2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile
- CAS No.
- 13600-42-5
- Chemical Name:
- 2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile
- Synonyms
- 3-Cyano-2,6-dichloro-4-(trifluoromethyl)pyridine, 2,6-Dichloro-4-(trifluoromethyl)pyridine-3-carbonitrile;BUTTPARK 43\57-39;IFLAB-BB F2108-0099;2,6-Dichloro-4-(Trifluoromethy;,6-Dichloro-4-(trifluoromethyl)nicotinonitrile;2,6-DICHLORO-4-(TRIFLUOROMETHYL)NICOTINONITRILE;3-Cyano-2,6-dichloro-4-(trifluoomethyl)pyridine;3-CYANO-2,6-DICHLORO-4-(TRIFLUOROMETHYL)PYRIDINE;2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile 98%;3-Cyano-2,6-dichloro-4-(trifluoromethyl)pyridine98%
- CBNumber:
- CB9351572
- Molecular Formula:
- C7HCl2F3N2
- Molecular Weight:
- 241
- MDL Number:
- MFCD00084977
- MOL File:
- 13600-42-5.mol
- MSDS File:
- SDS
| Melting point | 38 °C |
|---|---|
| Boiling point | 282.4±35.0 °C(Predicted) |
| Density | 1.63±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | crystals |
| pka | -6.82±0.10(Predicted) |
| color | Colourless |
| CAS DataBase Reference | 13600-42-5(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | T,Xi,Xn |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 22-26-36/37/39 |
| RIDADR | 3439 |
| HazardClass | TOXIC |
| HS Code | 2933399990 |
2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | C978900 | 3-Cyano-2,6-dichloro-4-trifluoromethylpyridine | 13600-42-5 | 10g | $140 | 2021-12-16 | Buy |
| TRC | C978900 | 3-Cyano-2,6-dichloro-4-trifluoromethylpyridine | 13600-42-5 | 25g | $275 | 2021-12-16 | Buy |
| TRC | C978900 | 3-Cyano-2,6-dichloro-4-trifluoromethylpyridine | 13600-42-5 | 50g | $495 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC55196 | 3-Cyano-2,6-dichloro-4-(trifluoromethyl)pyridine | 13600-42-5 | 10g | $250 | 2021-12-16 | Buy |
| Apolloscientific | PC2101D | 2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile 97% | 13600-42-5 | 25g | $263 | 2021-12-16 | Buy |
2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile Chemical Properties,Uses,Production
Chemical Properties
yellow powder
Uses
3-Cyano-2,6-dichloro-4-trifluoromethylpyridine is used as a reagent in the synthesis of cyano(trifluoromethyl)aminopyridine derivatives which are used as androgen receptor antagonists for stimulating hair growth and reducing sebum production. 3-Cyano-2,6-dichloro-4-trifluoromethylpyridine is also used in the preparation of novel analogs of marine indole alkaloids which are used as potential anticancer agents.
Synthesis
3335-46-4
13600-42-5
GENERAL STEPS: In a 500 mL round bottom flask, 84.5 g (414 mmol) of 2,6-dihydroxy-3-cyano-4-(trifluoromethyl)pyridine, 400 g of phosphoryl chloride and 35 g of catalyst were added. The mixture was heated and refluxed for 20 h, during which the progress of the reaction was monitored by TLC. Upon completion of the reaction, the reflux unit was changed to a distillation unit to evaporate the excess phosphorus trichloride. The reaction mixture was slowly poured into an ice-water mixture and a white solid was precipitated. The solid was collected by filtration and dried to give 79.6 g of the target product 2,6-dichloro-3-cyano-4-(trifluoromethyl)pyridine in 79.78% yield.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 4, p. 475 - 477
[2] Patent: CN107382848, 2017, A. Location in patent: Paragraph 0043; 0046-0047
2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29734 | 60 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Hangzhou Cyanochem Co., Ltd. | +86 17788583750 | sales@cyanochem.com | CHINA | 281 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29800 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10035 | 58 |
View Lastest Price from 2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-06-25 | 2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile
13600-42-5
|
US $1.10 / g | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2021-10-16 | 2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile
13600-42-5
|
US $10.00 / KG | 1KG | 99% | 20 Tons | Hebei Zhanyao Biotechnology Co. Ltd | |
 |
2019-12-31 | 2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile
13600-42-5
|
US $1.00 / KG | 1KG | 99% | 10000KGS | Career Henan Chemical Co |
-
- 2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile
13600-42-5
- US $1.10 / g
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- 2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile
13600-42-5
- US $10.00 / KG
- 99%
- Hebei Zhanyao Biotechnology Co. Ltd
-
- 2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile
13600-42-5
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
