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Cefaclor

Brand Name(s) in US
Cefaclor
Cefaclor
CAS No.
53994-73-3
Chemical Name:
Cefaclor
Synonyms
S 6472;Kefral;Alfacet;panoral;CEFACLOR;Cefachlor;Cephaclor;Cefaclorum;lilly99638;Cefaclor (Ceclor)
CBNumber:
CB9390436
Molecular Formula:
C15H14ClN3O4S
Formula Weight:
367.81
MOL File:
53994-73-3.mol

Cefaclor Properties

Density 
1.3575 (rough estimate)
refractive index 
1.6100 (estimate)
solubility 
1 M HCl: 50 mg/mL, clear to very faintly turbid, yellow
pka
pKa 1.5±0.2(H2O) (Uncertain)
form 
powder
BRN 
8176092
CAS DataBase Reference
53994-73-3(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,Xi
Risk Statements  42/43
Safety Statements  22-36/37-45
WGK Germany  2
RTECS  XI0363000
HS Code  29349990
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled Sensitisation, respiratory Category 1 Danger P261, P285, P304+P341, P342+P311,P501
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P284 Wear respiratory protection.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P342+P311 IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

Cefaclor price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 72579 Cefaclor analytical reference material 53994-73-3 50mg $71.6 2018-11-20 Buy
Sigma-Aldrich C6895 Cefaclor 53994-73-3 1g $200 2018-11-20 Buy
Alfa Aesar J64252 Cefaclor 53994-73-3 10g $305 2018-11-13 Buy
Alfa Aesar J64252 Cefaclor 53994-73-3 1g $71.1 2018-11-13 Buy
Sigma-Aldrich C6895 Cefaclor 53994-73-3 100mg $39.9 2018-11-20 Buy

Cefaclor Chemical Properties,Uses,Production

Brand Name(s) in US

Ceclor

Chemical Properties

white crystalline solid

Uses

Cefaclor belongs to the family of antibiotics known as the cephalosporins (cefalosporins). The cephalosporins are broad-spectrum antibiotics that are used for the treatment of septicaemia, pneumonia, meningitis, biliary-tract infections, peritonitis, and

Uses

radioopaque agent

Definition

ChEBI: A cephalosporin bearing chloro and (R)-2-amino-2-phenylacetamido groups at positions 3 and 7, respectively, of the cephem skeleton.

brand name

Ceclor (Lilly); Raniclor (Ranbaxy).

Antimicrobial activity

It is less resistant than other group 2 cephalosporins to staphylococcal β-lactamase. It is active against N. gonorrhoeae and H. influenzae and against most enterobacteria, but it is susceptible to common enterobacterial β-lactamases. Pr. vulgaris and Providencia, Acinetobacter and Serratia spp. are resistant. B. fragilis and clostridia are resistant but other anaerobes are commonly susceptible.

Pharmacokinetics

Oral absorption: c. 90%
Cmax 250 mg oral: c. 6–7 mg/L after 50 min
Plasma half-life: 0.5–1 h
Volume of distribution: 0.37 L
Plasma protein binding: 25%
Absorption
Food intake increases the time taken to reach peak plasma levels and reduces the peak by 25–50%. The actual amount absorbed is unaffected. In children receiving 15 mg/kg per day (maximum daily dose 1 g) the mean peak serum level was 16.8 mg/L at 0.5–1 h. There is no accumulation of the drug during repeated administration.
Distribution
In patients receiving 500 mg every 8 h for 10 days, concentrations were 0–1.7 (mean 0.5) mg/L in mucoid sputum and 0–2.8 (mean 1.0) mg/L in purulent sputum. In children with chronic serous otitis media receiving 15 mg/kg per day, the mean peak concentration in middle ear secretion was 3.8 mg/L within 30 min of the dose when the mean simultaneous serum concentration was 12.8 mg/L.
Metabolism and excretion No metabolites have been identified, but the drug probably chemically degrades in serum. About half of the dose is recovered from the urine in the first 6 h and 70% in 24 h. Probenecid prolongs the plasma levels but in renal insufficiency the plasma half-life is only moderately increased. In patients with creatinine clearance values of 5–15 mL/min the mean plasma elimination half-life rose to 2.3 h and the 24 h urinary excretion fell to less than 10%. In patients requiring intermittent hemodialysis and receiving 500 mg every 8 h for 10 days, the half-life rose to 2.9 h. Dialysis removed 34% of the dose

Clinical Use

Uses are similar to those of other group 2 cephalosporins. It is among the few suitable for use in respiratory infections because of its activity against H. influenzae.

Side effects

Apart from mild gastrointestinal disturbance, the drug is well tolerated. Transiently increased transaminase levels and symptomatic vaginal candidosis have been noted. Clusters of a serum sickness-like illness have been described in children.

Cefaclor Preparation Products And Raw materials

Raw materials

Preparation Products


Cefaclor Suppliers

Global( 161)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3217 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22049 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32651 55
Hubei Jusheng Technology Co.,Ltd.
86-155-27864001
peter@hubeijusheng.com CHINA 18004 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 19990 58
Wuhan ze shan cheng Biomedical Technology Co., Ltd. 027-51477051 17786425391
027-51477052 17786425391@163.com China 242 58
future industrial shanghai co., ltd 400-0066-400;021-60496031
021-55660885 sales@jonln.com China 2042 65
LGM Pharma 1-(800)-881-8210
615-250-9817 inquiries@lgmpharma.com United States 1954 70
Hangzhou Yuhao Chemical Technology Co., Ltd 0571-82693216
+86-571-82880190 info@yuhaochemical.com China 9430 52

View Lastest Price from Cefaclor manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-17 Cefaclor
53994-73-3
US $1.00 / KG 1G 98% 100KG career henan chemical co

Cefaclor Spectrum


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