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CROSCARMELLOSE SODIUM

CAS No.
74811-65-7
Chemical Name:
CROSCARMELLOSE SODIUM
Synonyms
Sodiumcroscarmellose;PRIMELLOSE(R);Unii-m28ol1hh48;Crosscarmelosesodium;Croscarmelose Sodium;CROSCARMELLOSE SODIUM;MODIFIED CELLULOSE GUM;Croscarmellose natrium;Ropinirole Impurity 11-d4;CroscarMellose sodiuM Ph. Eur.
CBNumber:
CB9418013
Molecular Formula:
Null
Molecular Weight:
0
MDL Number:
MFCD00217760
MOL File:
Mol file
Last updated:2023-11-21 17:01:47

CROSCARMELLOSE SODIUM Properties

Melting point >205oC (dec.)
Density Bulk density (g/cc) 0.48
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility Practically insoluble in acetone, in anhydrous ethanol and in toluene.
form Solid
color White to Off-White
Odor at 100.00?%. odorless
EWG's Food Scores 1
FDA UNII M28OL1HH48
EPA Substance Registry System Croscarmellose sodium (74811-65-7)

CROSCARMELLOSE SODIUM price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC C816500 CroscarmelloseSodium 74811-65-7 1g $55 2021-12-16 Buy
Product number Packaging Price Buy
C816500 1g $55 Buy

CROSCARMELLOSE SODIUM Chemical Properties,Uses,Production

Chemical Properties

pH 5.0-7.0 tablet disintegrant.

Chemical Properties

Croscarmellose sodium occurs as an odorless, white or grayishwhite powder.

Uses

Pharmaceutic aid (tablet disintegrant).

Uses

Used as Disintegrant in Capsules, Tablet and Granule Formulations.

Uses

Packaged under nitrogen

Uses

antimicrobial

Uses

Croscarmellose Sodiumis a super disintegrant used in pharmaceuticals in the synthesis of tablets for oral administration.

Production Methods

Alkali cellulose is prepared by steeping cellulose, obtained from wood pulp or cotton fibers, in sodium hydroxide solution. The alkali cellulose is then reacted with sodium monochloroacetate to obtain carboxymethylcellulose sodium. After the substitution reaction is completed and all of the sodium hydroxide has been used, the excess sodium monochloroacetate slowly hydrolyzes to glycolic acid. The glycolic acid changes a few of the sodium carboxymethyl groups to the free acid and catalyzes the formation ofcrosslinkstoproducecroscarmellosesodium.Thecroscarmellose sodium is then extracted with aqueous alcohol and any remaining sodium chloride or sodium glycolate is removed. After purification, croscarmellose sodium of purity greater than 99.5% is obtained. The croscarmellose sodium may be milled to break the polymer fibers into shorter lengths and hence improve its flow properties.

brand name

Ac-Di-Sol (FMC); CLD 2 (Buckeye).

Pharmaceutical Applications

Croscarmellose sodium is used in oral pharmaceutical formulations as a disintegrant for capsules,tablets, and granules.
In tablet formulations, croscarmellose sodium may be used in bothdirect-compressionandwet-granulationprocesses.Whenused in wet granulations, the croscarmellose sodium should be added in both the wet and dry stages of the process (intra- and extragranularly) so that the wicking and swelling ability of the disintegrant is best utilized. Croscarmellose sodium at concentrations up to 5% w/w may be used as a tablet disintegrant, although normally 2% w/w is used in tablets prepared by direct compression and 3% w/w in tablets prepared by a wet-granulation process.

Safety

Croscarmellose sodium is mainly used as a disintegrant in oral pharmaceutical formulations and is generally regarded as an essentially nontoxic and nonirritant material. However, oral consumption of large amounts of croscarmellose sodium may have a laxative effect, although the quantities used in solid dosage formulations are unlikely to cause such problems.
In the UK, croscarmellose sodium is accepted for use in dietary supplements.
The WHO has not specified an acceptable daily intake for the related substance carboxymethylcellulose sodium, used as a food additive, since the levels necessary to achieve a desired effect were not considered sufficient to be a hazard to health.

storage

Croscarmellose sodium is a stable though hygroscopic material.
A model tablet formulation prepared by direct compression, withcroscarmellosesodiumasadisintegrant,showednosignificant differenceindrugdissolutionafterstorageat30°Cfor14months.
Croscarmellose sodium should be stored in a well-closed container in a cool, dry place.

Incompatibilities

The efficacy of disintegrants, such as croscarmellose sodium, may be slightly reduced in tablet formulations prepared by either the wet-granulation or direct-compression process that contain hygroscopic excipients such as sorbitol.
Croscarmellose sodium is not compatible with strong acids or with soluble salts of iron and some other metals such as aluminum, mercury, and zinc.

Regulatory Status

Included in the FDA Inactive Ingredients Database (oral capsules, granules, sublingual tablets, and tablets). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

CROSCARMELLOSE SODIUM Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 198)Suppliers
Supplier Tel Email Country ProdList Advantage
Jiangxi Alpha Hi-tech Pharmaceutical Co., Ltd
510-85010237 overseamarketing@alphahi-tech.com CHINA 41 58
Hebei Mojin Biotechnology Co., Ltd
+86-13288715578 +86-13231137666 sales@hbmojin.com China 12409 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177 peter@yan-xi.com China 5960 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21703 55
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714 fandachem@gmail.com China 9359 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +86-18949832763 info@tnjchem.com China 2989 55
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29919 58
Hebei Guanlang Biotechnology Co., Ltd.
+86-19930503282 alice@crovellbio.com China 8823 58
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Shanghai Longyu Biotechnology Co., Ltd.
+8615821988213 info@longyupharma.com China 2530 58

View Lastest Price from CROSCARMELLOSE SODIUM manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
CROSCARMELLOSE SODIUM pictures 2023-11-30 CROSCARMELLOSE SODIUM
74811-65-7
US $10.00 / KG 1KG 99%HPLC,USP Standard 5000KGs ZhenYiBio Technology Inc
CROSCARMELLOSE SODIUM pictures 2023-11-21 CROSCARMELLOSE SODIUM
74811-65-7
US $30.00-10.00 / kg 1kg 0.99 20 tons Hebei Yanxi Chemical Co., Ltd.
CROSCARMELLOSE SODIUM pictures 2023-09-06 CROSCARMELLOSE SODIUM
74811-65-7
US $0.00-0.00 / KG 1KG 99% 500000kg Hebei Guanlang Biotechnology Co., Ltd.
CROSCARMELLOSE SODIUM MODIFIED CELLULOSE GUM PRIMELLOSE(R) Crosscarmelosesodium Croscarmellose natrium Cross-linked carboxymethylcellulose sodium Unii-m28ol1hh48 CroscarMellose sodiuM Ph. Eur. Sodiumcroscarmellose 1,4-Pentanediamine,N4-(6-methoxy-13-quinolinyl)- Ropinirole Impurity 11-d4 Croscarmelose Sodium 74811-65-7 4811-65-7