5-Amino-4,6-dichloro-2-methylpyrimidine
- CAS No.
- 39906-04-2
- Chemical Name:
- 5-Amino-4,6-dichloro-2-methylpyrimidine
- Synonyms
- 4,6-DICHLORO-2-METHYLPYRIMIDIN-5-AMINE;TIMTEC-BB SBB003764;2-Methyl-4,6-dichloro-5-aminop;Methyl-4,6-dichloro-5-aminopyrimidine;4,6-dichloro-2-methyl-5-pyrimidinamine;5-AMINO-4,6-DICHLORO-2-METHYLPYRIMIDINE;2-METHYL-4,6-DICHLORO-5-AMINOPYRIMIDINE;5-Amino-4,6-Dichloro-2-Methylpytimidine;4,6-dichloro-2-Methyl-5-aMino-pyriMidine;5-Pyrimidinamine, 4,6-dichloro-2-methyl-
- CBNumber:
- CB9368291
- Molecular Formula:
- C5H5Cl2N3
- Molecular Weight:
- 178.02
- MDL Number:
- MFCD00194053
- MOL File:
- 39906-04-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 5-Amino-4,6-dichloro-2-methylpyrimidine 97% | 548235 | 10g | $119 |
| 5-Amino-4,6-dichloro-2-methylpyrimidine >98.0%(GC) | A1946 | 5g | $121 |
| 5-Amino-4,6-dichloro-2-methylpyrimidine >98.0%(GC) | A1946 | 25g | $481 |
| 5-Amino-4,6-dichloro-2-methylpyrimidine | A632035 | 50mg | $45 |
| 5-Amino-4,6-dichloro-2-methylpyrimidine | FA11120 | 25g | $60 |
| More product size | |||
| Melting point | 70-73 °C (lit.) |
|---|---|
| Boiling point | 257.7±35.0 °C(Predicted) |
| Density | 1.504±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | -2.55±0.39(Predicted) |
| color | White to Yellow to Green |
| InChI | InChI=1S/C5H5Cl2N3/c1-2-9-4(6)3(8)5(7)10-2/h8H2,1H3 |
| InChIKey | FKRXXAMAHOGYNT-UHFFFAOYSA-N |
| SMILES | C1(C)=NC(Cl)=C(N)C(Cl)=N1 |
| CAS DataBase Reference | 39906-04-2(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29335990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| NFPA 704 |
|
5-Amino-4,6-dichloro-2-methylpyrimidine price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 548235 | 5-Amino-4,6-dichloro-2-methylpyrimidine 97% | 39906-04-2 | 10g | $119 | 2023-06-20 | Buy |
| TCI Chemical | A1946 | 5-Amino-4,6-dichloro-2-methylpyrimidine >98.0%(GC) | 39906-04-2 | 5g | $121 | 2026-04-30 | Buy |
| TCI Chemical | A1946 | 5-Amino-4,6-dichloro-2-methylpyrimidine >98.0%(GC) | 39906-04-2 | 25g | $481 | 2026-04-30 | Buy |
| TRC | A632035 | 5-Amino-4,6-dichloro-2-methylpyrimidine | 39906-04-2 | 50mg | $45 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA11120 | 5-Amino-4,6-dichloro-2-methylpyrimidine | 39906-04-2 | 25g | $60 | 2021-12-16 | Buy |
5-Amino-4,6-dichloro-2-methylpyrimidine Chemical Properties,Uses,Production
Appearance
White to Yellow to Green powder to crystal
Uses
5-Amino-4,6-dichloro-2-methylpyrimidine is a useful research chemical for organic synthesis and other chemical and pharmacological processes.
Application
5-Amino-4,6-dichloro-2-methylpyrimidine can be used as an intermediate in medical synthesis, such as the preparation of mosonidine. Mosonidine is a widely used antihypertensive drug.
Synthesis
13162-43-1
39906-04-2
GENERAL METHOD: 10% Pd/C catalyst (0.05 g) was added to a solution of 4,6-dichloro-2-methyl-5-nitropyrimidine (4.48 mmol) in ethyl acetate (EA, 20 mL) in a Parr hydrogenation reactor. Subsequently, the air in the reactor was replaced with nitrogen three times and the hydrogenation reaction was carried out at room temperature and at atmospheric pressure. Upon completion of the reaction, the Pd/C catalyst was removed by diatomaceous earth filtration and the filtrate was concentrated to afford the intermediate 2-methyl-4,6-dichloro-5-aminopyrimidine (11a). The product was a light-colored solid, yield: 84.0%; mass spectrum (ESI) m/z: 177.94 [M + H]+.
References
[1] European Journal of Medicinal Chemistry, 2017, vol. 140, p. 212 - 228
[2] Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983, p. 1113 - 1115
[3] Khimiya Geterotsiklicheskikh Soedinenii, 1983, vol. 19, # 10, p. 1398 - 1400
[4] Journal of the Chemical Society, 1954, p. 3832,3833
[5] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 17, p. 5721 - 5726
5-Amino-4,6-dichloro-2-methylpyrimidine Preparation Products And Raw materials
Raw materials
1of4
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14304 | 58 |
| JUYE XIANDAI fine chemistry Co.,Ltd | +86-18958038633; +8618958038633 | tony@sdhypharma.com | China | 64 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20124 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21590 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29819 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2994 | 58 |
| Shanghai Worldyang Chemical Co.,Ltd. | +86-021-56795779 +8613651600618 | sales@worldyachem.com | China | 967 | 58 |
View Lastest Price from 5-Amino-4,6-dichloro-2-methylpyrimidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-04-30 | 5-Amino-4,6-dichloro-2-methylpyrimidine
39906-04-2
|
US $0.00-0.00 / Kg/Drum | 1KG | 98%min | 500kgs | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2025-09-25 | 5-Amino-4,6-dichloro-2-methylpyrimidine
39906-04-2
|
US $5.00-0.10 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2025-04-04 | 5-Amino-4,6-dichloro-2-methylpyrimidine
39906-04-2
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- 5-Amino-4,6-dichloro-2-methylpyrimidine
39906-04-2
- US $0.00-0.00 / Kg/Drum
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 5-Amino-4,6-dichloro-2-methylpyrimidine
39906-04-2
- US $5.00-0.10 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 5-Amino-4,6-dichloro-2-methylpyrimidine
39906-04-2
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
