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PF-06700841 tosylate

PF-06700841 tosylate structure

CAS No.: 1883299-62-4

Chemical Name:: PF-06700841 tosylate

Synonyms: PF841;PF 841;PF-841;CS-2861;PF6700841;PF 6700841;PF-6700841;PF-06700841 tosylate;Brepocitinib (PF-06700841);inhibit,Janus kinase,PF06700841,JAK,Brepocitinib,Inhibitor,PF 06700841

CBNumber:: CB94674167

Molecular Formula:: C18H21F2N7O

Molecular Weight:: 389.4

MDL Number:: MFCD31813694

MOL File:: 1883299-62-4.mol

Last updated:2024-05-28 11:51:27

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PF-06700841 tosylate Properties

Boiling point	637.1±65.0 °C(Predicted)
Density	1.63±0.1 g/cm3(Predicted)
storage temp.	room temp
solubility	DMSO: 78 mg/mL (200.31 mM);Ethanol: 78 mg/mL (200.31 mM)
form	powder
pka	7.28±0.10(Predicted)
color	white to beige
Water Solubility	Water: Insoluble
FDA UNII	3X8387Q25N

PF-06700841 tosylate price More Price(7)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PZ0345	PF-06700841 tosylate salt ≥98% (HPLC)	1883299-62-4	5mg	$114	2024-03-01	Buy
Biorbyt Ltd	orb573132	PF-06700841 tosylate >98%	1883299-62-4	100mg	$1283.5	2021-12-16	Buy
Biorbyt Ltd	orb573132	PF-06700841 tosylate >98%	1883299-62-4	250mg	$2245.7	2021-12-16	Buy
Biorbyt Ltd	orb573132	PF-06700841 tosylate >98%	1883299-62-4	1g	$4766.8	2021-12-16	Buy
DC Chemicals	DC12489	PF-06700841freebase >98%	1883299-62-4	1g	$3200	2021-12-16	Buy

Product number	Packaging	Price	Buy
PZ0345	5mg	$114	Buy
orb573132	100mg	$1283.5	Buy
orb573132	250mg	$2245.7	Buy
orb573132	1g	$4766.8	Buy
DC12489	1g	$3200	Buy

PF-06700841 tosylate Chemical Properties,Uses,Production

Chemical Properties

The p-toluenesulfonic acid salt of brepocitinib exhibits good aqueous solubility (4.84 mg/mL at pH 7.64; >7 mg/mL in simulated gastric fluids). This compound also displayed high passive membrane permeability (mean PAPP = 18.8 × 10?6 cm/s as determined using Ralph Russ canine kidney cells (RRCK)).

Characteristics

Class: non-receptor tyrosine kinase
Treatment: immunological disorders
Other name: PF-06700841; Brepocitinib
Elimination half-life = 3.8–7.5 h
Protein binding = 39%

Uses

PF-06700841 tosylate salt has been used as an inhibitor of Janus kinase1 (JAK1) to study its therapeutic effect on the adjuvant induced arthritis (AIA) rat model. It has also been used as an inhibitor of interferon-α/β receptor alpha chain (IFNAR1) signaling adaptor tyrosine kinase (2TYK2) in mice.

Biochem/physiol Actions

PF-06700841 prevents IL-23 (interleukin 23) signaling through TYK2 (Tyrosine-protein kinase 2)/JAK1 (Janus kinase 1) inhibition.

Pharmacokinetics

The high oral bioavailability of brepocitinib obtained from rats (83%) is consistent with its high passive permeability and good solubility. The elimination half-life of brepocitinib ranged from 3.8 to 7.5 h after a single oral dose and from 4.9 to 10.7 h after multiple-dose administration. It was eliminated from the body by CYP450-mediated hepatic metabolism (84%) (mainly via CYP3A4) and renal clearance (16%). Oxidation of the N-methyl pyrazole (2) is the major metabolic pathway, followed by N-demethylation (3) and N-dealkylation with loss of pyrazole (4).
PF-06700841 tosylate

PF-06700841 tosylate Preparation Products And Raw materials

Raw materials

Preparation Products

PF-06700841 tosylate Suppliers

Global( 68)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	7154	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5738	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
NINGBOBENKANGJS PHARMTECHCO., LTD	+8615990591583 15990591583		CHINA	2029	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Jinan Carbotang Biotech Co.,Ltd.	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
Career Henan Chemica Co	58
NINGBOBENKANGJS PHARMTECHCO., LTD	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
LEAP CHEM CO., LTD.	58
Nantong HI-FUTURE Biology Co., Ltd.	58

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PF-06700841 tosylate ((S)-2,2-difluorocyclopropyl)(3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone PF 6700841 PF-06700841; PF 06700841; PF06700841; PF-6700841; PF 6700841; PF6700841; PF-06700841 TOSYLATE SALT PF6700841 PF-6700841 CS-2861 ((S)-2,2-difluorocyclopropyl)((1R,5S)-3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone Methanone, [(1S)-2,2-difluorocyclopropyl][3-[2-[(1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl]-3,8-diazabicyclo[3.2.1]oct-8-yl]- Brepocitinib (PF-06700841) inhibit,Janus kinase,PF06700841,JAK,Brepocitinib,Inhibitor,PF 06700841 PF 841 PF841 PF-841 1883299-62-4 C18H21F2N7O api APIS