lumateperone, Caplyta
Lumateperone PTSA salt
Dopamine Receptor,ITI007,schizophrenia,lumateperone Tosylate,Inhibitor,inhibit,dopamine D1 receptor,5-HT2A,5-hydroxytryptamine Receptor,presynaptic D2 receptor,5-HT Receptor,Lumateperone,ITI 007,postsynaptic D2 receptor,Serotonin Receptor
1-(4-Fluorophenyl)-4-((6bR,10aS)-3-methyl-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(9H)-yl)butan-1-one 4-methylbenzenesulfonate
Lumateperone P-toluenesulfonate Salt
ITI 007 tosylate
ITI 722 tosylate
ITI007 tosylate
ITI-007 tosylate
ITI722 tosylate
ITI-722 tosylate
1-(4-Fluorophenyl)-4-((6bR,10aS)-3-methyl-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(9H)-yl)butan-1-one 4-methylbenzenesulfonate
1187020-80-9
C24H28FN3OC7H8O3S