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ML385

ML385 Structure
ML385 structure
CAS No.
846557-71-9
Chemical Name:
ML385
Synonyms
ML38;ML385;CS-2542;ML 385; ML-385;Ferroptosis,ML385,Inhibitor,inhibit,ML-385,Keap1-Nrf2,ML 385;N-[4-[2,3-Dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-1,3-benzodioxole-5-acetamide;1,3-Benzodioxole-5-acetamide, N-[4-[2,3-dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-;2-(1,3-benzodioxol-5-yl)-N-[5-methyl-4-[1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl]-1,3-thiazol-2-yl]acetamide
CBNumber:
CB93168748
Molecular Formula:
C29H25N3O4S
Molecular Weight:
511.59
MDL Number:
MFCD06616124
MOL File:
846557-71-9.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59
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ML385 Properties

Density 1.374±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO:31.4(Max Conc. mg/mL);61.38(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);58.64(Max Conc. mM)
DMF:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.49(Max Conc. mM)
form powder
pka 8.92±0.50(Predicted)
color white to beige

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

ML385 price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1833 ML385 ≥98% (HPLC) 846557-71-9 5MG $107 2023-06-20 Buy
Sigma-Aldrich SML1833 ML385 ≥98% (HPLC) 846557-71-9 25MG $434 2023-06-20 Buy
Cayman Chemical 21114 ML-385 ≥98% 846557-71-9 5mg $93 2024-03-01 Buy
Cayman Chemical 21114 ML-385 ≥98% 846557-71-9 10mg $176 2024-03-01 Buy
Cayman Chemical 21114 ML-385 ≥98% 846557-71-9 25mg $388 2024-03-01 Buy
Product number Packaging Price Buy
SML1833 5MG $107 Buy
SML1833 25MG $434 Buy
21114 5mg $93 Buy
21114 10mg $176 Buy
21114 25mg $388 Buy

ML385 Chemical Properties,Uses,Production

Biochem/physiol Actions

ML385 inihbits the activity of the Nrf2 transcription factor by binding to Neh1, a CNC-bZIP domain that allows Nrf2 to heterodimerize with small Maf proteins, blocking NRF2 transcriptional activity. Much research has been done on activating Nrf2 because it induces cytoprotective antioxidant genes. However, some cancer cells may use Nrf2 similarly for their survival. Nrf2 is overexpressed in certain cancers such as non-small cell lung cancer (NSCLC) often due to loss of function mutations in KEAP1, which targets Nrf2 for proteasomal degradation. ML385 was found to have anti-tumor activity with specificity and selectivity for NSCLC cells with KEAP1 mutations.

storage

Store at -20°C

ML385 Preparation Products And Raw materials

Raw materials

Preparation Products

ML385 Suppliers

Global( 88)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Career Henan Chemica Co 		+86-0371-86658258 15093356674; laboratory@coreychem.com China 30255 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894 shawn@hirisunpharm.com CHINA 9923 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3136 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8474 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		+86-18341751992 +86-15382112998 757984502@qq.com China 892 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 57511 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED
60
BOC Sciences 		58
Career Henan Chemica Co 		58
Hefei Hirisun Pharmatech Co., Ltd 		58
InvivoChem 		58
Nantong HI-FUTURE Biology Co., Ltd. 		58
TargetMol Chemicals Inc. 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		58
Aladdin Scientific 		58

ML385 Spectrum

ML385(846557-71-9)1HNMR

846557-71-9(ML385)Related Search:

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ML385 CS-2542 ML 385; ML-385 N-[4-[2,3-Dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-1,3-benzodioxole-5-acetamide 2-(1,3-benzodioxol-5-yl)-N-[5-methyl-4-[1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl]-1,3-thiazol-2-yl]acetamide 1,3-Benzodioxole-5-acetamide, N-[4-[2,3-dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]- Ferroptosis,ML385,Inhibitor,inhibit,ML-385,Keap1-Nrf2,ML 385 ML38 846557-71-9 api